Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Justin L Grobe"'
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0250807 (2021)
Excessive sodium intake is known to increase the risk for hypertension, heart disease, and stroke. Individuals who are more susceptible to the effects of high salt are at higher risk for cardiovascular diseases even independent of their blood pressur
Externí odkaz:
https://doaj.org/article/264e6700e71a4992ac880d793ce758f1
Autor:
Deng-Fu Guo, Huxing Cui, Qihong Zhang, Donald A Morgan, Daniel R Thedens, Darryl Nishimura, Justin L Grobe, Val C Sheffield, Kamal Rahmouni
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005890 (2016)
Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determi
Externí odkaz:
https://doaj.org/article/92514b30f821463d935507322f537a10
Autor:
Peng Shi, Justin L Grobe, Fiona A Desland, Guannan Zhou, Xiao Z Shen, Zhiying Shan, Meng Liu, Mohan K Raizada, Colin Sumners
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e92937 (2014)
Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of th
Externí odkaz:
https://doaj.org/article/d93d21cf559d4c7b9352cb6f4675f0a3
Autor:
Maria Alicia Carrillo-Sepulveda, Henry L Keen, Deborah R Davis, Justin L Grobe, Curt D Sigmund
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103786 (2014)
Peroxisome proliferator activated receptor γ (PPARγ) has been reported to play a protective role in the vasculature; however, the underlying mechanisms involved are not entirely known. We previously showed that vascular smooth muscle-specific overe
Externí odkaz:
https://doaj.org/article/afcd487d48c047aeb58c32d084f1394e
Autor:
Kirthikaa Balapattabi, Yavuz Yavuz, Jingwei Jiang, Guorui Deng, Natalia M. Mathieu, McKenzie L. Ritter, Megan A. Opichka, John J. Reho, John D. McCorvy, Pablo Nakagawa, Lisa L. Morselli, Gary C. Mouradian, Jr., Deniz Atasoy, Huxing Cui, Matthew R. Hodges, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112935- (2023)
Summary: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons contribute to the integrati
Externí odkaz:
https://doaj.org/article/232d89e1a4584d099a23a192408018ec
Autor:
Valerie A. Wagner, Guorui Deng, Kristin E. Claflin, McKenzie L. Ritter, Huxing Cui, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe, Anne E. Kwitek
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
A common preclinical model of hypertension characterized by low circulating renin is the “deoxycorticosterone acetate (DOCA)-salt” model, which influences blood pressure and metabolism through mechanisms involving the angiotensin II type 1 recept
Externí odkaz:
https://doaj.org/article/41540d841a564460be2c9f431689fc37
Autor:
McKenzie L, Ritter, Guorui, Deng, John J, Reho, Yue, Deng, Sarah A, Sapouckey, Megan A, Opichka, Kirthikaa, Balapattabi, Kelsey K, Wackman, Daniel T, Brozoski, Ko-Ting, Lu, William J, Paradee, Katherine N, Gibson-Corley, Huxing, Cui, Pablo, Nakagawa, Lisa L, Morselli, Curt D, Sigmund, Justin L, Grobe
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(12)
RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in theTo study cell-specific functions of RGS2, a novel gene-targeted mouse harboring a conditional allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::827128aade704ab416b60eeea61e3c12
https://pubmed.ncbi.nlm.nih.gov/36259376
https://pubmed.ncbi.nlm.nih.gov/36259376
Autor:
Vanessa Oliveira, John J. Reho, Kirthikaa Balapattabi, McKenzie L. Ritter, Natalia M. Mathieu, Megan A. Opichka, Ko-Ting Lu, Connie C. Grobe, Sebastião D. Silva, Kelsey K. Wackman, Pablo Nakagawa, Jeffrey L. Segar, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(4)
The renin-angiotensin system (RAS) within the brain is implicated in the control of fluid and electrolyte balance, autonomic functions, blood pressure, and energy expenditure. Mouse models are increasingly used to explore these mechanisms; however, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef6d9a59b150d36370d8b9c9e49659e
https://pubmed.ncbi.nlm.nih.gov/35816717
https://pubmed.ncbi.nlm.nih.gov/35816717
Autor:
Natalia M. Mathieu, Pablo Nakagawa, Connie C. Grobe, John J. Reho, Daniel T. Brozoski, Ko-Ting Lu, Kelsey K. Wackman, McKenzie L. Ritter, Jeffrey L. Segar, Justin L. Grobe, Curt D. Sigmund
Publikováno v:
Hypertension. 79:2480-2492
Background: GPCRs (G protein–coupled receptors) are implicated in blood pressure (BP) and fluid intake regulation. There is a developing concept that these effects are mediated by both canonical G protein signaling and noncanonical β-arrestin medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3908a1b216e1d81536e3beb97c3ad3
https://doi.org/10.1161/hypertensionaha.122.19863
https://doi.org/10.1161/hypertensionaha.122.19863
Autor:
Valerie A Wagner, Katie L Holl, Karen C Clark, John J Reho, Melinda R Dwinell, Hans-Joachim Lehmler, Hershel Raff, Justin L Grobe, Anne E Kwitek
Publikováno v:
Toxicological Sciences.
Environmental bisphenol compounds like bisphenol F (BPF) are endocrine disrupting chemicals (EDC) affecting adipose and classical endocrine systems. Genetic factors that influence EDC exposure outcomes are poorly understood and are unaccounted variab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c91c1c35152e256a8fd50e94fc7a5e
https://doi.org/10.1093/toxsci/kfad046
https://doi.org/10.1093/toxsci/kfad046