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pro vyhledávání: '"Justin D, Middleton"'
Autor:
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Dendritic cells (DC) present tumour antigens to T cells but this process is defective in the tumour microenvironment. Here the authors find that downregulation of cholesterol 25-hydroxylase underlies defective cross presentation of tumour antigens.
Externí odkaz:
https://doaj.org/article/6f99c246674341cbadfcbbf971df3ad6
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10280 (2021)
Previously, we showed that mice treated with cyclophosphamide (CTX) 4 days before intravenous injection of breast cancer cells had more cancer cells in the lung at 3 h after cancer injection than control counterparts without CTX. At 4 days after its
Externí odkaz:
https://doaj.org/article/6798df170420483cbe60d6ec714cf79c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7356 (2021)
Previously, we showed that chemotherapy paradoxically exacerbated cancer cell colonization at the secondary site in a manner dependent on Atf3, a stress-inducible gene, in the non-cancer host cells. Here, we present evidence that this phenotype is es
Externí odkaz:
https://doaj.org/article/dce1f2bece1c4d9b988fcd5a6cc5b6a5
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3333 (2018)
An emerging picture in cancer biology is that, paradoxically, chemotherapy can actively induce changes that favor cancer progression. These pro-cancer changes can be either inside (intrinsic) or outside (extrinsic) the cancer cells. In this review, w
Externí odkaz:
https://doaj.org/article/5abbe877dc844e88973b5e473be035e8
Autor:
Justin D, Middleton, Jared, Fehlman, Subhakeertana, Sivakumar, Daniel G, Stover, Tsonwin, Hai
Publikováno v:
International Journal of Molecular Sciences
Previously, we showed that chemotherapy paradoxically exacerbated cancer cell colonization at the secondary site in a manner dependent on Atf3, a stress-inducible gene, in the non-cancer host cells. Here, we present evidence that this phenotype is es
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(34)
Chemotherapy is a double-edged sword. It is anticancer because of its cytotoxicity. Paradoxically, by increasing chemoresistance and cancer metastasis, it is also procancer. However, the underlying mechanisms for chemotherapy-induced procancer activi