Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Justin L McCarville"'
Autor:
Justin L McCarville, Yotam Nisemblat, Heather J Galipeau, Jennifer Jury, Rinat Tabakman, Ad Cohen, Esmira Naftali, Bela Neiman, Efrat Halbfinger, Joseph A Murray, Arivarasu N Anbazhagan, Pradeep K Dudeja, Alexander Varvak, Jean-Christophe Leroux, Elena F Verdu
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e109972 (2014)
Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-
Externí odkaz:
https://doaj.org/article/7087f82fe61d4343ab2aa2478ca871df
Spaceflight influences both mucosal and peripheral cytokine production in PTN-Tg and wild type mice.
Autor:
Justin L McCarville, Sandra T Clarke, Padmaja Shastri, Yi Liu, Martin Kalmokoff, Stephen P J Brooks, Julia M Green-Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68961 (2013)
Spaceflight is associated with several health issues including diminished immune efficiency. Effects of long-term spaceflight on selected immune parameters of wild type (Wt) and transgenic mice over-expressing pleiotrophin under the human bone-specif
Externí odkaz:
https://doaj.org/article/0d6afd5571d447a999e9a1ff67b5c508
Autor:
Ting Fu, Tao Huan, Gibraan Rahman, Hui Zhi, Zhenjiang Xu, Tae Gyu Oh, Jian Guo, Sally Coulter, Anupriya Tripathi, Cameron Martino, Justin L. McCarville, Qiyun Zhu, Fritz Cayabyab, Brian Low, Mingxiao He, Shipei Xing, Fernando Vargas, Ruth T. Yu, Annette Atkins, Christopher Liddle, Janelle Ayres, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight, Ronald M. Evans
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112997- (2023)
Summary: Colorectal cancer (CRC) is driven by genomic alterations in concert with dietary influences, with the gut microbiome implicated as an effector in disease development and progression. While meta-analyses have provided mechanistic insight into
Externí odkaz:
https://doaj.org/article/958122a9c5d843b58513ee7535fcecb3
Autor:
Martial Rey, Menglin Yang, Linda Lee, Ye Zhang, Joey G. Sheff, Christoph W. Sensen, Hynek Mrazek, Petr Halada, Petr Man, Justin L. McCarville, Elena F. Verdu, David C. Schriemer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/cdeaaca055624b1c950a6193509e26f3
Autor:
Karina K. Sanchez, Katia Troha, Andre Mu, Samuel E. Redford, Justin L. McCarville, Arianna Insenga, Sarah Stengel, Yujung Michelle Lee, Janelle S. Ayres
Publikováno v:
Infect Immun
To combat infections, hosts employ a combination of antagonistic and cooperative defense strategies. The former refers to pathogen killing mediated by resistance mechanisms, while the latter refers to physiological defense mechanisms that promote hos
Autor:
Justin L. McCarville, Janelle S. Ayres
Publikováno v:
Immunity
Different effector arms of the immune system are optimized to protect from different classes of pathogens. In some cases, pathogens manipulate the host immune system to promote the wrong type of effector response – a phenomenon known as immune devi
Publikováno v:
Annual review of immunology. 38
Metabolism is one of the strongest drivers of interkingdom interactions—including those between microorganisms and their multicellular hosts. Traditionally thought to fuel energy requirements and provide building blocks for biosynthetic pathways, m
Autor:
Justin L. McCarville, Janelle S. Ayres
Publikováno v:
Cell Metabolism. 30:409-411
During infection, disease tolerance promotes host health without killing the pathogen. In a recent issue of Cell, Luan et al. (2019) identify GDF15 as a central regulator of disease tolerance of bacterial and viral challenges, while preventing cardia
Autor:
Edgardo Smecuol, Suzanne Hansen, Alexa Mordhorst, Maria Ines Pinto-Sanchez, Justin L. McCarville, Gary L. Norman, Daniel Basra, Elena F. Verdu, David Armstrong, Premysl Bercik, Armin Alaedini, Ekatherina Ignatova, Rajka Borojevic, Joseph A. Murray, Giada De Palma, Andrea Nardelli, Detlef Schuppan, Natalia Causada Calo, Julio C. Bai, Alberto Caminero, Melanie Uhde, Paul Moayyedi, Stephen M. Collins
Publikováno v:
Clinical Gastroenterology and Hepatology. 19:2343-2352.e8
Background & Aims Many patients with irritable bowel syndrome (IBS) perceive that their symptoms are triggered by wheat-containing foods. We assessed symptoms and gastrointestinal transit before and after a gluten-free diet (GFD) in unselected patien
Autor:
Elena F. Verdu, Steve P. Bernier, Alexandra R. Herrán, Alberto Caminero, Chad W. Johnston, Amy K. Russell, Heather J. Galipeau, Jennifer Jury, Michael G. Surette, Justin L. McCarville, Javier Casqueiro, Detlef Schuppan, Jason A. Tye-Din, Nathan A. Magarvey
Publikováno v:
Gastroenterology. 151:670-683
Background & Aims Partially degraded gluten peptides from cereals trigger celiac disease (CD), an autoimmune enteropathy occurring in genetically susceptible persons. Susceptibility genes are necessary but not sufficient to induce CD, and additional