Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Justin M, Waldern"'
Autor:
Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Publikováno v:
eLife, Vol 11 (2022)
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Externí odkaz:
https://doaj.org/article/7e9b5b2f330645718e814d97ac9b25a0
Autor:
Justin M. Waldern, Dorie Smith, Carol Lyn Piazza, E. Jake Bailey, Nicholas J. Schiraldi, Reza Nemati, Dan Fabris, Marlene Belfort, Olga Novikova
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing. These molec
Externí odkaz:
https://doaj.org/article/3060b5bd7d624edc9c8156bc8e2e2450
Autor:
Ian C Redmon, Matthew Ardizzone, Hilal Hekimoğlu, Breanne M Hatfield, Justin M Waldern, Abhishek Dey, Stephanie A Montgomery, Alain Laederach, Silvia B V Ramos
Publikováno v:
Nucleic acids research. 50(7)
Zinc finger protein 36 like 2 (ZFP36L2) is an RNA-binding protein that destabilizes transcripts containing adenine-uridine rich elements (AREs). The overlap between ZFP36L2 targets in different tissues is minimal, suggesting that ZFP36L2-targeting is
Autor:
Jayashree, Kumar, Lela, Lackey, Justin M, Waldern, Abhishek, Dey, Anthony M, Mustoe, Kevin M, Weeks, David H, Mathews, Alain, Laederach
Publikováno v:
eLife. 11
Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing
Publikováno v:
Human genetics. 141(10)
Disease-associated variants (DAVs) are commonly considered either through a genomic lens that describes variant function at the DNA level, or at the protein function level if the variant is translated. Although the genomic and proteomic effects of va
Autor:
Marlene Belfort, Dorie Smith, Reza Nemati, Justin M. Waldern, E. Jake Bailey, Carol Lyn Piazza, Dan Fabris, Olga Novikova, Nicholas J. Schiraldi
Publikováno v:
Mobile DNA
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing. These molecules can
Publikováno v:
Molecular Biology and Evolution
Group II (gII) introns are mobile retroelements that can spread to new DNA sites through retrotransposition, which can be influenced by a variety of host factors. To determine if these host factors bear any relationship to the genomic location of gII