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cGAS is an evolutionarily conserved enzyme that plays a pivotal role in immune defense against microbial infection1-3. In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)4,5 , which initiates a signaling cascade leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0609adf73a4c57865f1d90e98332a7a5
https://doi.org/10.21203/rs.3.rs-1578554/v1
https://doi.org/10.21203/rs.3.rs-1578554/v1
Autor:
Zhijian J. Chen, Justin Jenson
Publikováno v:
Nature. 586:363-364
The cGAS–STING signalling pathway, which has a key role in antiviral immune responses in mammals, is found to have originated as an immune-defence system that protects bacteria against viral infection. The cGAS–STING defence pathway originated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22a85f3819cc96399103a2e37d9e0bc
https://doi.org/10.1038/d41586-020-02712-8
https://doi.org/10.1038/d41586-020-02712-8
