Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Justin Lecher"'
Autor:
Vineet Panwalkar, Marianne Schulte, Justin Lecher, Matthias Stoldt, Dieter Willbold, Andrew J Dingley
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 605-612 (2016)
The third WW domain (WW3*) of human Nedd4-1 (Neuronal precursor cell expressed developmentally down-regulated gene 4-1) interacts with the poly-proline (PY) motifs of the human epithelial Na+ channel (hENaC) subunits at micromolar affinity. This data
Externí odkaz:
https://doaj.org/article/c3df611656964ba1bce8208be21118be
The Nedd4–1 WW Domain Recognizes the PY Motif Peptide through Coupled Folding and Binding Equilibria
Autor:
Michael Schmitz, Matthias Stoldt, Marianne Schulte, Vineet Panwalkar, Karima Medini, Margaret A. Brimble, Philipp Neudecker, Dieter Willbold, Justin Lecher, Andrew J. Dingley
Publikováno v:
Biochemistry. 55:659-674
The four WW domains of human Nedd4-1 (neuronal precursor cell expressed developmentally downregulated gene 4-1) interact with the PPxY (PY) motifs of the human epithelial Na(+) channel (hENaC) subunits, with the third WW domain (WW3*) showing the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d94cc91ddae2f97a944a022d26f9b7
https://doi.org/10.1021/acs.biochem.5b01028
https://doi.org/10.1021/acs.biochem.5b01028
Autor:
Dieter Willbold, Sven Schünke, Ulrich Benjamin Kaupp, Claudia Börger, Friederike Winkhaus, Justin Lecher, Matthias Stoldt
Publikováno v:
Journal of Biomolecular NMR
Hyperpolarization activated and cyclic nucleotide-gated (HCN) ion channels as well as cyclic nucleotide-gated (CNG) ion channels are essential for the regulation of cardiac cells, neuronal excitability, and signaling in sensory cells. Both classes ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a19a0cf9666fba6a6e6d9dda422b33
https://doi.org/10.1007/s12104-014-9583-x
https://doi.org/10.1007/s12104-014-9583-x
Autor:
Matthias Stoldt, Justin Lecher, Şerife Akgül, Wolfgang Hoyer, Hamed Shaykhalishahi, Aziz Gauhar, Dieter Willbold, Ewa A. Mirecka
Publikováno v:
Angewandte Chemie. 126:4311-4314
Fehlfaltung, Aggregation und Amyloidfibrillenbil- dung des Proteins a-Synuclein (a-syn) sind an der Pathogenese der Parkinson-Krankheit und weiterer Synucleinopathien be- teiligt. Die Entwicklung der Amyloid-Toxizitt steht in Zu- sammenhang mit der B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a73934b1548483bc61810cf731858b06
https://doi.org/10.1002/ange.201309001
https://doi.org/10.1002/ange.201309001
Autor:
Şerife Akgül, Justin Lecher, Hamed Shaykhalishahi, Wolfgang Hoyer, Matthias Stoldt, Ewa A. Mirecka, Dieter Willbold, Aziz Gauhar
Publikováno v:
Angewandte Chemie International Edition. 53:4227-4230
The misfolding and aggregation of the protein α-synuclein (α-syn), which results in the formation of amyloid fibrils, is involved in the pathogenesis of Parkinson's disease and other synucleinopathies. The emergence of amyloid toxicity is associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374a4e8d8a494cd4167dc04223d88b18
https://doi.org/10.1002/anie.201309001
https://doi.org/10.1002/anie.201309001
Autor:
Matthias Stoldt, Christian Schwarz, Lutz Schmitt, Justin Lecher, Dieter Willbold, Sander H. J. Smits
Publikováno v:
Structure. 20(10):1778-1787
Summary Type 1 secretion systems (T1SS) catalyze the one step protein transport across the membranes of Gram-negative bacteria and are composed of an outer membrane protein, a membrane fusion protein and an ABC transporter. The ABC transporter consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f5c17f15805bb0806eca6c5eebf6dd
Autor:
Hans-Henning Ludwig, Matthias Stoldt, Hans-Ulrich Demuth, Martin Kleinschmidt, Justin Lecher, Dieter Willbold, Susanne Aileen Funke, Rudolf Hartmann, Na Sun, Lothar Gremer
Publikováno v:
Journal of Peptide Science. 18:691-695
The aggregation of the Aβ plays a fundamental role in the pathology of AD. Recently, N-terminally modified Aβ species, pE-Aβ, have been described as major constituents of Aβ deposits in the brains of AD patients. pE-Aβ has an increased aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70399ccbfd9e1d593ab92a1738e32b35
https://doi.org/10.1002/psc.2456
https://doi.org/10.1002/psc.2456
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cyclic nucleotide-sensitive ion channels, known as HCN and CNG channels, are activated by binding of ligands to a domain (CNBD) located on the cytoplasmic side of the channel. The underlying mechanisms are not well understood. To elucidate the gating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2628055cb63a2c1ff5e0a57ea0042b09
https://doi.org/10.1073/pnas.1015890108
https://doi.org/10.1073/pnas.1015890108
Publikováno v:
Biomolecular NMR Assignments. 4:147-150
Cyclic nucleotide-sensitive ion channels, known as HCN and CNG channels play crucial roles in neuronal excitability and signal transduction of sensory cells. These channels are activated by binding of cyclic nucleotides to their intracellular cyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9eabbabe18a054f75dcaea2d165a96f
https://doi.org/10.1007/s12104-010-9231-z
https://doi.org/10.1007/s12104-010-9231-z
Autor:
Marco Pittelkow, Lutz Schmitt, Justin Lecher, Sander H. J. Smits, Tobias Bönig, Erhard Bremer, Silke Zobel, Jan Bursy
Publikováno v:
Journal of Molecular Biology. 389:58-73
Substrate-binding proteins or extracellular solute receptors (ESRs) are components of both ABC (ATP binding cassette) and TRAP-T (tripartite ATP-independent periplasmic transporter). The TRAP-T system UehABC from Silicibacter pomeroyi DSS-3 imports t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90418e5aaafe4f6c1cf598ce569bf955
https://doi.org/10.1016/j.jmb.2009.03.077
https://doi.org/10.1016/j.jmb.2009.03.077