Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Justin L. Sonnenburg"'
Autor:
Varun B. Dwaraka, Lucia Aronica, Natalia Carreras-Gallo, Jennifer L. Robinson, Tayler Hennings, Matthew M. Carter, Michael J. Corley, Aaron Lin, Logan Turner, Ryan Smith, Tavis L. Mendez, Hannah Went, Emily R. Ebel, Erica D. Sonnenburg, Justin L. Sonnenburg, Christopher D. Gardner
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Geroscience focuses on interventions to mitigate molecular changes associated with aging. Lifestyle modifications, medications, and social factors influence the aging process, yet the complex molecular mechanisms require an in-dep
Externí odkaz:
https://doaj.org/article/869a3e24e5c04b8ab44dadf995536283
Autor:
Carlos Geert Pieter Voogdt, Surya Tripathi, Stefan Oliver Bassler, Saria A. McKeithen-Mead, Emma R. Guiberson, Alexandra Koumoutsi, Afonso Martins Bravo, Cullen Buie, Michael Zimmermann, Justin L. Sonnenburg, Athanasios Typas, Adam M. Deutschbauer, Anthony L. Shiver, Kerwyn Casey Huang
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113519- (2024)
Summary: The critical role of the intestinal microbiota in human health and disease is well recognized. Nevertheless, there are still large gaps in our understanding of the functions and mechanisms encoded in the genomes of most members of the gut mi
Externí odkaz:
https://doaj.org/article/f55492c84db847c78fb9dfafefb55708
Autor:
Surya Tripathi, Carlos Geert Pieter Voogdt, Stefan Oliver Bassler, Mary Anderson, Po-Hsun Huang, Nazgul Sakenova, Tümay Capraz, Sunit Jain, Alexandra Koumoutsi, Afonso Martins Bravo, Valentine Trotter, Michael Zimmerman, Justin L. Sonnenburg, Cullen Buie, Athanasios Typas, Adam M. Deutschbauer, Anthony L. Shiver, Kerwyn Casey Huang
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113517- (2024)
Summary: Randomly barcoded transposon mutant libraries are powerful tools for studying gene function and organization, assessing gene essentiality and pathways, discovering potential therapeutic targets, and understanding the physiology of gut bacter
Externí odkaz:
https://doaj.org/article/023823f8c8824e889806312e660b82aa
Autor:
Hannah C. Wastyk, Dalia Perelman, Madeline Topf, Gabriela K. Fragiadakis, Jennifer L. Robinson, Justin L. Sonnenburg, Christopher D. Gardner, Erica D. Sonnenburg
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTAn individual’s immune and metabolic status is coupled to their microbiome. Probiotics offer a promising, safe route to influence host health, possibly via the microbiome. Here, we report an 18-week, randomized prospective study that explor
Externí odkaz:
https://doaj.org/article/4b17c103a37b42a5a01b019089c3f710
Autor:
Rebecca H. Gellman, Matthew R. Olm, Nicolas Terrapon, Fatima Enam, Steven K. Higginbottom, Justin L. Sonnenburg, Erica D. Sonnenburg
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113233- (2023)
Summary: Industrialization has transformed the gut microbiota, reducing the prevalence of Prevotella relative to Bacteroides. Here, we isolate Bacteroides and Prevotella strains from the microbiota of Hadza hunter-gatherers in Tanzania, a population
Externí odkaz:
https://doaj.org/article/536b19149a27436d8af28d8b7f12a312
Autor:
Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren, Steven K. Higginbottom, John B. Jarman, Curt R. Fischer, Justin Mak, Beverly Wong, Tina M. Cowan, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate,
Externí odkaz:
https://doaj.org/article/14334ccffc5848da904c149209a88138
Autor:
George B. Saffouri, Robin R. Shields-Cutler, Jun Chen, Yi Yang, Heather R. Lekatz, Vanessa L. Hale, Janice M. Cho, Eric J. Battaglioli, Yogesh Bhattarai, Kevin J. Thompson, Krishna K. Kalari, Gaurav Behera, Jonathan C. Berry, Stephanie A. Peters, Robin Patel, Audrey N. Schuetz, Jeremiah J. Faith, Michael Camilleri, Justin L. Sonnenburg, Gianrico Farrugia, Jonathan R. Swann, Madhusudan Grover, Dan Knights, Purna C. Kashyap
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Small intestinal bacterial overgrowth (SIBO) has been associated with functional gastrointestinal disorders. Here, the authors show that SIBO may be a result of dietary preferences, and patient symptoms correlate with changes in small intestinal micr
Externí odkaz:
https://doaj.org/article/32a844355ed94b92862ae083fcfb70df
Autor:
Yogesh Bhattarai, Si Jie, David R. Linden, Sayak Ghatak, Ruben A.T. Mars, Brianna B. Williams, Meng Pu, Justin L. Sonnenburg, Michael A. Fischbach, Gianrico Farrugia, Lei Sha, Purna C. Kashyap
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101798- (2020)
Summary: Recent studies emphasize the role of microbial metabolites in regulating gastrointestinal (GI) physiology through activation of host receptors, highlighting the potential for inter-kingdom signaling in treating GI disorders. In this study, w
Externí odkaz:
https://doaj.org/article/b5bee85c22b34b76b33cddfd843fc131
Autor:
Carlos G. Gonzalez, Hannah C. Wastyk, Madeline Topf, Christopher D. Gardner, Justin L. Sonnenburg, Joshua E. Elias
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Stool-based proteomics is capable of significantly augmenting our understanding of host-gut microbe interactions. However, compared to competing technologies, such as metagenomics and 16S rRNA sequencing, it is underutilized due to its low t
Externí odkaz:
https://doaj.org/article/7ca76f12b78f491aab440c6f1d3f68ee
Autor:
Megan Garland, Andrew J. Hryckowian, Martina Tholen, Kristina Oresic Bender, William W. Van Treuren, Sebastian Loscher, Justin L. Sonnenburg, Matthew Bogyo
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 1, Pp 100005- (2020)
Summary: Clostridium difficile infection (CDI) is an enteric bacterial disease that is increasing in prevalence worldwide. C. difficile capitalizes on gut inflammation and microbiome dysbiosis to establish infection, with symptoms ranging from watery
Externí odkaz:
https://doaj.org/article/3a28be6e9db14e62b54e3596a530dc64