Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Justin K, Ichida"'
Autor:
Eric Hendricks, Alicia M. Quihuis, Shu-Ting Hung, Jonathan Chang, Nomongo Dorjsuren, Balint Der, Kim A. Staats, Yingxiao Shi, Naomi S. Sta Maria, Russell E. Jacobs, Justin K. Ichida
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112983- (2023)
Summary: Genetic mutations that cause adult-onset neurodegenerative diseases are often expressed during embryonic stages, but it is unclear whether they alter neurodevelopment and how this might influence disease onset. Here, we show that the most co
Externí odkaz:
https://doaj.org/article/461d2ae4a12545c4b1a169e2bb068ec8
Autor:
Wataru Isono, Tomoyuki Kawasaki, Justin K. Ichida, Takuya Ayabe, Osamu Hiraike, Akihiro Umezawa, Hidenori Akutsu
Publikováno v:
Regenerative Therapy, Vol 15, Iss , Pp 161-168 (2020)
Conventional human pluripotent stem cells (hPSCs), known for being in a primed state, are pivotal for both basic research and clinical applications since such cells produce various types of differentiated cells. Recent reports on PSCs shed light on t
Externí odkaz:
https://doaj.org/article/02a8aa2ac3e14e85b87474680515cbe8
Autor:
Jeffrey W. Santoso, Xiling Li, Divya Gupta, Gio C. Suh, Eric Hendricks, Shaoyu Lin, Sarah Perry, Justin K. Ichida, Dion Dickman, Megan L. McCain
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 036101-036101-16 (2021)
To develop effective cures for neuromuscular diseases, human-relevant in vitro models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture motor neurons
Externí odkaz:
https://doaj.org/article/6fd450d7c35443ed846926f94cea84d9
Autor:
Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, Israel Hernandez, Valerie Hennes, Martin Kampmann
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 939-955 (2019)
Summary: Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal domina
Externí odkaz:
https://doaj.org/article/598d132842794126ace928eb080d817b
Autor:
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105228- (2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Externí odkaz:
https://doaj.org/article/9e65354b9c964af3a16790973ddace6f
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100068- (2020)
Summary: Pulmonary neuroendocrine cells (PNECs) are sensory cells within the lung airway epithelia. Here, we provide a detailed protocol for generating induced PNECs (iPNECs) from human induced pluripotent stem cells (iPSCs). The cellular and molecul
Externí odkaz:
https://doaj.org/article/b7832cccd3e343658b9fd64571eb1abe
Autor:
Pooja Hor, Vasu Punj, Ben A. Calvert, Alessandra Castaldi, Alyssa J. Miller, Gianni Carraro, Barry R. Stripp, Steven L. Brody, Jason R. Spence, Justin K. Ichida, Amy L. Ryan (Firth), Zea Borok
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity (
Externí odkaz:
https://doaj.org/article/3b48a752bd614d27a8fbdb9eff4eef14
Autor:
Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel H. Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama
Publikováno v:
The Journal of Neuroscience. 43:333-345
Hexanucleotide repeat expansion (HRE) withinC9orf72is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfdbe4480f987d12b252f86e4c33446
https://doi.org/10.1523/jneurosci.1448-22.2022
https://doi.org/10.1523/jneurosci.1448-22.2022
Autor:
Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 43, iss 2
Hexanucleotide repeat expansion (HRE) within C9orf72 is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26db290663368430e8978af72589564d
https://escholarship.org/uc/item/7jr289cm
https://escholarship.org/uc/item/7jr289cm
Autor:
Juan A. Ortega, Ivan R. Sasselli, Marco Boccitto, Andrew C. Fleming, Tyler R. Fortuna, Yichen Li, Kohei Sato, Tristan D. Clemons, Elizabeth L. Daley, Thao P. Nguyen, Eric N. Anderson, Justin K. Ichida, Udai B. Pandey, Sandra Wolin, Samuel I. Stupp, Evangelos Kiskinis
Amyotrophic lateral sclerosis and frontotemporal dementia patients with a hexanucleotide repeat expansion inC9ORF72(C9-HRE) accumulate poly-GR and poly-PR aggregates. The pathogenicity of these arginine-rich dipeptide repeats (R-DPRs) is thought to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e27b2598f16fa7130cbc75eb630d06c
https://doi.org/10.1101/2022.12.30.522259
https://doi.org/10.1101/2022.12.30.522259