Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Justin J Greenlee"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011815 (2023)
Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission. Little is known about the potential transmission of
Externí odkaz:
https://doaj.org/article/8ccd4ad15c464ba2add1606f4a5bec23
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246503 (2021)
Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously. The purpose of this study was to test the trans
Externí odkaz:
https://doaj.org/article/5f9e0b3032394f7583dbf0b330bb470a
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227487 (2020)
Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrPC) to pathogenic conformers (PrPSc), and the pathogenic forms accumulate i
Externí odkaz:
https://doaj.org/article/81853356354c4cfaaa0a9dce2f21bedb
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243009 (2020)
Scrapie, a prion disease of sheep, is highly resistant to conventional deactivation. Numerous methods to deactivate scrapie have been tested in laboratory animal models, and adequate autoclave treatment can reduce or remove the infectivity of some cl
Externí odkaz:
https://doaj.org/article/b50835f15ac3475ca4b4a4318f650998
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209106 (2018)
Scrapie is a naturally occurring transmissible spongiform encephalopathy of sheep and goats. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein to pathogenic β-rich conformers (PrPSc) that accumulate in higher
Externí odkaz:
https://doaj.org/article/714f6febad8a4e7c9f59b441a2482b06
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172391 (2017)
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for
Externí odkaz:
https://doaj.org/article/e0110e5279c4445886033773e2517bc5
Autor:
Jo Moore, M. Heather West Greenlee, Jodi D. Smith, Catherine E. Vrentas, Eric M Nicholson, Justin J Greenlee
Publikováno v:
Frontiers in Veterinary Science, Vol 3 (2016)
In 2006, a case of H-type bovine spongiform encephalopathy (BSE-H) was diagnosed in a cow that was associated with a heritable polymorphism in the bovine prion protein gene (PRNP) resulting in a lysine for glutamine amino acid substitution at codon 2
Externí odkaz:
https://doaj.org/article/6e6e54c85cbe4cc998dbd9c95e3b71ab
Autor:
M Heather West Greenlee, Jodi D Smith, Ekundayo M Platt, Jessica R Juarez, Leo L Timms, Justin J Greenlee
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119431 (2015)
Bovine spongiform encephalopathy (BSE) belongs to a group of fatal, transmissible protein misfolding diseases known as transmissible spongiform encephalopathies (TSEs). All TSEs are caused by accumulation of misfolded prion protein (PrPSc) throughout
Externí odkaz:
https://doaj.org/article/484ff9972aa04e5f8e621323889f61f0
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108029 (2014)
Sheep scrapie is a transmissible spongiform encephalopathy that can be transmitted horizontally. The prion protein gene (PRNP) profoundly influences the susceptibility of sheep to the scrapie agent and the tissue levels and distribution of PrPSc in a
Externí odkaz:
https://doaj.org/article/f84c015b81b04f95a479b6a73e0fda1a
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43060 (2012)
Transmissible spongiform encephalopathies (TSEs), including scrapie in sheep (Ovis aries), are fatal neurodegenerative diseases caused by the misfolding of the cellular prion protein (PrP(C)) into a â-rich conformer (PrP(Sc)) that accumulates into h
Externí odkaz:
https://doaj.org/article/fd1c0a5342bb469db4c04cd6110afb0c