Výsledky vyhledávání - "Justin C. Paglino"

Autonomous Parvoviruses neither Stimulate nor Are Inhibited by the Type I Interferon Response in Human Normal or Cancer Cells

Autor: Wells Andres, Anthony N. van den Pol, Justin C. Paglino

Publikováno v: Journal of Virology. 88:4932-4942

Members of the genus Parvovirus are small, nonenveloped single-stranded DNA viruses that are nonpathogenic in humans but have potential utility as cancer therapeutics. Because the innate immune response to parvoviruses has received relatively little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d46f509573086e102c22a516e1e22c
https://doi.org/10.1128/jvi.03508-13

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LuIII Parvovirus Selectively and Efficiently Targets, Replicates in, and Kills Human Glioma Cells

Autor: Justin C. Paglino, Anthony N. van den Pol, Koray Özduman

Publikováno v: Journal of Virology. 86:7280-7291

Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ab79a8c16daac8cb8b759333ecf550
https://doi.org/10.1128/jvi.00227-12

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Exploring the contribution of distal P4 promoter elements to the oncoselectivity of Minute Virus of Mice

Autor: Justin C. Paglino, Erik Burnett, Peter Tattersall

Publikováno v: Virology. 361(1):174-184

Minute Virus of Mice (MVM) shares inherent oncotropic properties with other members of the genus Parvovirus. Two elements responsible, at least in part, for this oncoselectivity have been mapped to an Ets1 binding site adjacent to the P4 TATA box of

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Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector

Autor: Patrick R. Maloney, Justin C. Paglino, Guido Wollmann, Anthony N. van den Pol, Sebastian A. Ahmadi

Vesicular stomatitis virus (VSV) shows promise as a vaccine-vector and oncolytic virus. However, reports of neurotoxicity of VSV remain a concern. We compared 12 antiviral compounds to control infection of VSV-CT9-M51 and VSV-rp30 using murine and hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2c4ea18a2ae767a3e4bbb3d8d75708
https://europepmc.org/articles/PMC4326005/

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Vesicular stomatitis virus has extensive oncolytic activity against human sarcomas: rare resistance is overcome by blocking interferon pathways

Autor: Justin C. Paglino, Anthony N. van den Pol

Publikováno v: Journal of virology. 85(18)

Oncolytic viruses have been tested against many carcinomas of ectodermal and endodermal origin; however, sarcomas, arising from mesoderm, have received relatively little attention. Using 13 human sarcomas representing seven tumor types, we assessed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb49d88e42e1b802017c4189e5ab65c
https://pubmed.ncbi.nlm.nih.gov/21734048

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The parvoviral capsid controls an intracellular phase of infection essential for efficient killing of stepwise-transformed human fibroblasts

Autor: Peter Tattersall, Justin C. Paglino

Publikováno v: Virology. (1-2):32-41

Members of the rodent subgroup of the genus Parvovirus exhibit lytic replication and spread in many human tumor cells and are therefore attractive candidates for oncolytic virotherapy. However, the significant variation in tumor tropism observed for

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