Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Justin C St John"'
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1477 (2024)
Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation. Brain, liver and heart
Externí odkaz:
https://doaj.org/article/aa4ef23b6b5744239aa445a721e115c0
Autor:
Yan Jiang, Richard Kelly, Amy Peters, Helena Fulka, Adam Dickinson, Daniel A Mitchell, Justin C St John
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14805 (2011)
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another. Once activated, reconstructed oocytes can be cultured in vitro to blastocyst, the
Externí odkaz:
https://doaj.org/article/ac1b8474e5d94e9ea6b59028ac48ec24
Autor:
L Gabriel Sanchez-Partida, Richard D W Kelly, Huseyin Sumer, Camden Y Lo, Rotem Aharon, Michael K Holland, Moira K O'Bryan, Justin C St John
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21597 (2011)
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic
Externí odkaz:
https://doaj.org/article/2eb12464c9fd4091865299154903cc33
Autor:
Takashi Okada, Stephen McIlfatrick, Nhi Hin, Nader Aryamanesh, James Breen, Justin C. St. John
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract Background Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA through mitochondrial supplementation of mtDNA-deficient Sus scrofa oocytes
Externí odkaz:
https://doaj.org/article/3ee773e8f5a14c7595f2ee50dc70d239
Autor:
Stephen McIlfatrick, Sean O’Leary, Takashi Okada, Alexander Penn, Vy Hoang Thao Nguyen, Lisa McKenny, Shang-Yu Huang, Eryk Andreas, John Finnie, Roy Kirkwood, Justin C. St. John
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105956- (2023)
Summary: Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor quality oocytes. However, supplementation alters DNA methylation and gene expression profiles of preimplantation embryos. To determine if these alterat
Externí odkaz:
https://doaj.org/article/7b6448c8647746d19f6f8e96be21b5f6
Autor:
Rafiatu Azumah, Katja Hummitzsch, Monica D. Hartanti, Justin C. St. John, Richard A. Anderson, Raymond J. Rodgers
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Polycystic Ovary Syndrome (PCOS) is a multifactorial syndrome with reproductive, endocrine, and metabolic symptoms, affecting about 10% women of reproductive age. Pathogenesis of the syndrome is poorly understood with genetic and fetal origins being
Externí odkaz:
https://doaj.org/article/bf592aeb2aa342d192d0668fa782a4e8
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) modulates the nuclear genome. To eliminate any confounding effects fr
Externí odkaz:
https://doaj.org/article/f99bbffe66ee47ad8b41b6cdbcd0fe35
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 7, Pp 2065-2080 (2017)
The mixing of mitochondrial DNA (mtDNA) from the donor cell and the recipient oocyte in embryos and offspring derived from somatic cell nuclear transfer (SCNT) compromises genetic integrity and affects embryo development. We set out to generate SCNT
Externí odkaz:
https://doaj.org/article/bcedd036b3054805960710383c9562ea
Publikováno v:
Molecular reproduction and developmentREFERENCES.
The mitochondrial genome resides in the mitochondria present in nearly all cell types. The porcine (Sus scrofa) mitochondrial genome is circa 16.7 kb in size and exists in the multimeric format in cells. Individual cell types have different numbers o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935920123357faa46b32df014463224
https://pubmed.ncbi.nlm.nih.gov/35986715
https://pubmed.ncbi.nlm.nih.gov/35986715
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7545
Oocytes can be supplemented with extra copies of mitochondrial DNA (mtDNA) to enhance developmental outcome. Pigs generated through supplementation with mtDNA derived from either sister (autologous) or third-party (heterologous) oocytes have been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d32d438c1c7573dd6b2fd66a42cb92
https://doi.org/10.3390/ijms24087545
https://doi.org/10.3390/ijms24087545