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pro vyhledávání: '"Justin C. Miller"'
Autor:
Justin C. Miller, Joel H. Z. Lee, Mark A. Mclean, Rebecca R. Chao, Isobella S. J. Stone, Tara L. Pukala, John B. Bruning, James J. De Voss, Mary A. Schuler, Stephen G. Sligar, Stephen G. Bell
Publikováno v:
Journal of the American Chemical Society. 145:9207-9222
Autor:
Justin C. Miller, Mary A. Schuler
Publikováno v:
Journal of Biological Chemistry. 298:102237
Terpene indole alkaloids (TIAs) are plant-derived specialized metabolites with widespread use in medicine. Species-specific pathways derive various TIAs from common intermediates, strictosidine or strictosidinic acid, produced by coupling tryptamine
Publikováno v:
Phytochemistry. 183
Divergent terpene indole alkaloid (TIA) pathways in Catharanthus roseus and Camptotheca acuminata generate vinblastine and vincristine, and camptothecin, respectively. In contrast to Catharanthus which feeds secologanin (from methylated loganin) into