Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Justin G Lees"'
Autor:
Justin G Lees, Daniel White, Brooke A Keating, Mallory E Barkl-Luke, Preet G S Makker, David Goldstein, Gila Moalem-Taylor
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238164 (2020)
PurposeHaematological toxicities occur in patients receiving oxaliplatin. Mild anaemia (grade 1-2) is a common side effect and approximately 90% of recipients develop measurable spleen enlargement. Although generally asymptomatic, oxaliplatin-induced
Externí odkaz:
https://doaj.org/article/974eafa037e34cfeae0f803eb15d15f8
Autor:
Preet G S Makker, Samuel S Duffy, Justin G Lees, Chamini J Perera, Ryan S Tonkin, Oleg Butovsky, Susanna B Park, David Goldstein, Gila Moalem-Taylor
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170814 (2017)
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding of the mechanisms underpinning CIPN is limited and there are no effective treatment strategi
Externí odkaz:
https://doaj.org/article/4146e7d04e0c4cbeb6bc7e882504a81a
Autor:
Samuel Shaw Duffy, Chamini J Perera, Preet G S Makker, Justin G Lees, Pascal Carrive, Gila Moalem-Taylor
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Pain is a widespread and debilitating symptom of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. Although central neuroinflammation and demyelination have been implicated in MS-related pain, the co
Externí odkaz:
https://doaj.org/article/e2990b104e7b4ed8b682e4411dc38ec2
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Externí odkaz:
https://doaj.org/article/aa54e35e38344f3597b197c146885649
Autor:
Daniel White, Munawwar Abdulla, Susanna B. Park, David Goldstein, Gila Moalem‐Taylor, Justin G. Lees
Publikováno v:
Journal of the Peripheral Nervous System.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5320828c66fa4392ceea19c7b7aa52f6
https://doi.org/10.1111/jns.12544
https://doi.org/10.1111/jns.12544
Autor:
Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok
Publikováno v:
Journal of Translational Medicine. 20
Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-treated pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd49a42c96a6076530fac21f9ce8456e
https://doi.org/10.1186/s12967-022-03754-4
https://doi.org/10.1186/s12967-022-03754-4
Autor:
Susanna B. Park, David Goldstein, Nathan T Fiore, Justin G. Lees, Mallory E. Barkl-Luke, Lital Livni, Brooke A Keating, Munawwar Abdulla, Jessica P. Hayes, Gila Moalem-Taylor
Publikováno v:
Muscle & Nerve. 64:225-234
INTRODUCTION/AIMS Clinically, the chemotherapeutic agent oxaliplatin can cause peripheral neuropathy, impaired balance, and muscle wastage. Using a preclinical model, we investigated whether exercise intervention could improve these adverse condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27995d016c130f2ceface02bffc7a6e
https://doi.org/10.1002/mus.27329
https://doi.org/10.1002/mus.27329
Autor:
Preet G.S. Makker, James Howells, Justin G. Lees, Brooke A Keating, Gila Moalem-Taylor, David Burke
Publikováno v:
Journal of the Peripheral Nervous System. 26:99-112
Peripheral nerve injuries caused by focal constriction are characterised by local nerve ischaemia, axonal degeneration, demyelination, and neuroinflammation. The aim of this study was to understand temporal changes in the excitability properties of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e67a6c6957acb0ea055c75eeabbdac6
https://doi.org/10.1111/jns.12430
https://doi.org/10.1111/jns.12430
Autor:
Jasneet Parmar, James Howells, Daniel White, David Goldstein, Susanna B. Park, Justin G. Lees, Preet G.S. Makker, Gila Moalem-Taylor
Publikováno v:
Journal of Neurophysiology. 124:232-244
Oxaliplatin chemotherapy produces acute changes in peripheral nerve excitability in humans by modulating voltage-gated Na+ channel activity. However, there are few animal studies of oxaliplatin-induced neuropathy that demonstrate similar changes in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d69c7b8ad1442d3db325792933bf91
https://doi.org/10.1152/jn.00260.2020
https://doi.org/10.1152/jn.00260.2020
Autor:
Brooke A Keating, David Goldstein, Nathan T Fiore, Gila Moalem-Taylor, Justin G. Lees, Lital Livni
Publikováno v:
Pain. 163(1)
A modern approach for cancer treatment is the use of immunotherapy, and particularly immune checkpoint inhibitors, such as anti-programmed cell death protein 1 (PD-1), alone and in combination with chemotherapy. The PD-1 pathway plays a crucial role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8678551ae60ffd4db565b7fb50b8ad
https://pubmed.ncbi.nlm.nih.gov/34224494
https://pubmed.ncbi.nlm.nih.gov/34224494