Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Justin G. Boyer"'
Autor:
Justin G. Boyer, Jiuzhou Huo, Sarah Han, Julian R. Havens, Vikram Prasad, Brian L. Lin, David A. Kass, Taejeong Song, Sakthivel Sadayappan, Ramzi J. Khairallah, Christopher W. Ward, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Boyer et al. created genetic mouse models of muscular dystrophy in which satellite cells were selectively depleted. The depletion of satellite cells at select times was protective. Myofibers no longer had plasma membrane instability leading to tissue
Externí odkaz:
https://doaj.org/article/05d4e5eb19ab42dd9227ed224828f09d
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ,
Externí odkaz:
https://doaj.org/article/ea6d8823af594410a638798be0e54bdd
Autor:
Justin G. Boyer, Jiuzhou Huo, Sarah Han, Julian R. Havens, Vikram Prasad, Brian L. Lin, David A. Kass, Taejeong Song, Sakthivel Sadayappan, Ramzi J. Khairallah, Christopher W. Ward, Jeffery D. Molkentin
Publikováno v:
Nature communications. 13(1)
Skeletal muscle can repair and regenerate due to resident stem cells known as satellite cells. The muscular dystrophies are progressive muscle wasting diseases underscored by chronic muscle damage that is continually repaired by satellite cell-driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e5278928b625329f9c6908298d784e
https://pubmed.ncbi.nlm.nih.gov/35618700
https://pubmed.ncbi.nlm.nih.gov/35618700
Publikováno v:
The Journal of Immunology. 208:165.14-165.14
Immune activation after tissue injury is required for removal of dead cells and debris to permit subsequent regenerative healing. Natural killer (NK) cells are innate lymphocytes that are essential for immune defense and for regulation of inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a84dc7f21df18aa4f2eafe3a8d6ea2ad
https://doi.org/10.4049/jimmunol.208.supp.165.14
https://doi.org/10.4049/jimmunol.208.supp.165.14
Autor:
Jeffery D. Molkentin, Justin G. Boyer, Onur Kanisicak, Jason Karch, Yi Zheng, Hadi Khalil, Bryan D. Maliken, Xing Fu, Vikram Prasad
Publikováno v:
Circulation. 138:1012-1024
Background: Although c-Kit + adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if these rare events represent true
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75605d1719c21adfc10a9deb2f89564d
https://doi.org/10.1161/circulationaha.118.033703
https://doi.org/10.1161/circulationaha.118.033703
Autor:
Onur Kanisicak, Burns C. Blaxall, Justin G. Boyer, Ronald J. Vagnozzi, Jeffery D. Molkentin, Hadi Khalil, Bryan D. Maliken, Xing Fu, Iñigo Valiente-Alandi, Vikram Prasad, Michelle A. Sargent
Publikováno v:
The Journal of Clinical Investigation
The identity and function of the fibroblast, a highly prevalent cell type in the heart, have remained poorly defined. Recent faithful genetic lineage–tracing studies revealed that during development, the cardiac fibroblasts are derived from the epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9263141f21c04673449a9c3a06b46199
http://europepmc.org/articles/PMC5957472
http://europepmc.org/articles/PMC5957472
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9465 (2010)
Dystonin is a giant cytoskeletal protein belonging to the plakin protein family and is believed to crosslink the major filament systems in contractile cells. Previous work has demonstrated skeletal muscle defects in dystonin-deficient dystonia muscul
Externí odkaz:
https://doaj.org/article/047b72059ba34a9ba337f4a997ee8100
Autor:
Justin G. Boyer, Jeffery D. Molkentin, Hadi Khalil, Sarah Han, Ronald J. Vagnozzi, Vikram Prasad
Satellite cells are skeletal muscle resident stem cells that regenerate adult myofibers following an acute injury to muscle. Despite the assumption that the loss of satellite cells would be detrimental in a chronic regeneration-inducing muscle diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73c11e935cee22ed4d2d0aa54cb2f43
Autor:
Hadi Khalil, Bryan D. Maliken, Ronald J. Vagnozzi, Jeffery D. Molkentin, Anne Katrine Z. Johansen, Vikram Prasad, Justin G. Boyer, Kunito Kawasaki, Robert N. Correll, Matthew J. Brody, Kazuhiro Nagata, Onur Kanisicak, Katja K. Kilian, Tobias G. Schips
Publikováno v:
JCI Insight
Collagen production in the adult heart is thought to be regulated by the fibroblast, although cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular chaperones are required for procollagen biosynthesis, including heat sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8bf71d129cb5da3acb83a5021115a7
https://doi.org/10.1172/jci.insight.128722
https://doi.org/10.1172/jci.insight.128722
Autor:
Sakthivel Sadayappan, Donghoon Lee, Vikram Prasad, Jeffery D. Molkentin, Michelle A. Sargent, Justin G. Boyer, Taejeong Song, Kelly M. Grimes, Xing Fu
Publikováno v:
JCI Insight
MAPK signaling consists of an array of successively acting kinases. ERK1 and -2 (ERK1/2) are major components of the greater MAPK cascade that transduce growth factor signaling at the cell membrane. Here, we investigated ERK1/2 signaling in skeletal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1909b567307833c5d8e31e9576fe9764
https://pubmed.ncbi.nlm.nih.gov/30964448
https://pubmed.ncbi.nlm.nih.gov/30964448