Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Justin C. Jones"'
Autor:
Tammy M. Barnes, Kimi Shah, Margaret B. Allison, Gabrielle K. Steinl, Desiree Gordian, Paul V. Sabatini, Abigail J. Tomlinson, Wenwen Cheng, Justin C. Jones, Qing Zhu, Chelsea Faber, Martin G. Myers, Jr.
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 168-175 (2020)
Background: Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet-unide
Externí odkaz:
https://doaj.org/article/5014c4454bcb434e8bdd4c9611f5b50a
Autor:
Warren Pan, Margaret B. Allison, Paul Sabatini, Alan Rupp, Jessica Adams, Christa Patterson, Justin C. Jones, David P. Olson, Martin G. Myers, Jr.
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 121-131 (2019)
Objectives: Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and ST
Externí odkaz:
https://doaj.org/article/5105075d338248cf9047b19dad89f22e
Autor:
Alan C. Rupp, Margaret B. Allison, Justin C. Jones, Christa M. Patterson, Chelsea L. Faber, Nadejda Bozadjieva, Lora K. Heisler, Randy J. Seeley, David P. Olson, Martin G. Myers, Jr.
Publikováno v:
Molecular Metabolism, Vol 14, Iss , Pp 130-138 (2018)
Objective: To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC) Pomc- or Agrp-expressing cells) has only minimally affected energy balance. In
Externí odkaz:
https://doaj.org/article/c98d701724a746e98f6e1b6ad33a19ac
Autor:
Chelsea L. Faber, Tammy M. Barnes, Martin G. Myers, Wenwen Cheng, Margaret B. Allison, Gabrielle K. Steinl, Justin C. Jones, Kimi Shah, Desiree Gordian, Abigail J Tomlinson, Paul V. Sabatini, Qing Zhu
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 168-175 (2020)
Molecular Metabolism, Vol 32, Iss, Pp 168-175 (2020)
Background Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet-uniden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6530853594b0b30fe7c1b9c7b747b3ca
http://europepmc.org/articles/PMC6992902
http://europepmc.org/articles/PMC6992902
Autor:
Garth W. Strohbehn, Christa M. Patterson, Jessica M. Adams, David P. Olson, Martin G. Myers, James L. Trevaskis, Justin C. Jones, Jonathan N. Flak, Christopher J. Rhodes, Margaret B. Allison, Warren Pan
Publikováno v:
Endocrinology. 159:1860-1872
The adipocyte-derived hormone leptin acts via its receptor (LepRb) on central nervous system neurons to communicate the repletion of long-term energy stores, to decrease food intake, and to promote energy expenditure. We generated mice that express C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fdd6a0b6dd9e4b14adf4d755e0d3f4
https://doi.org/10.1210/en.2017-03259
https://doi.org/10.1210/en.2017-03259
Autor:
Christa M. Patterson, Gina M. Leinninger, Margaret B. Allison, Jenny Marie T. Wong, Robert T. Kennedy, Justin C. Jones, Omar S. Mabrouk, Alexander MacKenzie, Chelsea Kasper, Ian E. Gonzalez, Martin G. Myers
Publikováno v:
Endocrinology. 156:1692-1700
Projections from the lateral hypothalamic area (LHA) innervate components of the mesolimbic dopamine (MLDA) system, including the ventral tegmental area (VTA) and nucleus accumbens (NAc), to modulate motivation appropriately for physiologic state. Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b0df16a197134c1552c7c1c7dcbc31
https://doi.org/10.1210/en.2014-1986
https://doi.org/10.1210/en.2014-1986
Autor:
Christa M. Patterson, Robert T. Kennedy, Martin G. Myers, Christopher J. Rhodes, Paulette B. Goforth, Amy K. Sutton, Paige A. Malec, Mark Germani, Jenny Marie T. Wong, Giuseppe D'Agostino, Jonathan N. Flak, Justin C. Jones, David P. Olson, Leslie S. Satin, Lora K. Heisler, Michael Rajala, Alastair S. Garfield
Publikováno v:
Nature Neuroscience. 17:1744-1750
Hypoglycemia initiates the counter-regulatory response (CRR), in which the sympathetic nervous system, glucagon and glucocorticoids restore glucose to appropriate concentrations. During starvation, low leptin levels restrain energy utilization, enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c000e1d325129eca8f72675aefcbb6
https://doi.org/10.1038/nn.3861
https://doi.org/10.1038/nn.3861
Autor:
Martin G. Myers, Natinder Saini, Megan Greenwald-Yarnell, Christa M. Patterson, Eneida C. Villanueva, Ian E. Gonzalez, Justin C. Jones, Michael Rajala
Publikováno v:
Molecular Metabolism. 1:61-69
Leptin action in the brain signals the repletion of adipose energy stores, suppressing feeding and permitting energy expenditure on a variety of processes, including reproduction. Leptin binding to its receptor (LepR-b) promotes the tyrosine phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a8f113834b2df487487b0527af91ca
https://doi.org/10.1016/j.molmet.2012.05.001
https://doi.org/10.1016/j.molmet.2012.05.001
Publikováno v:
Brain Research. 1378:18-28
Leptin acts via the long form of the leptin receptor (LepRb) on specialized sets of neurons in the brain to modulate diverse functions in concert with energy stores. Previous studies have revealed the distribution of LepRb-expressing neurons in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3fcf2b651dbaed3acd68be7682a674
https://doi.org/10.1016/j.brainres.2011.01.010
https://doi.org/10.1016/j.brainres.2011.01.010
Autor:
Ryoko Ishida-Takahashi, Justin C. Jones, Scott Robertson, Christa M. Patterson, Rohit N. Kulkarni, Martin G. Myers, Isao Tawara, Jiang Hu
Publikováno v:
Diabetes
OBJECTIVE Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes the phosphorylation of tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b45600bab6ff66b7c3a54baf679596
http://europepmc.org/articles/PMC2844825
http://europepmc.org/articles/PMC2844825