Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Justin I, Montgomery"'
Autor:
Dominic D.G Owens, Matthew E.R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Martin P. Schwalm, Raquel A.C Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F. Calabrese, Matthew S. Dowling, Jisun Lee, Justin I. Montgomery, Thomas N. O’Connell, Chakrapani Subramanyam, Feng Wang, Matthieu Schapira, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A. Lajoie, Dalia Barsyte-Lovejoy, Dafydd R. Owen, Caroline Schild-Poulter, Cheryl H. Arrowsmith
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via the substrate receptor GID4. Recently, focus has turned to this complex as a potential mediator of targeted protein degradation, but the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756b8bd8412abe2d17623cbc6ce6d79d
https://doi.org/10.1101/2023.01.17.524225
https://doi.org/10.1101/2023.01.17.524225
Autor:
Xidong Feng, Ye Che, Adam M. Gilbert, Reto Horst, Kris A. Borzilleri, Matthew Merrill Hayward, Carolyn A. Leverett, James Schiemer, Yilin Meng, Justin I. Montgomery, Matthew F. Calabrese, Mark C. Noe, Daniel P. Uccello, Stephen P. Brown, Matthew Frank Brown, Yingrong Xu
Publikováno v:
Nature Chemical Biology. 17:152-160
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783031186288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847c2128b0f8d993d43a92df10815f38
https://doi.org/10.1007/7355_2022_148
https://doi.org/10.1007/7355_2022_148
Publikováno v:
Journal of chemical information and modeling. 62(9)
By analyzing data sets of replicate DNA-Encoded Library (DEL) selections, an approach for estimating the noise level of the experiment has been developed. Using a logarithm transformation of the number of counts associated with each compound and a su
Autor:
Timothy L. Foley, Anokha S. Ratnayake, Justin Bellenger, Brian M. Paegel, Mark Edward Flanagan, Jillian G. Johnson, Justin I. Montgomery, Justin Donald Smith
Publikováno v:
ACS Comb Sci
DNA-Encoded Chemical Library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the identification of “DNA-compatible” reaction conditions is critical for the development of DE
Autor:
Andrew P. Tomaras, Craig J. McPherson, Michael Kuhn, Arlene Carifa, Lisa Mullins, David George, Charlene Desbonnet, Tess M. Eidem, Justin I. Montgomery, Matthew F. Brown, Usa Reilly, Alita A. Miller, John P. O’Donnell
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are
Externí odkaz:
https://doaj.org/article/e21fa61d149c45b28c2a269c230984e1
Autor:
W. Scott Hopkins, Jarrod Psutka, Justin I. Montgomery, Chang Liu, Ahdia Anwar, J. C. Yves Le Blanc, Jeff Crouse, John S. Janiszewski, Gilles H. Goetz, Stephen W. C. Walker, J. Larry Campbell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Nature Communications
Nature Communications
The fast and accurate determination of molecular properties is highly desirable for many facets of chemical research, particularly in drug discovery where pre-clinical assays play an important role in paring down large sets of drug candidates. Here,
Autor:
Kathleen A. Farley, Parag Sahasrabudhe, Manjinder S. Lall, Justin Bellenger, Bruce Allen Lefker, Xidong Feng, Timothy L. Foley, Scott L. Hultgren, Dominik K. Kölmel, Jinqiao Wan, Bo Liu, Justin I. Montgomery, Anokha S. Ratnayake, Mark Edward Flanagan, Shi Chen, Laura J. Byrnes, Andre Shavnya, Tim F. Ryder
Publikováno v:
Bioorganicmedicinal chemistry. 41
The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology. DNA-encoded libraries (DELs) are typically screened by immobilized affinity selection and enriched library members
Autor:
Lin Lin, Brandon Tan, Paul Pantapalangkoor, Tiffany Ho, Beverlie Baquir, Andrew Tomaras, Justin I. Montgomery, Usa Reilly, Elsa G. Barbacci, Kristine Hujer, Robert A. Bonomo, Lucia Fernandez, Robert E. W. Hancock, Mark D. Adams, Samuel W. French, Virgil S. Buslon, Brad Spellberg
Publikováno v:
mBio, Vol 3, Iss 5 (2012)
ABSTRACT New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli (GNB), such as Acinetobacter baumannii. Toll-like receptor 4 (TLR4) was previously reported to enhance bacterial clearance of GNB, including A. baumannii. H
Externí odkaz:
https://doaj.org/article/98a27678de9b43609cdeb2a615fb073e
Autor:
James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
Publikováno v:
Nature chemical biology. 17(2)
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi