Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Justin LaClair"'
Autor:
Joseph M. Chan, Samir Zaidi, Jillian R. Love, Jimmy L. Zhao, Manu Setty, Kristine M. Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J. Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W. Goodrich, Wouter R. Karthaus, Dana Pe’er, Charles L. Sawyers
Publikováno v:
Science
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc0219b760014ba836a35febf50293
https://doi.org/10.1126/science.abn0478
https://doi.org/10.1126/science.abn0478
Autor:
Elizabeth V. Wasmuth, Arnaud Vanden Broeck, Justin LaClair, Kayla E. Lawrence, Elizabeth A. Hoover, Kyrie Pappas, Biran Wang, Katia Manova‐Todorova, Susan T. Weintraub, Sebastian Klinge, Charles L. Sawyers
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262321f24f250c259161c85f0b12045e
https://doi.org/10.1096/fasebj.2022.36.s1.r2062
https://doi.org/10.1096/fasebj.2022.36.s1.r2062
Publikováno v:
Cancer Research. 82:391-391
Cancers harboring bi-allelic loss of the breast cancer genes (BRCA1 and BRCA2) are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPi), which are clinically approved in breast, ovarian, and more recently prostate cancer. Genetic alteration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a9e7dae98a051d58faae2b44fa1052d
https://doi.org/10.1158/1538-7445.am2022-391
https://doi.org/10.1158/1538-7445.am2022-391
Autor:
Joseph M. Chan, Wouter R. Karthaus, Manu Setty, Jillian R. Love, Samir Zaidi, Jimmy Zhao, Zi-ning Choo, Sitara Persad, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Ignas Masilionis, Linas Mazutis, Ronan Chaligne, Dana Pe'er, Charles Sawyers
Publikováno v:
Cancer Research. 82:1594-1594
The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7224bb3dbd5cd0d443d50d092acedc78
https://doi.org/10.1158/1538-7445.am2022-1594
https://doi.org/10.1158/1538-7445.am2022-1594