Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Justin Demmerle"'
Autor:
Siyuan Hao, Ye Jin Lee, Nadav Benhamou Goldfajn, Eduardo Flores, Jindayi Liang, Hannah Fuehrer, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Cai
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109927- (2024)
Summary: YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular conden
Externí odkaz:
https://doaj.org/article/93e023ecedcf4265b02598fc8193056d
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTTranscription is the fundamental process of gene expression, which in eukaryotes occurs within the complex physicochemical environment of the nucleus. Decades of research have provided extreme detail in the molecular and functional mechanisms
Externí odkaz:
https://doaj.org/article/2167b470e5b84ec09e58b824644b6700
Autor:
Siyuan Hao, Hannah Fuehrer, Eduardo Flores, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Cai
SummaryYAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular condensa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f852e2ee3ae5a17539cc0656597ec5
https://doi.org/10.1101/2022.10.24.513621
https://doi.org/10.1101/2022.10.24.513621
Autor:
Carson J. Miller, Justin Demmerle, Gernot Wolf, Sherry Ralls, Ming-an Sun, Todd S. Macfarlan, Jiayao Jiang, Warren Wu
Motor neurons (MNs) control muscle movement and are essential for breathing, walking and fine motor skills. Motor Neuron and Pancreas Homeobox 1 (MNX1) has long been recognized as a key marker of the MN lineage. Deficiency of the Mnx1 gene in mice re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa6598a6df9d87818e8c15eec9b7aa7
https://doi.org/10.1101/2021.08.07.455331
https://doi.org/10.1101/2021.08.07.455331
Autor:
Justin Demmerle, Lothar Schermelleh, Tsotne Chitiashvili, Ezequiel Miron, Quentin Alle, Felix Kraus, Atsushi Matsuda, Alexei Budco, Heinrich Leonhardt, Yolanda Markaki
3D structured illumination microscopy (3D-SIM) is the super-resolution technique of choice for multicolor volumetric imaging. Here we provide a validated sample preparation protocol for labeling nuclei of cultured mammalian cells, image acquisition a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3507ee6599c24e6a95880b60d12af2f7
https://doi.org/10.1038/nprot.2017.020
https://doi.org/10.1038/nprot.2017.020
Autor:
Ezequiel Miron, Graeme Ball, Cassandravictoria Innocent, Lothar Schermelleh, Marcel Müller, Ian M. Dobbie, Justin Demmerle, Alison J. North, Atsushi Matsuda, Yolanda Markaki
Linear 2D- or 3D-structured illumination microscopy (SIM or 3D-SIM, respectively) enables multicolor volumetric imaging of fixed and live specimens with subdiffraction resolution in all spatial dimensions. However, the reliance of SIM on algorithmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac361545185939589b776c94a1735e4
https://ora.ox.ac.uk/objects/uuid:e52c55e0-8adc-4e5e-bb25-570110a499b1
https://ora.ox.ac.uk/objects/uuid:e52c55e0-8adc-4e5e-bb25-570110a499b1
Autor:
Justin Demmerle, Lothar Schermelleh
Publikováno v:
Translational Cancer Research. 5(S6)
Publikováno v:
Scientific Reports
Three-dimensional structured illumination microscopy (3D-SIM) is a versatile and accessible method for super-resolution fluorescence imaging, but generating high-quality data is challenging, particularly for non-specialist users. We present SIMcheck,
Publikováno v:
Methods (San Diego, Calif.). 88
Resolution is a central concept in all imaging fields, and particularly in optical microscopy, but it can be easily misinterpreted. The mathematical definition of optical resolution was codified by Abbe, and practically defined by the Rayleigh Criter
Autor:
Andrea, Cerase, Daniel, Smeets, Y Amy, Tang, Michal, Gdula, Felix, Kraus, Mikhail, Spivakov, Benoit, Moindrot, Marion, Leleu, Anna, Tattermusch, Justin, Demmerle, Tatyana B, Nesterova, Catherine, Green, Arie P, Otte, Lothar, Schermelleh, Neil, Brockdorff
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(6)
In female mammals, one of the two X chromosomes is transcriptionally silenced to equalize X-linked gene dosage relative to XY males, a process termed X chromosome inactivation. Mechanistically, this is thought to occur via directed recruitment of chr