Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Justin Eyquem"'
Autor:
Ian D. Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D. Posey, R. Dyche Mullins, Justin Eyquem, James A. Wells, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approac
Externí odkaz:
https://doaj.org/article/c60c92825695486592fb827ec64cf75c
Autor:
Zeguo Zhao, Mohamad Hamieh, Justin Eyquem, Michel Sadelain, Maria Sjöstrand, Jorge Mansilla-Soto, Sascha Haubner, Judith Feucht, Noémie Paillon, Andres Zucchetti, Zhuoning Li, Pieter Lindenbergh, Michelle Saetersmoen, Mathieu Maurin, Archana Iyer, Anton Dobrin, Andreina Garcia Angus, Matthew Miele, Theodoros Giavridis, Sjoukje van der Stegen, Fella Tamzalit, Morgan Huse, Ronald Hendrickson, Claire Hivroz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/595628448f684db780a076008ffd5232
Autor:
Yannick D. Muller, Duy P. Nguyen, Leonardo M. R. Ferreira, Patrick Ho, Caroline Raffin, Roxxana Valeria Beltran Valencia, Zion Congrave-Wilson, Theodore L. Roth, Justin Eyquem, Frederic Van Gool, Alexander Marson, Laurent Perez, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellula
Externí odkaz:
https://doaj.org/article/34363d2fe7bb42ecbbfa473401a411ce
Autor:
Dana V. Foss, Joseph J. Muldoon, David N. Nguyen, Daniel Carr, Srishti U. Sahu, John M. Hunsinger, Stacia K. Wyman, Netravathi Krishnappa, Rima Mendonsa, Elaine V. Schanzer, Brian R. Shy, Vivasvan S. Vykunta, Vincent Allain, Zhongmei Li, Alexander Marson, Justin Eyquem, Ross C. Wilson
Publikováno v:
Nature biomedical engineering, vol 7, iss 5
CRISPR-mediated genome editing of primary human lymphocytes is typically carried out via electroporation, which can be cytotoxic, cumbersome and costly. Here we show that the yields of edited primary human lymphocytes can be increased substantially b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d98d71ebdbd567262a88ba896fa4ca
https://escholarship.org/uc/item/0d8552gt
https://escholarship.org/uc/item/0d8552gt
Autor:
Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, Alexis Talbot, Theodore L. Roth, David N. Nguyen, Wolfgang G. Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R. Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G. Martin, Carlos E. Castro, Lumeng Ye, Jonathan H. Esensten, Justin Eyquem, Alexander Marson
Publikováno v:
Nat Biotechnol
Nature biotechnology, vol 41, iss 4
Nature biotechnology, vol 41, iss 4
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with Cas9 target sequences (CTSs) can be toxic to primary cells. Here, we develop single
Autor:
Sjoukje J. C. van der Stegen, Pieter L. Lindenbergh, Roseanna M. Petrovic, Hongyao Xie, Mame P. Diop, Vera Alexeeva, Yuzhe Shi, Jorge Mansilla-Soto, Mohamad Hamieh, Justin Eyquem, Annalisa Cabriolu, Xiuyan Wang, Ramzey Abujarour, Tom Lee, Raedun Clarke, Bahram Valamehr, Maria Themeli, Isabelle Riviere, Michel Sadelain
Publikováno v:
van der Stegen, S J C, Lindenbergh, P L, Petrovic, R M, Xie, H, Diop, M P, Alexeeva, V, Shi, Y, Mansilla-Soto, J, Hamieh, M, Eyquem, J, Cabriolu, A, Wang, X, Abujarour, R, Lee, T, Clarke, R, Valamehr, B, Themeli, M, Riviere, I & Sadelain, M 2022, ' Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells ', Nature Biomedical Engineering, vol. 6, no. 11, pp. 1284-1297 . https://doi.org/10.1038/s41551-022-00915-0
Nature Biomedical Engineering, 6(11), 1284-1297. Nature Publishing Group
Nat Biomed Eng
Nature Biomedical Engineering, 6(11), 1284-1297. Nature Publishing Group
Nat Biomed Eng
The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, costly and occasionally unsuccessful. T-cell-derived induced pluripotent stem cells (TiPS) are a promising source for the generation of ‘off-the-s
Autor:
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Zhongmei Li, Cody T. Mowery, William A. Nyberg, Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman, Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Eric Shifrut, Theodore L. Roth, Alexander Marson
Publikováno v:
Blood. 140:7404-7406
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Supplementary figure S1 : Gene disruption analysis in HEK293 cells. Supplementary figure S2: Optimization of the generation of double KO cells Supplementary table S1: Deep sequencing analysis of TCR-negative cells Supplementary figure S3: Representat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8a0d2010b9ea79650e3d9bcec08e56
https://doi.org/10.1158/0008-5472.22407593
https://doi.org/10.1158/0008-5472.22407593
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors (CAR) has emerged as a powerful means of treating cancer. However, a limitation of this approach is that autologous CAR T cells must be generated on a custom-made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e688c4450e87665a4af1443c9b0b0
https://doi.org/10.1158/0008-5472.c.6507341
https://doi.org/10.1158/0008-5472.c.6507341
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Supplementary Methods from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272179729b5359c94ee135c663060231
https://doi.org/10.1158/0008-5472.22407590
https://doi.org/10.1158/0008-5472.22407590