Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Justin C, St John"'
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1477 (2024)
Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation. Brain, liver and heart
Externí odkaz:
https://doaj.org/article/aa4ef23b6b5744239aa445a721e115c0
Autor:
Takashi Okada, Stephen McIlfatrick, Nhi Hin, Nader Aryamanesh, James Breen, Justin C. St. John
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract Background Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA through mitochondrial supplementation of mtDNA-deficient Sus scrofa oocytes
Externí odkaz:
https://doaj.org/article/3ee773e8f5a14c7595f2ee50dc70d239
Autor:
Stephen McIlfatrick, Sean O’Leary, Takashi Okada, Alexander Penn, Vy Hoang Thao Nguyen, Lisa McKenny, Shang-Yu Huang, Eryk Andreas, John Finnie, Roy Kirkwood, Justin C. St. John
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105956- (2023)
Summary: Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor quality oocytes. However, supplementation alters DNA methylation and gene expression profiles of preimplantation embryos. To determine if these alterat
Externí odkaz:
https://doaj.org/article/7b6448c8647746d19f6f8e96be21b5f6
Autor:
Rafiatu Azumah, Katja Hummitzsch, Monica D. Hartanti, Justin C. St. John, Richard A. Anderson, Raymond J. Rodgers
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Polycystic Ovary Syndrome (PCOS) is a multifactorial syndrome with reproductive, endocrine, and metabolic symptoms, affecting about 10% women of reproductive age. Pathogenesis of the syndrome is poorly understood with genetic and fetal origins being
Externí odkaz:
https://doaj.org/article/bf592aeb2aa342d192d0668fa782a4e8
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)
Abstract Background Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differenti
Externí odkaz:
https://doaj.org/article/7a31a962090b498ba018dfcf9199bf78
Autor:
Xin Sun, Justin C. St John
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-18 (2018)
Abstract Background There are multiple copies of mitochondrial DNA (mtDNA) present in each cell type, and they are strictly regulated in a cell-specific manner by a group of nuclear-encoded mtDNA-specific replication factors. This strict regulation o
Externí odkaz:
https://doaj.org/article/01301ea5146b4c6994807eff10255788
Autor:
Justin C. St. John, Te-Sha Tsai
Publikováno v:
BMC Genetics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background The mitochondrial genome (mtDNA) is an emerging determiner of phenotypic traits and disease. mtDNA is inherited in a strict maternal fashion from the population of mitochondria present in the egg at fertilisation. Individuals are
Externí odkaz:
https://doaj.org/article/676b0062770a4f25b83e404f479f0064
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) modulates the nuclear genome. To eliminate any confounding effects fr
Externí odkaz:
https://doaj.org/article/f99bbffe66ee47ad8b41b6cdbcd0fe35
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 7, Pp 2065-2080 (2017)
The mixing of mitochondrial DNA (mtDNA) from the donor cell and the recipient oocyte in embryos and offspring derived from somatic cell nuclear transfer (SCNT) compromises genetic integrity and affects embryo development. We set out to generate SCNT
Externí odkaz:
https://doaj.org/article/bcedd036b3054805960710383c9562ea
Publikováno v:
BMC Genetics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Cattle are bred for, amongst other factors, specific traits, including parasite resistance and adaptation to climate. However, the influence and inheritance of mitochondrial DNA (mtDNA) are not usually considered in breeding progr
Externí odkaz:
https://doaj.org/article/d869f2c5e26b4af7a8d915a58ffec23a