Výsledky vyhledávání - "Justin J J Leahy"

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

Autor: Bernard T. Golding, Nicola J. Curtin, Marine Desage El-Murr, Roger J. Griffin, Martin Stockley, Laurent Rigoreau, Graeme C. M. Smith, Ian R. Hardcastle, Xiao-Ling Fan Cockcroft, Caroline Richardson, Justin J J Leahy

Publikováno v: Journal of medicinal chemistry. 48(24)

Structure-activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined for substituted chromen-4-ones. For the 2-amino-substituted benzo[h]chromen-4-ones, a morpholine substituent at this position was essential for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706da803d15339b6f42fa26768a912bf
https://pubmed.ncbi.nlm.nih.gov/16302822

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Identification of a Highly Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor (NU7441) by Screening of Chromenone Libraries

Autor: Ian R. Hardcastle, Caroline Richardson, Justin J. J. Leahy, Roger J. Griffin, Bernard T. Golding, Laurent Rigoreau, Graeme C. M. Smith

Publikováno v: ChemInform. 36

A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). These stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f54260d7bb2a6fcf95456b2a36658e9
https://doi.org/10.1002/chin.200515243

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Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro

Autor: Bernard T. Golding, Niall M. B. Martin, Laurent Rigoreau, Graeme C. M. Smith, Justin J. J. Leahy, Gabriele Fontana, Sophie Guiard, Ian R. Hardcastle, Caroline Richardson, Roger J. Griffin, Martin Stockley

Publikováno v: Journal of medicinal chemistry. 48(2)

A diverse range of chromen-2-one, chromen-4-one and pyrimidoisoquinolin-4-one derivatives was synthesized and evaluated for inhibitory activity against the DNA repair enzyme DNA-dependent protein kinase (DNA-PK), with a view to elucidating structure-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242a41df2a90ade56e88ccb0fc1d1481
https://pubmed.ncbi.nlm.nih.gov/15658870

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