Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Justin L, Harper"'
Autor:
Amit A. Upadhyay, Elise G. Viox, Timothy N. Hoang, Arun K. Boddapati, Maria Pino, Michelle Y.-H. Lee, Jacqueline Corry, Zachary Strongin, David A. Cowan, Elizabeth N. Beagle, Tristan R. Horton, Sydney Hamilton, Hadj Aoued, Justin L. Harper, Christopher T. Edwards, Kevin Nguyen, Kathryn L. Pellegrini, Gregory K. Tharp, Anne Piantadosi, Rebecca D. Levit, Rama R. Amara, Simon M. Barratt-Boyes, Susan P. Ribeiro, Rafick P. Sekaly, Thomas H. Vanderford, Raymond F. Schinazi, Mirko Paiardini, Steven E. Bosinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
‘The induction and coordination of immune cells in response to SARS-CoV-2 infection are critical in the immunopathology of COVID-19. Here the authors use a rhesus macaque model of SARS-CoV-2 infection and show key populations of macrophage drive th
Externí odkaz:
https://doaj.org/article/c564e47315c745239eaae99118b06bd0
Autor:
Mykola Pinkevych, Steffen S Docken, Afam A Okoye, Christine M Fennessey, Gregory Q Del Prete, Maria Pino, Justin L Harper, Michael R Betts, Mirko Paiardini, Brandon F Keele, Miles P Davenport
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011660 (2023)
One approach to 'functional cure' of HIV infection is to induce durable control of HIV replication after the interruption of antiretroviral therapy (ART). However, the major factors that determine the viral 'setpoint' level after treatment interrupti
Externí odkaz:
https://doaj.org/article/3ae2558a10c74188bef570d4a345b7f7
Autor:
Maria Pino, Amélie Pagliuzza, M. Betina Pampena, Claire Deleage, Elise G. Viox, Kevin Nguyen, Inbo Shim, Adam Zhang, Justin L. Harper, Sadia Samer, Colin T. King, Barbara Cervasi, Kiran P. Gill, Stephanie Ehnert, Sherrie M. Jean, Michael L. Freeman, Jeffrey D. Lifson, Deanna Kulpa, Michael R. Betts, Nicolas Chomont, Michael M. Lederman, Mirko Paiardini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Although antiretroviral therapy (ART) is able to successfully suppress plasma viremia in most people living with HIV, ART withdrawal typically results in viral replication and rebound. Authors investigate the effect, in terms of delay in viral replic
Externí odkaz:
https://doaj.org/article/02897c95d48247e0867184e05e8cc7b9
Autor:
Zachary Strongin, Timothy N Hoang, Gregory K Tharp, Andrew R Rahmberg, Justin L Harper, Kevin Nguyen, Lavinia Franchitti, Barbara Cervasi, Max Lee, Zhan Zhang, Eli A Boritz, Guido Silvestri, Vincent C Marconi, Steven E Bosinger, Jason M Brenchley, Deanna A Kulpa, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010723 (2022)
Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive pathogenesis during acute and chronic infection prior to ART initiation and continued persistence in a
Externí odkaz:
https://doaj.org/article/0d173f19d60843dc8264274e0962880c
Autor:
Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Le Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin, Michaela Müller-Trutwin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependen
Externí odkaz:
https://doaj.org/article/7c09c41f3ce44f41931d8a99a69c119f
Autor:
Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L Harper, Colin T King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A Delman, Theron Stuart, Michael Lowe, Jason M Brenchley, Cynthia A Derdeyn, Kirk Easley, Rafick P Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C Marconi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009825 (2021)
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed
Externí odkaz:
https://doaj.org/article/067e37f438b34fd7827433be61b176ba
Autor:
Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
Autor:
Maura Statzu, Wang Jin, Emily J. Fray, Andrew Kam Ho Wong, Mithra R. Kumar, Elizabeth Ferrer, Steffen S. Docken, Mykola Pinkevych, Julia B. McBrien, Christine M. Fennessey, Brandon F. Keele, Shan Liang, Justin L. Harper, Simona Mutascio, Lavinia Franchitti, Hong Wang, Davide Cicetti, Steven E. Bosinger, Diane G. Carnathan, Thomas H. Vanderford, David M. Margolis, J. Victor Garcia-Martinez, Ann Chahroudi, Mirko Paiardini, Janet Siliciano, Miles P. Davenport, Deanna A. Kulpa, Robert S. Siliciano, Guido Silvestri
Publikováno v:
Nature Microbiology. 8:299-308
Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While reservoir formation begins during acute infection, the mechanisms
Autor:
Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L Harper, Colin T King, Luca Micci, Barbara Cervasi, Joseph C Mudd, Kiran P Gill, Sherrie M Jean, Kirk Easley, Guido Silvestri, Jacob D Estes, Constantinos Petrovas, Michael M Lederman, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008081 (2019)
Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir.
Externí odkaz:
https://doaj.org/article/317b112ab6a540088ba22b5560bb1102
Autor:
Christina Mallarino-Haeger, Maria Pino, Elise G. Viox, Amélie Pagliuzza, Colin T. King, Kevin Nguyen, Justin L. Harper, Sol del Mar Aldrete, Barbara Cervasi, Keith A. Delman, Michael C. Lowe, Nicolas Chomont, Vincent C. Marconi, Mirko Paiardini
Publikováno v:
Journal of Virology. 97
This study provides new insights into the contributions of different CD4 + and CD8 + T-cell subsets to the anatomic differences between LN and blood in individuals with HIV who have optimal versus suboptimal CD4 + T-cell recovery. To our knowledge, t