Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Justin D, Vidal"'
Autor:
Michael S. Thibodeau, Manoj Bhaskaran, Aleksandra Zalewska, Balasubramanian Manickam, Justin D. Vidal, Jonathan Werner, Wendy G. Halpern, Karyn Colman, Sean McKeag, Benjamin Sefing, Darren Fegley, Karen S. Regan, Binod Jacob, Eveline de Rijk, Vimala Vemireddi, George A. Parker, Hitoshi Kandori
Publikováno v:
Toxicologic Pathology. 49:977-989
The sexual maturity status of animals in nonclinical safety studies can have a significant impact on the microscopic assessment of the reproductive system, the interpretation of potential test article–related findings, and ultimately the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b875dc51afa16eb8629752f0d10e9768
https://doi.org/10.1177/0192623321990631
https://doi.org/10.1177/0192623321990631
Autor:
Jochen Woicke, Muthafar M. Al-Haddawi, Jean-Guy Bienvenu, Jessica M. Caverly Rae, Franck J. Chanut, Karyn Colman, John M. Cullen, Wendell Davis, Ryo Fukuda, Maike Huisinga, Ursula Junker Walker, Kiyonori Kai, Ramesh C. Kovi, Nicholas P. Macri, Heike-Antje Marxfeld, Kristen J. Nikula, Ingrid D. Pardo, Thomas J. Rosol, Alok K. Sharma, Bhanu P. Singh, Kazutoshi Tamura, Michael S. Thibodeau, Enrico Vezzali, Justin D. Vidal, Emily K. Meseck
Publikováno v:
Toxicologic Pathology. 49:5-109
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative of the societies of toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6c7853ca62350eb8e995507fa8b2e2
https://doi.org/10.1177/0192623320968181
https://doi.org/10.1177/0192623320968181
Autor:
Peter Hall, Famke Aeffner, Vanessa L. Schumacher, Elizabeth Neyens, Elena Riccardi, Robert Klopfleisch, Laetitia Elies, Serge Rousselle, LuAnn McKinney, Daniel R Roth, Catherine Botteron, Xavier Palazzi, Heike A. Marxfeld, Justin D. Vidal, Thomas Lucotte, Bethany Jill Williams, Jeffery A Engelhardt, Pierluigi Fant, Thomas Forest, Erio Barale-Thomas, Jonathan Carter, Deon Hildebrand, Alain Piton, Pierre Moulin
Publikováno v:
Toxicologic Pathology. 49:720-737
With advancements in whole slide imaging technology and improved understanding of the features of pathologist workstations required for digital slide evaluation, many institutions are investigating broad digital pathology adoption. The benefits of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4bf2487a6b58d8bcd1bb5a7a28b901
https://doi.org/10.1177/0192623320975841
https://doi.org/10.1177/0192623320975841
Autor:
Justin D. Vidal, Manoj Bhaskaran, Mary Carsillo, Steve Denham, Olivia Dubay, Steven Laing, Balasubramanian Manickam, Stephanie Phillips, Jonathan Werner, Armando R. Irizarry Rovira
Publikováno v:
Toxicologic pathology. 50(5)
Sexually mature nonhuman primates are often used in nonclinical safety testing when evaluating biopharmaceuticals; however, there is limited information in historical control databases or in the published literature on the spontaneous findings in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d50d34930dbf3e65a934b50c93c78
https://pubmed.ncbi.nlm.nih.gov/35285336
https://pubmed.ncbi.nlm.nih.gov/35285336
Autor:
David R. Friend, Justin D. Vidal, Sarah Davis, Ginger D. Constantine, Philip R. Mayer, Bridget Martell, Herman Weiss, Doorbar Martin
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2677-2684
This study reports the preparation, in vitro release, pharmacokinetics, and local tolerability of novel ethylene-vinyl acetate intravaginal rings (IVRs) delivering 17β-estradiol (E2) and progesterone (P), in drug-naive ovariectomized female Dorset c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315ac612a186b78abd998c565d21cd00
https://doi.org/10.1016/j.xphs.2019.03.032
https://doi.org/10.1016/j.xphs.2019.03.032
Autor:
Sarah Davis, David R. Friend, Herman Weiss, Justin D. Vidal, Doorbar Martin, Philip R Mayer, Ginger D Constantine, Bridget Martell
Publikováno v:
Drug delivery and translational research. 9(5)
The objectives of this work were to evaluate the in vitro release and in vivo pharmacokinetics and local tolerability of a novel, segmented ethylene-vinyl acetate (EVA) intravaginal ring (IVR) delivering progesterone (P) in drug-naive ovariectomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa599b65fdfe49fbc34d7d5f9efad2
https://pubmed.ncbi.nlm.nih.gov/31066007
https://pubmed.ncbi.nlm.nih.gov/31066007
Autor:
Justin D. Vidal
Publikováno v:
Toxicologic Pathology for Non-Pathologists ISBN: 9781493997763
Test article–related effects on the reproductive system can have a profound effect on pharmaceutical development. The reproductive system has several unique features that differ from other organ systems, including complex hormonal regulation; age-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26578b93befd86d70ab817e4d51b6c03
https://doi.org/10.1007/978-1-4939-9777-0_11
https://doi.org/10.1007/978-1-4939-9777-0_11
Autor:
Justin D. Vidal
Publikováno v:
Toxicologic Pathology. 45:206-215
Evaluation of the female reproductive system in a general toxicity setting can be challenging for the toxicologic pathologist due to the cyclic nature of the estrous and menstrual cycles, timing of puberty and reproductive senescence, and species dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::040b050ed4ade35fd6a8a0e87779f5bc
https://doi.org/10.1177/0192623316673754
https://doi.org/10.1177/0192623316673754
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 104:244-252
Dabrafenib (DAB), an inhibitor of BRAF kinase activity, is approved for metastatic melanoma with a BRAF V600E mutation. In support of pediatric cancer development, a nonclinical juvenile rat toxicity study was conducted in which females had early vag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7e4dcf91b66665c8b704d8e9e0b93c
https://doi.org/10.1002/bdrb.21165
https://doi.org/10.1002/bdrb.21165
Publikováno v:
Toxicologic Pathology ISBN: 9780429504624
This chapter provides more information on normal anatomy, histology, physiology, and endocrinology of Reproductive System and Mammary Gland. Compound-related effects on the reproductive system can be pivotal in pharmaceutical development. It consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bec2deecffda9ee990057b353b59d6d
https://doi.org/10.1201/9780429504624-20
https://doi.org/10.1201/9780429504624-20