Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

Autor: Xuan Jiang, John S. Hawkins, Jerry Lee, Carlos O. Lizama, Frank L. Bos, Joan P. Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna, Ann C. Zovein, Akiko Hata

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4

Externí odkaz: https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4

Primary Biliary Cholangitis: A Brief Overview

Autor: Justin Louie, Sirisha Grandhe, Karen Matsukuma, Christopher L. Bowlus

Publikováno v: Clinical liver disease, vol 15, iss 3

http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-3-reading-louie a video presentation of this article.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afcb23a4a41556947b650328fd9f56d
https://doi.org/10.1002/cld.867

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

Autor: Ann C. Zovein, John S. Hawkins, Prajakta Ghatpande, Carlos Lizama, Frank L. Bos, Jerry Lee, Yongbo Peng, Giorgio Lagna, Joan P. Zape, Akiko Hata, Xuan Jiang, Justin Louie

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Jiang, X; Hawkins, JS; Lee, J; Lizama, CO; Bos, FL; Zape, JP; et al.(2017). Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-00137-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/22b5c9x9

Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through unknown mechanisms. Here we report that vascular endothelium-specific deletion of mouse Drosha (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0823d90e39dbfe036c6f4b0292515534
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4

Tissue-specific 3 prime-end adenylation of miR-125b mediates cell survival

Autor: Akiko Hata, Jean-Charles Neel, Justin Louie, Matthew T. Blahna, Ge Yu, Prajakta Ghatpande, Giorgio Lagna

Next-generation sequencing has uncovered microRNAs (miRNAs) that undergo sequence modifications, known as isomiRs. Their physiological significance, however, remains uncertain, partly because they generally comprise a small fraction of total miRNAs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ba229ad883f6e704eff36aac7482e

Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress

Autor: Roberto Sessa, Akiko Hata, Xuan Jiang, Giorgio Lagna, Brandi N. Davis-Dusenbery, Jonathan Chang, Justin Louie, Nisha Marathe, Risa Kashima, Wei Gu

Publikováno v: The EMBO Journal. 32:3192-3205

It is widely accepted that different forms of stress activate a common target, p53, yet different outcomes are triggered in a stress-specific manner. For example, activation of p53 by genotoxic agents, such as camptothecin (CPT), triggers apoptosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::741f1e00d26ca737e220cabfc1f04544
https://doi.org/10.1038/emboj.2013.242