Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Justin G Julander"'
Autor:
Kai Lin, Steven S Good, Justin G Julander, Abbie E Weight, Adel Moussa, Jean-Pierre Sommadossi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009937 (2022)
Yellow fever virus (YFV) is a zoonotic pathogen re-emerging in parts of the world, causing a viral hemorrhagic fever associated with high mortality rates. While an effective vaccine is available, having an effective antiviral against YFV is critical
Externí odkaz:
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777
Autor:
Dong-Hoon Chung, Colleen B Jonsson, Nichole A Tower, Yong-Kyu Chu, Ergin Sahin, Jennifer E Golden, James W Noah, Chad E Schroeder, Julie B Sotsky, Melinda I Sosa, Daniel E Cramer, Sara N McKellip, Lynn Rasmussen, E Lucile White, Connie S Schmaljohn, Justin G Julander, Jeffrey M Smith, Claire Marie Filone, John H Connor, Yasuteru Sakurai, Robert A Davey
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004213 (2014)
Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause encephalitis in humans and horses, but there are no therapeutics for treatment. To date, c
Externí odkaz:
https://doaj.org/article/18f656d9f91b4a0d9afd1e8d2f785905
Autor:
Jack T Nguyen, Donald F Smee, Dale L Barnard, Justin G Julander, Matthew Gross, Menno D de Jong, Gregory T Went
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e31006 (2012)
The limited efficacy of existing antiviral therapies for influenza--coupled with widespread baseline antiviral resistance--highlights the urgent need for more effective therapy. We describe a triple combination antiviral drug (TCAD) regimen composed
Externí odkaz:
https://doaj.org/article/3cc91cc5a81f4cc7b1837acc667920dd
Autor:
Steven B. Tillis, Camille Holt, Spencer Havens, Tracey D. Logan, Justin G. Julander, Robert J. Ossiboff
Publikováno v:
Microorganisms, Vol 11, Iss 6, p 1371 (2023)
Ophidian serpentoviruses, positive-sense RNA viruses in the order Nidovirales, are important infectious agents of both captive and free-ranging reptiles. Although the clinical significance of these viruses can be variable, some serpentoviruses are pa
Externí odkaz:
https://doaj.org/article/0b821025fa5e4aeea3219c2706d4f6be
Autor:
Michael P. Doyle, Joseph R. Genualdi, Adam L. Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M. Reeder, Christopher A. Nelson, Prashant N. Jethva, Rachel E. Sutton, Robin G. Bombardi, Michael L. Gross, Justin G. Julander, Daved H. Fremont, Michael S. Diamond, James E. Crowe
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Yellow fever virus (YFV) causes sporadic outbreaks of infection in South America and sub-Saharan Africa. While live-attenuated yellow fever virus vaccines based on three substrains of 17D are considered some of the most effective vaccines in
Externí odkaz:
https://doaj.org/article/db0fc1ff96ac4795a13221056ff7f496
Autor:
Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris
Publikováno v:
ACS Medicinal Chemistry Letters. 14:506-513
Autor:
Xufeng Cao, Dong Yang, Jyothi Parvathareddy, Yong-kyu Chu, Eun Jung Kim, Jhewelle N. Fitz-Henley, Xiaoyu Li, Pradeep B. Lukka, Keyur R. Parmar, Zaid H. Temrikar, Priya Dhole, Robert Scott Adcock, Jon Gabbard, Shruti Bansal, Jasper Lee, Lillian Zalduondo, Ernestine Hayes, Jennifer Stabenow, Bernd Meibohm, Elizabeth A. Fitzpatrick, Kevin Bailey, Rafael K. Campos, Justin G. Julander, Shannan L. Rossi, Donghoon Chung, Colleen B. Jonsson, Jennifer E. Golden
Publikováno v:
Science Translational Medicine. 15
Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV, respectively) are mosquito-borne, neuroinvasive human pathogens for which no FDA-approved therapeutic exists. Besides the biothreat posed by these viruses when aerosolized, arthropod
Autor:
Michael J. Ricciardi, Lauren N. Rust, Nuria Pedreño-Lopez, Sofiya Yusova, Sreya Biswas, Gabriela M. Webb, Lucas Gonzalez-Nieto, Thomas B. Voigt, Johan J. Louw, Fernanda D. Laurino, John R. DiBello, Hans-Peter Raué, Aaron M. Barber-Axthelm, Kimberly Chun, Samantha Uttke, Lidiane M. S. Raphael, Aaron Yrizarry-Medina, Brandon C. Rosen, Rebecca Agnor, Lina Gao, Caralyn Labriola, Michael Axthelm, Jeremy Smedley, Justin G. Julander, Myrna C. Bonaldo, Laura M. Walker, Ilhem Messaoudi, Mark K. Slifka, Dennis R. Burton, Esper G. Kallas, Jonah B. Sacha, David I. Watkins, Benjamin J. Burwitz
Publikováno v:
Science Translational Medicine. 15
Yellow fever virus (YFV) is a reemerging global health threat, driven by several factors, including increased spread of the mosquito vector and rapid urbanization. Although a prophylactic vaccine exists, vaccine hesitancy, supply deficits, and distri
Autor:
Lauren E. Williamson, Abhishek Bandyopadhyay, Kevin Bailey, Devika Sirohi, Thomas Klose, Justin G. Julander, Richard J. Kuhn, James E. Crowe
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Selection and development of monoclonal antibody (mAb) therapeutics against pathogenic viruses depends on certain functional characteristics. Neutralization potency, or the half-maximal inhibitory concentration (IC 50 ) values, is an important charac
Autor:
Justin G. Julander, Nicole Anderson, Nicole Haese, Takeshi Andoh, Daniel N. Streblow, Pierre Cortez, Kara Carter, Xavier Marniquet, Hugh Watson, Marie Mandron
Publikováno v:
Julander, J G, Anderson, N, Haese, N, Andoh, T, Streblow, D N, Cortez, P, Carter, K, Marniquet, X, Watson, H & Mandron, M 2022, ' Therapeutic and prophylactic treatment with a virus-specific antibody is highly effective in rodent models of Chikungunya infection and disease ', Antiviral Research, vol. 202, 105295 . https://doi.org/10.1016/j.antiviral.2022.105295
Chikungunya virus (CHIKV) has re-emerged as a significant human pathogen in the 21st century, causing periodic, and sometimes widespread, outbreaks over the past 15 years. Although mortality is very rare, a debilitating arthralgia is very common and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320928e2abfdf1282468f2088dc05295
https://pure.au.dk/portal/da/publications/therapeutic-and-prophylactic-treatment-with-a-virusspecific-antibody-is-highly-effective-in-rodent-models-of-chikungunya-infection-and-disease(909e6838-30fe-4244-81c9-234af39fc808).html
https://pure.au.dk/portal/da/publications/therapeutic-and-prophylactic-treatment-with-a-virusspecific-antibody-is-highly-effective-in-rodent-models-of-chikungunya-infection-and-disease(909e6838-30fe-4244-81c9-234af39fc808).html