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of 9
pro vyhledávání: '"Justin E, LaVigne"'
Autor:
Tiffany S. Dwyer, Joseph B. O’Brien, Christopher P. Ptak, Justin E. LaVigne, Daniel P. Flaherty, Val J. Watts, David L. Roman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction
Externí odkaz:
https://doaj.org/article/4793afb3dd74437f826c2afee224beed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes. However this hypothesis is controversial, wit
Externí odkaz:
https://doaj.org/article/b6a8c60272aa4418b9b955283c91678f
Autor:
Justin E. LaVigne, Sascha R.A. Alles
Publikováno v:
Neurobiology of Pain, Vol 11, Iss , Pp 100092- (2022)
The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In th
Externí odkaz:
https://doaj.org/article/1951eac9bea74cb187c893689e7e95cb
Autor:
Jason A, Scott, Monica, Soto-Velasquez, Michael P, Hayes, Justin E, LaVigne, Heath R, Miller, Jatinder, Kaur, Karin F K, Ejendal, Val J, Watts, Daniel P, Flaherty
Publikováno v:
J Med Chem
Adenylyl cyclase type 1 (AC1) is involved in signaling for chronic pain sensitization in the central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a closely related isoform AC8 are also implicated to have roles i
Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Autor:
Jason A. Scott, Monica Soto-Velasquez, Michael P. Hayes, Justin E. LaVigne, Heath R. Miller, Jatinder Kaur, Karin F. K. Ejendal, Val J. Watts, Daniel P. Flaherty
Publikováno v:
Journal of Medicinal Chemistry. 65:4667-4686
Autor:
Justin E. LaVigne, Heath Miller, Karin F.K. Ejendal, Michael P. Hayes, Jason A. Scott, Val J. Watts, Monica Soto-Velasquez, Jatinder Kaur, Daniel P. Flaherty
Adenylyl cyclase type 1 is an emerging target for the treatment of chronic pain that is downstream on the analgesic pathway from the traditional µ-opioid receptor. AC1 is expressed in the central nervous system and critical for signaling in pain sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1461542fa846ed02e02940a4f6a8ea
https://doi.org/10.33774/chemrxiv-2021-h5hhv
https://doi.org/10.33774/chemrxiv-2021-h5hhv
Publikováno v:
The Journal of Pain. 23:27
Publikováno v:
The Journal of Pain. 23:10