Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Justin Komguep Nono"'
Autor:
Paballo Mosala, Thabo Mpotje, Nada Abdel Aziz, Hlumani Ndlovu, Fungai Musaigwa, Justin Komguep Nono, Frank Brombacher
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Schistosomiasis remains the most devastating neglected tropical disease, affecting over 240 million people world-wide. The disease is caused by the eggs laid by mature female worms that are trapped in host’s tissues, resulting in chronic Th2 driven
Externí odkaz:
https://doaj.org/article/9d90f103c08e4ebaa2b8f2b3c4cb4805
Autor:
Mireille Kameni, Fungai Musaigwa, Leonel Meyo Kamguia, Severin Donald Kamdem, Gladice Mbanya, Poppy H L Lamberton, Justin Komguep Nono
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 3, p e0012009 (2024)
Schistosomiasis is the second most widespread parasitic disease affecting humans. A key component of today's infection control measures is the diagnosis and monitoring of infection, informing individual- and community-level treatment. However, newly
Externí odkaz:
https://doaj.org/article/b896eb89429c4de9a90b2214f08728b9
Autor:
Fungai Musaigwa, Severin Donald Kamdem, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, De'Broski R Herbert, Frank Brombacher, Justin Komguep Nono
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010327 (2022)
Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individu
Externí odkaz:
https://doaj.org/article/5c02e8ecc6b54e17be0e68838fc17665
Autor:
Justin Komguep Nono, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, Fungai Musaigwa, Lerato Hlaka, Thomas Spangenberg, Frank Brombacher
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Beyond transient control of the infection, additional benefits of mass drug administration of praziquantel in endemic communities have been suggested in communities but not mechanistically investigated experimentally. The present study sought to eval
Externí odkaz:
https://doaj.org/article/ee9bab584e164309a33b774665e0974a
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
BackgroundAlveolar echinococcosis (AE), caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis, is a chronic zoonosis associated with significant modulation of the host immune response. A role of regulatory T-cells (Tr
Externí odkaz:
https://doaj.org/article/7e5d76bc3f7a4bd398038db59ea732d0
Autor:
Severin Donald Kamdem, Francis Konhawa, Erve Martial Kuemkon, Leonel Meyo Kamguia, Gladys K. Tchanana, Frungwa Nche, Alim Oumarou, Mamadou Hamza, Yasmine Ouratou, Mariette Nzoku Tcheutchoua, René Ghislain Essomba, Marie Paule Ngogang, Michel Kengne, Palmer Masumbe Netongo, Bienvenu Etogo Ondigui, Marie Claire Okomo Assoumou, Frank Brombacher, Justin Komguep Nono
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, mala
Externí odkaz:
https://doaj.org/article/0e366057631b406ca826fbf10377a024
Autor:
Hlumani Ndlovu, Justin Komguep Nono, Nada Abdel Aziz, Natalie Eva Nieuwenhuizen, Frank Brombacher
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Schistosomiasis (bilharzia) is a parasitic helminth disease that can cause severe inflammatory pathology leading to organ damage in humans. Failure of the host to regulate egg-driven granulomatous inflammation causes host morbidity during chronic inf
Externí odkaz:
https://doaj.org/article/194cb7cb25e14e2d9527aa207de19b0f
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomoni
Externí odkaz:
https://doaj.org/article/c8f04624de4e4238a6d2a84f105f62be
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2005850 (2018)
Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In vivo, interleukin-4 (IL-4)-mediated signaling via IL-4 receptor alpha (IL-4Rα) mediates T
Externí odkaz:
https://doaj.org/article/73e06cd9c3734891982b90778d1c6c83
Autor:
Justin Komguep Nono, Severin Donald Kamdem, Palmer Masumbe Netongo, Smritee Dabee, Michael Schomaker, Alim Oumarou, Frank Brombacher, Roger Moyou-Somo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background and Methods: Schistosomiasis is debilitating and reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration (MDA) is used in schoolchildren to reduce transmission of S. haematobium and S. mansoni. The
Externí odkaz:
https://doaj.org/article/50f38609733b44289b90902271400d68