Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Justin D. McCallen"'
Autor:
Yuta Myojin, Justin D. McCallen, Chi Ma, Kylynda C. Bauer, Benjamin Ruf, Mohamed-Reda Benmebarek, Benjamin L. Green, Simon Wabitsch, John C. McVey, Claude Fu, Changqing Xie, Tim F. Greten
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100959- (2024)
Backgrounds & Aims: The efficacy of immune checkpoint inhibitor (ICI) therapy for liver cancer remains limited. As the hypoxic liver environment regulates adenosine signaling, we tested the efficacy of adenosine A2a receptor (A2aR) inhibition in comb
Externí odkaz:
https://doaj.org/article/8a8b8d9041384815ac5be269a8423a00
Autor:
Mona A. Marie, Justin D. McCallen, Zahra S. Hamedi, Abdul Rafeh Naqash, Alexander Hoffman, Druid Atwell, Suneetha Amara, Mahvish Muzaffar, Paul R. Walker, Li V. Yang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immunotherapy has changed the paradigm of cancer treatment, yet immune checkpoint inhibitors (ICIs) such as PD-1/PD-L1 monoclonal antibodies may cause immune-related adverse events (irAEs) in some patients. In this report, two non-small cell lung can
Externí odkaz:
https://doaj.org/article/462c3431d46d4e318e45406f316f18aa
Autor:
Simon Wabitsch, Mayank Tandon, Benjamin Ruf, Qianfei Zhang, Justin D. McCallen, John C. McVey, Chi Ma, Benjamin L. Green, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1166-1178 (2021)
Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) accounts for a fraction of primary liver cancers but has a 5-year survival rate of only 10%. Immune checkpoint inhibitors are effective in treating many solid cancers, but immune checkpoint in
Externí odkaz:
https://doaj.org/article/7653432cbbe048aa9d6e9262cb8dbb33
Autor:
John C. McVey, Benjamin L. Green, Benjamin Ruf, Justin D. McCallen, Simon Wabitsch, Varun Subramanyam, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten, Chi Ma
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103847- (2022)
Summary: Non-alcoholic fatty liver disease (NAFLD) has become an important etiology leading to liver cancer. NAFLD alters adaptive T cell immunity and has a profound influence on liver cancer development. However, it is unclear how NAFLD affects tumo
Externí odkaz:
https://doaj.org/article/a5729820c7ea4f7fa2e4a3f196e9671e
Autor:
Melissa Y.Y. Moey, MD, MSc, Anna N. Tomdio, MD, Justin D. McCallen, BSc, Lauren M. Vaughan, MD, Kevin O’Brien, PhD, Abdul R. Naqash, MD, Cynthia Cherry, RN, ANP, Paul R. Walker, MD, Blase A. Carabello, MD
Publikováno v:
JACC. CardioOncology, Vol 2, Iss 3, Pp 491-502 (2020)
Background: Immune checkpoint inhibitor (ICI)-related cardiotoxicity (iRC) is uncommon but can be fatal. There have been few reports of iRC from a rural cancer population and few data for iRC and inflammatory biomarkers. Objectives: The purpose of th
Externí odkaz:
https://doaj.org/article/2691baca37014e2b929a2fc8add9b105
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100517- (2021)
Summary: Immunomodulatory drugs can alter lymphocyte function. Hydroxychloroquine (HCQ) is prescribed for many autoimmune diseases and is under investigation as an anti-tumor autophagy inhibitor. Here, we describe a protocol to evaluate the influence
Externí odkaz:
https://doaj.org/article/54a27c8e94314bb2bdad87710812b00e
Autor:
Abdul Rafeh Naqash, Ebenezer Appah, Li V. Yang, Mahvish Muzaffar, Mona A. Marie, Justin D. Mccallen, Shravanti Macherla, Darla Liles, Paul R. Walker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract Background Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed to be related to i
Externí odkaz:
https://doaj.org/article/8fb76ca2c40e4edd93e37771226ab1ae
Autor:
Li V. Yang, Karen A. Oppelt, Mary Jane Thomassen, Mona A. Marie, Shayan Nik Akhtar, Justin D. McCallen
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in late 2019 and has since rapidly become a global pandemic. SARS-CoV-2 infection causes damages to the lung and other organs. Th
Externí odkaz:
https://doaj.org/article/9ecb2fddef54487ab21e5c6e347bb894
Autor:
Simon Wabitsch, John C. McVey, Chi Ma, Benjamin Ruf, Olena Kamenyeva, Justin D. McCallen, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101990- (2021)
Summary: Hydroxychloroquine (HCQ) is a well-known anti-inflammatory drug but is also known as an anti-inflammatory drug. Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Anti-PD1 therapy-sensitive tumor
Externí odkaz:
https://doaj.org/article/d82811e1bbf545b393e42c4d2cd936b5
Autor:
Simon Wabitsch, Justin D. McCallen, Olena Kamenyeva, Benjamin Ruf, John C. McVey, Juraj Kabat, Juliane S. Walz, Yaron Rotman, Kylynda C. Bauer, Amanda J. Craig, Marie Pouzolles, Ira Phadke, Vanessa Catania, Benjamin L. Green, Claude Fu, Laurence P. Diggs, Bernd Heinrich, Xin Wei Wang, Chi Ma, Tim F. Greten
Publikováno v:
Journal of Hepatology. 77:748-760