Výsledky vyhledávání - "Justin C. Bader"

Selinexor population pharmacokinetic and exposure–response analyses to support dose optimization in patients with diffuse large B-cell lymphoma

Autor: Hanbin Li, Russ Wada, Justin C Bader, Sharon Shacham, Shijie Tang, Jatin P. Shah, Hongmei Xu

Publikováno v: Cancer Chemotherapy and Pharmacology. 88:69-79

Characterize the population PK and exposure–response (ER) relationships of selinexor in patients with diffuse large B-cell lymphoma (DLBCL) (efficacy endpoints) or other non-Hodgkin’s lymphoma (NHL) patients (safety endpoints) to determine the op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f32c729612b52d50c7f354dede5ced
https://doi.org/10.1007/s00280-021-04258-6

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Pharmacokinetics of Selinexor: The First-in-Class Selective Inhibitor of Nuclear Export

Autor: Albiruni Ryan Abdul Razak, Hongmei Xu, Sharon Shacham, Justin C Bader

Publikováno v: Clinical pharmacokinetics. 60(8)

The functionality of many tumor suppressor proteins (TSPs) and oncoprotein transcript RNAs largely depend on their location within the cell. The exportin 1 complex (XPO1) transports many of these molecules from the nucleus into the cytoplasm, thereby

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ef43425c951a11589d4bfc85ab1d31
https://pubmed.ncbi.nlm.nih.gov/33928519

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Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia

Autor: Elizabeth A Lakota, Helio S. Sader, Paul G. Ambrose, Justin C Bader, Sujata M. Bhavnani, John H. Rex, Glenn E. Dale

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Ertapenem provides activity against many pathogens commonly associated with hospital-acquired and ventilator-associated bacterial pneumoniae (HABP and VABP, respectively), including methicillin-susceptible Staphylococcus aureus and numerous Gram-nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890b9160d67593e13dcce445eabbed4b
https://doi.org/10.1128/aac.00318-19

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Pharmacokinetic/pharmacodynamic target attainment analyses to support intravenous and oral lefamulin dose selection for the treatment of patients with community-acquired bacterial pneumonia

Autor: Sujata M. Bhavnani, Christopher M. Rubino, Steven P Gelone, Li Zhang, Paul G. Ambrose, Helio S. Sader, Wolfgang W Wicha, Jeffrey P. Hammel, Justin C Bader

Publikováno v: Journal of Antimicrobial Chemotherapy

Objectives Lefamulin is a semi-synthetic intravenous (iv) and oral pleuromutilin antibiotic active against community-acquired bacterial pneumonia (CABP) pathogens. Pharmacokinetic/pharmacodynamic (PK/PD) target attainment analyses were carried out to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38ed96dd11bab69bc916cf121457543
https://pubmed.ncbi.nlm.nih.gov/30949705

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Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae

Autor: Paul G. Ambrose, Yanli Wang, Ping Wang, Miao Zhao, Qingmei Liu, David R. Andes, Justin C Bader, Alexander J. Lepak

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

KBP-7072 is a novel aminomethylcycline antibiotic in clinical development for community-acquired pneumonia. The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9222ace91983f77342afc6b3998842ef
https://doi.org/10.1128/aac.02404-18

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Overcoming the Resistance Hurdle: Pharmacokinetic-Pharmacodynamic Target Attainment Analyses for Rezafungin (CD101) against Candida albicans and Candida glabrata

Autor: Christopher M. Rubino, Paul G. Ambrose, Voon Ong, Taylor Sandison, Shawn Flanagan, Justin C Bader, Sujata M. Bhavnani, Elizabeth A Lakota

Publikováno v: Antimicrobial Agents and Chemotherapy

Rezafungin (CD101) is a novel echinocandin antifungal agent with activity against Aspergillus and Candida species, including azole- and echinocandin-resistant isolates. The objective of these analyses was to conduct pharmacokinetic (PK)-pharmacodynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7931db73bf3a23c74d6bb1e6c0596977
http://europepmc.org/articles/PMC5971579

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Norepinephrine in Combination with Antibiotic Therapy Increases both the Bacterial Replication Rate and Bactericidal Activity

Autor: Brian VanScoy, Paul G. Ambrose, John H. Adams, Christopher M. Rubino, Steven Fikes, Justin C Bader, Sujata M. Bhavnani

We previously demonstrated that the rate and extent of an antimicrobial agent's bactericidal effects were coupled to the bacterial replication rate, the latter of which was modulated with the sodium chloride concentration. Herein, we describe the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca388d7f19f6ae8c0c038598dc26568
https://europepmc.org/articles/PMC5914008/

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In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model

Autor: Paul G. Ambrose, Justin C Bader, David R. Andes, Karen Marchillo, Brian VanScoy, Alexander J. Lepak, Jamie VanHecker, Miao Zhao

APX001 is the prodrug of APX001A, which is a first-in-class small molecule with a unique mechanism of action that inhibits the fungal enzyme Gwt1 in the glycosylphosphatidylinositol (GPI) biosynthesis pathway. The goal of the present study was to det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da1a7dfcf4f45f226fefd873930df5f
https://europepmc.org/articles/PMC5913987/

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Correction to: PK-PD Compass: bringing infectious diseases pharmacometrics to the patient's bedside

Autor: Li Zhang, Paul G. Ambrose, Scott A. Van Wart, Christopher M. Rubino, Sujata M. Bhavnani, Justin C Bader, Kim L Sweeney, Catharine C. Bulik

Publikováno v: Journal of pharmacokinetics and pharmacodynamics. 45(2)

The original version of this article contained incorrect Supplementary Files. The correct Supplementary Files are published with this erratum.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cad15055ad644ba430382baef803c7
https://pubmed.ncbi.nlm.nih.gov/28353185

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