Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Justin K Y Hong"'
Autor:
Morgan B. Giles, Justin K. Y. Hong, Yayuan Liu, Jie Tang, Tinghui Li, Avital Beig, Anna Schwendeman, Steven P. Schwendeman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Encapsulation of bioactive peptides in slow-release particles is complex and relies on organic solvents. Here, the authors absorb peptides in a polymer phase from water, creating a simple low-cost encapsulation process in a class of polymer depot.
Externí odkaz:
https://doaj.org/article/ea35ff6412aa4f5eb10b6b0ae683a965
Autor:
Kai Zheng, Diya Ren, Y. John Wang, Wayne Lilyestrom, Thomas Scherer, Justin K. Y. Hong, Junyan A. Ji
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://doaj.org/article/e4a9f9583ec54a609836950196e707ce
Autor:
Steven P. Schwendeman, Bin Qin, Justin K Y Hong, Yan Wang, Alexander Benet, Jennifer Walker, Avital Beig, Jukyung Kang, Aishwarya Chandrashekar, Anna Schwendeman, Tinghui Li, Rose Ackermann
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 158:401-409
Bydureon® (Bdn) is a once-weekly injectable long-acting release (LAR) product for adults with type 2 diabetes based on PLGA microspheres encapsulating the glucagon like peptide (GLP-1) analog, exenatide. Despite its widespread use in type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85086dc3f3c3d1b9afa32012171c69cb
https://doi.org/10.1016/j.ejpb.2020.10.008
https://doi.org/10.1016/j.ejpb.2020.10.008
Autor:
Li Li, Steven P. Schwendeman, Karl F. Olsen, Nian-Qiu Shi, Jie Tang, Rose Ackermann, Bin Qin, Jia Zhou, Jennifer Walker, Yan Wang, Justin K Y Hong, Anna Schwendeman
Publikováno v:
Journal of Controlled Release. 321:756-772
A spray drying technique was developed to prepare injectable and biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulating a model luteinizing hormone-releasing hormone agonist (LHRHa)-based peptide, leuprolide. Various spray dryi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827844dce0c260e7fba4758608904efa
https://doi.org/10.1016/j.jconrel.2020.01.023
https://doi.org/10.1016/j.jconrel.2020.01.023
Autor:
Linglin Feng, Jennifer Walker, Steven P. Schwendeman, Yan Wang, Avital Beig, Rose Ackermann, Justin K Y Hong, Tinghui Li
Publikováno v:
Drug delivery and translational research. 12(3)
Sandostatin long-acting release® (SLAR) is a long-acting injectable somatostatin analogue formulation composed of octreotide encapsulated in glucose-initiated poly(lactic-co-glycolic acid) (PLGA) microspheres. Despite the end of patent protection, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b7bd9e7f0722311940c50fa839ac27
https://pubmed.ncbi.nlm.nih.gov/34215997
https://pubmed.ncbi.nlm.nih.gov/34215997
Autor:
Junyan A Ji, Y John Wang, Kai Zheng, Justin K Y Hong, Diya Ren, Wayne Lilyestrom, Thomas M. Scherer
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2d69f2f72850333e44c5e3c419abd
https://pubmed.ncbi.nlm.nih.gov/33921206
https://pubmed.ncbi.nlm.nih.gov/33921206
Autor:
Steven P. Schwendeman, Justin K Y Hong
Publikováno v:
Biomacromolecules. 21(10)
Cationic peptides are well known to readily bind poly(lactic-co-glycolic acids) (PLGAs) with a carboxylic acid (-COOH) end group, which poses a significant challenge to develop PLGA-based delivery systems for peptide therapeutics. This binding has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda36495f8ecc48c2b7e43d434e63e32
https://pubmed.ncbi.nlm.nih.gov/32885949
https://pubmed.ncbi.nlm.nih.gov/32885949
Autor:
Bin Qin, Rose Ackermann, Linglin Feng, Jennifer Walker, Avital Beig, Steven P. Schwendeman, Justin K Y Hong, Yan Wang, Tinghui Li
Publikováno v:
Molecular pharmaceutics. 17(11)
Sandostatin LAR (SLAR) is an injectable long-acting release (LAR) microsphere formulation for octreotide based on a biodegradeable glucose star copolymer of d,l-lactic and glycolic acids (PLGA-glu), which is primarily used for the treatment of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcea8e512a03e2a4ba01075bee2e70e
https://pubmed.ncbi.nlm.nih.gov/32876463
https://pubmed.ncbi.nlm.nih.gov/32876463
Autor:
Karl F. Olsen, Steven P. Schwendeman, Jia Zhou, Rose Ackermann, Yan Wang, Jennifer Walker, Justin K Y Hong
Publikováno v:
Molecular pharmaceutics. 17(5)
The 1-month Lupron Depot (LD) is a 75/25 acid-capped poly(lactic-co-glycolic acid) (PLGA) microsphere product encapsulating water-soluble leuprolide acetate with no generic products available in the U.S. Composition-equivalent PLGA microsphere formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c10464f8443331a0ed4e3447b87cf7
https://pubmed.ncbi.nlm.nih.gov/32074448
https://pubmed.ncbi.nlm.nih.gov/32074448
Autor:
Lukasz J. Ochyl, James J. Moon, Steven P. Schwendeman, Justin K Y Hong, J. Maxwell Mazzara, Mark R. Prausnitz
Publikováno v:
Bioengineering & Translational Medicine
There is an urgent need to reduce reliance on hypodermic injections for many vaccines to increase vaccination safety and coverage. Alternative approaches include controlled release formulations, which reduce dosing frequencies, and utilizing alternat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8305c56beb9ac8251316f918f1a90b
http://europepmc.org/articles/PMC6336668
http://europepmc.org/articles/PMC6336668