Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Justin Caserta"'
Autor:
Christopher E. Katz, Bingidimi I. Mobele, Jalal Haddad, Yusuke Yamai, Kazuki Hashimoto, Yujiro Kiyoshima, Justin Caserta
Publikováno v:
Organic Process Research & Development.
Autor:
Eriko, Katsuta, Malgorzata, Gil-Moore, Justine, Moore, Mohamed, Yousif, Alex A, Adjei, Yi, Ding, Justin, Caserta, Carmen M, Baldino, Kelvin P, Lee, Irwin H, Gelman, Kazuaki, Takabe, Mateusz, Opyrchal
Publikováno v:
International Journal of Oncology. 61
Proviral integration of Moloney virus 2 (PIM2) is a pro‑survival factor of cancer cells and a possible therapeutic target in hematological malignancies. However, the attempts at inhibiting PIM2 have yielded underwhelming results in early clinical t
Autor:
Gerald J. Fetterly, K Bezbatchenko, Mateusz Opyrchal, Kelvin P. Lee, R Mehta, Carmen M. Baldino, Justin Caserta, Malgorzata Gil, D Kothai Guruswamy Sangameswaran, A. A. Adjei, J Moore, Thaer Khoury
Publikováno v:
Cancer Research. 77:P6-11
Background: Triple negative breast cancer (TNBC) patients have poorer prognosis and there remains a lack of novel targeted therapies for their treatment. PIM2 (Proviral Integrations of Moloney virus 2) belongs to a family of three kinases that have b
Autor:
Robb Nicewonger, Michael Baldino, Stephane Dumas, Chee-Seng Lee, Carmen M. Baldino, Justin Caserta, Yvonne Flanders
Publikováno v:
Tetrahedron Letters. 56:3186-3190
Herein, we describe the versatile synthesis of (Z)-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors (1) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the g
Autor:
Gerald J. Fetterly, K Belko, T Howell, Kelvin P. Lee, Carmen M. Baldino, Jayakumar R. Nair, Justin Caserta
Publikováno v:
Leukemia
The PIM kinase family (PIM1, 2 and 3) have a central role in integrating growth and survival signals, and are expressed in a wide range of solid and hematological malignancies. We now confirm that PIM2 is overexpressed in multiple myeloma (MM) patien
ChemInform Abstract: A Versatile Synthesis of Novel pan-PIM Kinase Inhibitors with Initial SAR Study
Autor:
Michael Baldino, Robb Nicewonger, Chee-Seng Lee, Carmen M. Baldino, Yvonne Flanders, Justin Caserta, Stephane Dumas
Publikováno v:
ChemInform. 46
Herein, we describe the versatile synthesis of (Z)-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors (1) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the g
Autor:
Krista E. Pundt, Camern Baldino, Gerald J. Fetterly, Alex A. Adjei, Laura Pitzonka, Verone-Boyle Alissa Rae, Kelvin P. Lee, Xu Zhu, Frank Engler, Justin Caserta
Publikováno v:
Cancer Research. 76:4824-4824
Standard therapy for acute myeloid leukemia (AML) results in significant mortality and morbidity with an overall cure rate of only 25%. Implementation of novel therapeutic options is needed in order to significantly improve patient survival and outco
Autor:
Wei Luo, Carmen M. Baldino, Candace S. Johnson, Pili Roberto, Swathi Ramakrishnan, Yingyu Ma, Justin Caserta, Donald L. Trump
Publikováno v:
Cancer Research. 75:5056-5056
Dysregulation of vitamin D signaling and metabolism enzymes is a frequent change in many cancers and may confound approaches to vitamin -D based therapies. The mechanisms by which aberrant vitamin D signaling and metabolism lead to resistance to vita
Autor:
Carmen M. Baldino, Laura Pitzonka, Krista E. Pundt, Alex A. Adjei, Kelvin P. Lee, Gerald J. Fetterly, Justin Caserta
Publikováno v:
Cancer Research. 75:681-681
Leukemia, an aggressive immature hematological malignancy, is the sixth leading cause of cancer death in the U.S., with an overall cure rate of only 25%. PIM kinases are serine/threonine kinases that regulate cell cycle and survival. In hematological
Publikováno v:
The Journal of Immunology. 194:211.32-211.32
Plasma cells (PC) depend on interactions with bone marrow stroma and the resultant growth factors for their long lived survival. Very little is known about the molecular mediators of these survival signals. One such molecule that has recently come of