Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Justin Hwang"'
Autor:
Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, Sayed Matar, Atef Ali, Eddy Saad, Renee Maria Saliby, Paulo Cordeiro, Ziwei Zhang, Nourhan El Ahmar, Yasmin Nabil Laimon, Chris Labaki, Valisha Shah, Dory Freeman, Jillian O’Toole, Gwo-Shu Mary Lee, Justin Hwang, Mark Pomerantz, Sabina Signoretti, Eliezer M. Van Allen, Wanling Xie, Jacob E. Berchuck, Srinivas R. Viswanathan, David A. Braun, Toni K. Choueiri, Matthew L. Freedman, Sylvan C. Baca
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114350- (2024)
Summary: Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding o
Externí odkaz:
https://doaj.org/article/a9e18e74ab10487c9c8418746dfe9c2a
Autor:
Hannah E. Bergom, Laura A. Sena, Abderrahman Day, Benjamin Miller, Carly D. Miller, John R. Lozada, Nicholas Zorko, Jinhua Wang, Eugene Shenderov, Francisco Pereira Lobo, Fernanda Caramella-Pereira, Luigi Marchionni, Charles G. Drake, Tamara Lotan, Angelo M. De Marzo, Justin Hwang, Emmanuel S. Antonarakis
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who
Externí odkaz:
https://doaj.org/article/a63fc47e643a46939677c01b1b4e10df
ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems
Autor:
Hannah E. Bergom, Ashraf Shabaneh, Abderrahman Day, Atef Ali, Ella Boytim, Sydney Tape, John R. Lozada, Xiaolei Shi, Carlos Perez Kerkvliet, Sean McSweeney, Samuel P. Pitzen, Megan Ludwig, Emmanuel S. Antonarakis, Justin M. Drake, Scott M. Dehm, Charles J. Ryan, Jinhua Wang, Justin Hwang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and prior exposure to therapy. Here, we developed the Algorithm for Linking Activity Networks (ALAN)
Externí odkaz:
https://doaj.org/article/beba2e91e3c64bb1936e18c40ebe3097
Autor:
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-6 (2022)
Abstract B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation i
Externí odkaz:
https://doaj.org/article/4430f98cbc41482e987673e7579881aa
Autor:
Ralph E. White, Maxwell Bannister, Abderrahman Day, Hannah E. Bergom, Victor M. Tan, Justin Hwang, Hai Dang Nguyen, Justin M. Drake
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Prostate cancer (PCa) remains the most diagnosed non-skin cancer amongst the American male population. Treatment for localized prostate cancer consists of androgen deprivation therapies (ADTs), which typically inhibit androgen production and the andr
Externí odkaz:
https://doaj.org/article/2c4c23f36cda4974bca482b9155658b3
Autor:
Sean McSweeney, Hannah E Bergom, Anna Prizment, Susan Halabi, Nima Sharifi, Charles Ryan, Justin Hwang
Publikováno v:
Endocrine Oncology, Vol 2, Iss 1, Pp R51-R64 (2023)
The androgen receptor (AR) signaling pathway regulates the progression of prostate cancer (PC). Metastatic castration-resistant prostate cancer (mCRPC) patients generally receive AR-targeted therapies (ART) or androgen-deprivation therapies (ADT) wit
Externí odkaz:
https://doaj.org/article/4feaf425f0ba4298b20f1783e675039b
Autor:
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that cancers of n
Externí odkaz:
https://doaj.org/article/701d31e0fcdd484e84a5da699c9787f9
Autor:
Sylvan C. Baca, David Y. Takeda, Ji-Heui Seo, Justin Hwang, Sheng Yu Ku, Rand Arafeh, Taylor Arnoff, Supreet Agarwal, Connor Bell, Edward O’Connor, Xintao Qiu, Sarah Abou Alaiwi, Rosario I. Corona, Marcos A. S. Fonseca, Claudia Giambartolomei, Paloma Cejas, Klothilda Lim, Monica He, Anjali Sheahan, Amin Nassar, Jacob E. Berchuck, Lisha Brown, Holly M. Nguyen, Ilsa M. Coleman, Arja Kaipainen, Navonil De Sarkar, Peter S. Nelson, Colm Morrissey, Keegan Korthauer, Mark M. Pomerantz, Leigh Ellis, Bogdan Pasaniuc, Kate Lawrenson, Kathleen Kelly, Amina Zoubeidi, William C. Hahn, Himisha Beltran, Henry W. Long, Myles Brown, Eva Corey, Matthew L. Freedman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The molecular processes that lead to neuroendocrine prostate cancer after treating prostate adenocarcinoma (PRAD) are not well understood. Here the authors show that regulation by FOXA1 and changes in the epigenomic profile drive the transition from
Externí odkaz:
https://doaj.org/article/c9b61c7dcf794ef5947cc08ad8806fa3
Autor:
Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Wang, Evan Mun, Joyce T. O’Connell, Ying Huang, Katherine Labella, Jessica A. Talamas, Ji Li, Nina Ilic, Justin Hwang, Andrew L. Hong, Andrew O. Giacomelli, Ole Gjoerup, David E. Root, William C. Hahn
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109443- (2021)
Summary: Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor
Externí odkaz:
https://doaj.org/article/576815dfcfd2415692f51077629b4730
Autor:
Eileen Reilly, Justin Hwang
Publikováno v:
Case Reports in Infectious Diseases, Vol 2020 (2020)
Background. Listeria monocytogenes is historically a central nervous system pathogen of consideration in the very young, very old, and immune suppressed. Diagnosis of Listeria is based on positive bodily fluid culture or PCR testing. Cerebral edema i
Externí odkaz:
https://doaj.org/article/aeb2a8933c2b4971b2df2cd3a6a7bd54