Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Justin G. Wilkes"'
Autor:
Claire M. Doskey, Visarut Buranasudja, Brett A. Wagner, Justin G. Wilkes, Juan Du, Joseph J. Cullen, Garry R. Buettner
Publikováno v:
Redox Biology, Vol 10, Iss C, Pp 274-284 (2016)
Ascorbate (AscH−) functions as a versatile reducing agent. At pharmacological doses (P-AscH−; [plasma AscH−] ≥≈20 mM), achievable through intravenous delivery, oxidation of P-AscH− can produce a high flux of H2O2 in tumors. Catalase is th
Externí odkaz:
https://doaj.org/article/03863663ae414bff9582358298e07027
Publikováno v:
Antioxidants, Vol 6, Iss 3, p 66 (2017)
The incidence of pancreatic cancer is increasing as the population ages but treatment advancements continue to lag far behind. The majority of pancreatic cancer patients have a K-ras oncogene mutation causing a shift in the redox state of the cell, f
Externí odkaz:
https://doaj.org/article/1fa47f5a7fbd4508a78b41d70548e8b8
Autor:
Joseph J. Cullen, Bryan G. Allen, Heather A. Brown, Sandy Vollstedt, Kellie L. Bodeker, Daniel J. Berg, John M. Buatti, Douglas R. Spitz, Brianne R. O’Leary, Katherine Gibson-Corley, Juan Du, Brett A. Wagner, Garry R. Buettner, Samuel R. Schroeder, Justin G. Wilkes, Matthew S. Alexander
Radiation induced intestinal damage histology and collagen deposition information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007e7e320ffa5f1cd07d7839b75a3af6
https://doi.org/10.1158/0008-5472.22420140
https://doi.org/10.1158/0008-5472.22420140
Autor:
Joseph J. Cullen, Bryan G. Allen, Heather A. Brown, Sandy Vollstedt, Kellie L. Bodeker, Daniel J. Berg, John M. Buatti, Douglas R. Spitz, Brianne R. O’Leary, Katherine Gibson-Corley, Juan Du, Brett A. Wagner, Garry R. Buettner, Samuel R. Schroeder, Justin G. Wilkes, Matthew S. Alexander
The effect of ascorbate and catalase on clonogenic cell survival in PDAC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f06878d41c887f75876ffc980c62e2b
https://doi.org/10.1158/0008-5472.22420149
https://doi.org/10.1158/0008-5472.22420149
Autor:
Joseph J. Cullen, Bryan G. Allen, Heather A. Brown, Sandy Vollstedt, Kellie L. Bodeker, Daniel J. Berg, John M. Buatti, Douglas R. Spitz, Brianne R. O’Leary, Katherine Gibson-Corley, Juan Du, Brett A. Wagner, Garry R. Buettner, Samuel R. Schroeder, Justin G. Wilkes, Matthew S. Alexander
Chemoradiation therapy is the mainstay for treatment of locally advanced, borderline resectable pancreatic cancer. Pharmacologic ascorbate (P-AscH−, i.e., intravenous infusions of ascorbic acid, vitamin C), but not oral ascorbate, produces high pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa25ab339c827584a92b1e81f77dd312
https://doi.org/10.1158/0008-5472.c.6510567.v1
https://doi.org/10.1158/0008-5472.c.6510567.v1
Publikováno v:
Expert Opinion on Pharmacotherapy. 22:1443-1453
Introduction: Cutaneous melanoma brain metastases (MBM) are a major cause of morbidity and mortality. While cytotoxic agents, interferon, or interleukin-2, have been used with some success in extra...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7255bded3b6560d3f670ca2a96541ac4
https://doi.org/10.1080/14656566.2021.1900117
https://doi.org/10.1080/14656566.2021.1900117
Publikováno v:
Current Breast Cancer Reports. 12:82-89
Breast Ductal Carcinoma in Situ (DCIS) is an increasingly common diagnosis and already accounts for ~20% of screen-detected breast cancers. A subset of patients with DCIS will experience disease recurrence and some will die from breast cancer. Tailor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f136c183b0f56c212fe933a1ccd5cd06
https://doi.org/10.1007/s12609-020-00356-1
https://doi.org/10.1007/s12609-020-00356-1
Publikováno v:
Clinical advances in hematologyoncology : HO. 19(4)
In the vast majority of cases, cutaneous melanoma presents as localized disease and is treated with wide excision and sentinel lymph node biopsy, with shared decision making regarding completion lymph node dissection and adjuvant systemic therapy. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d1a356867f85e793a0412cb35a34630
https://pubmed.ncbi.nlm.nih.gov/33989273
https://pubmed.ncbi.nlm.nih.gov/33989273
Autor:
Zita A. Sibenaller, Matthew S. Alexander, Joseph J. Cullen, Adrienne R. Klinger, Susan Tsai, Brianne R. O'Leary, Claire M. Doskey, Justin G. Wilkes, Juan Du, Garry R. Buettner, Katherine N. Gibson-Corley
Publikováno v:
Clinical & Experimental Metastasis. 35:37-51
HIF-1α is a transcriptional regulator that functions in the adaptation of cells to hypoxic conditions; it strongly impacts the prognosis of patients with cancer. High-dose, intravenous, pharmacological ascorbate (P-AscH-), induces cytotoxicity and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::780cb6a7bab54614e4bf9bb0208a8b38
https://doi.org/10.1007/s10585-018-9876-z
https://doi.org/10.1007/s10585-018-9876-z
Publikováno v:
Journal of the American College of Surgeons. 233:S245
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2b8e27282d705945d278085640ae58
https://doi.org/10.1016/j.jamcollsurg.2021.07.507
https://doi.org/10.1016/j.jamcollsurg.2021.07.507