Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Justin M Drake"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Cellular retinoic acid binding protein 1 (CRABP1) mediates rapid, non-canonical activity of retinoic acid (RA) by forming signalosomes via protein-protein interactions. Two signalosomes have been identified previously: CRABP1-MAPK
Externí odkaz:
https://doaj.org/article/c24d6167825643d29af7be4b52a65e45
ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems
Autor:
Hannah E. Bergom, Ashraf Shabaneh, Abderrahman Day, Atef Ali, Ella Boytim, Sydney Tape, John R. Lozada, Xiaolei Shi, Carlos Perez Kerkvliet, Sean McSweeney, Samuel P. Pitzen, Megan Ludwig, Emmanuel S. Antonarakis, Justin M. Drake, Scott M. Dehm, Charles J. Ryan, Jinhua Wang, Justin Hwang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and prior exposure to therapy. Here, we developed the Algorithm for Linking Activity Networks (ALAN)
Externí odkaz:
https://doaj.org/article/beba2e91e3c64bb1936e18c40ebe3097
Autor:
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-6 (2022)
Abstract B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation i
Externí odkaz:
https://doaj.org/article/4430f98cbc41482e987673e7579881aa
Autor:
Ralph E. White, Maxwell Bannister, Abderrahman Day, Hannah E. Bergom, Victor M. Tan, Justin Hwang, Hai Dang Nguyen, Justin M. Drake
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Prostate cancer (PCa) remains the most diagnosed non-skin cancer amongst the American male population. Treatment for localized prostate cancer consists of androgen deprivation therapies (ADTs), which typically inhibit androgen production and the andr
Externí odkaz:
https://doaj.org/article/2c4c23f36cda4974bca482b9155658b3
Autor:
Song Yi Bae, Hannah E. Bergom, Abderrahman Day, Joseph T. Greene, Zoi E. Sychev, Gabrianne Larson, Eva Corey, Stephen R. Plymate, Tanya S. Freedman, Justin H. Hwang, Justin M. Drake
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer. NEPC is characterized by the loss of androgen receptor (AR) signaling and transdifferentiation toward small-cell neuroendocrine (SCN) phenotypes, which results i
Externí odkaz:
https://doaj.org/article/3e48ddb167a545a593cf9fd00b156061
Autor:
Justin H Hwang, Rand Arafeh, Ji-Heui Seo, Sylvan C Baca, Megan Ludwig, Taylor E Arnoff, Lydia Sawyer, Camden Richter, Sydney Tape, Hannah E Bergom, Sean McSweeney, Jonathan P Rennhack, Sarah A Klingenberg, Alexander TM Cheung, Jason Kwon, Jonathan So, Steven Kregel, Eliezer M Van Allen, Justin M Drake, Matthew L Freedman, William C Hahn
Publikováno v:
eLife, Vol 11 (2022)
Metastatic castration-resistant prostate cancers (mCRPCs) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ARTs). Our previous work identified CREB5 as an upregula
Externí odkaz:
https://doaj.org/article/7cd78141b68a418da9a9913b29b5f5c7
Autor:
Hui-wen Lue, Daniel S. Derrick, Soumya Rao, Ahna Van Gaest, Larry Cheng, Jennifer Podolak, Samantha Lawson, Changhui Xue, Devin Garg, Ralph White, III, Christopher W. Ryan, Justin M. Drake, Anna Ritz, Laura M. Heiser, George V. Thomas
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100267- (2021)
Summary: The lack of effective treatment options for advanced non-clear cell renal cell carcinoma (NCCRCC) is a critical unmet clinical need. Applying a high-throughput drug screen to multiple human kidney cancer cells, we identify the combination of
Externí odkaz:
https://doaj.org/article/81d895defe654fc78a2802b6f737cb09
Autor:
Bryce M Paschal, David Wotton, Aakrosh Ratan, Tarek Abbas, Justin M Drake, Nicki Abianeh, Sachi B Tengse, Song Yi Bae, Natalia M Dworak, Krzysztof Wierbilowicz, Chunsong Yang
Extendend analysis of PARP7 expression in prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03590069a40be835a1343ac1296947ea
https://doi.org/10.1158/2767-9764.22644768
https://doi.org/10.1158/2767-9764.22644768
Autor:
Bryce M Paschal, David Wotton, Aakrosh Ratan, Tarek Abbas, Justin M Drake, Nicki Abianeh, Sachi B Tengse, Song Yi Bae, Natalia M Dworak, Krzysztof Wierbilowicz, Chunsong Yang
FACS analysis of NCI-H660 cells for detection of necrosis and apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00cfa0e64334d0f2508ac53d2142735
https://doi.org/10.1158/2767-9764.22644771.v1
https://doi.org/10.1158/2767-9764.22644771.v1
Autor:
Bryce M. Paschal, David Wotton, Aakrosh Ratan, Tarek Abbas, Justin M. Drake, Nicki Abianeh, Sachi B. Tengse, Song Yi Bae, Natalia M. Dworak, Krzysztof Wierbiłowicz, Chunsong Yang
Supplementary Table 1: RBN2397 growth effects in prostate cencer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854b057049a9ae1504baf7a3d7d66e8c
https://doi.org/10.1158/2767-9764.22644765.v1
https://doi.org/10.1158/2767-9764.22644765.v1