Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Justin B. Jones"'
Autor:
W. David Wilson, Peter B. Uthe, Justin B. Jones, Alan Sielaff, Moses Lee, Caroline O'Hare, Laura M. Westrate, Jerome Kluza, James P. Lajiness, Binh Nguyen, Toni Brown, Zach Davis, Hilary Mackay, Chrystal D. Bruce, John A. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9145-9153
Imidazole (Im) and Pyrrole (Py)-containing polyamides that can form stacked dimers can be programmed to target specific sequences in the minor groove of DNA and control gene expression. Even though various designs of polyamides have been thoroughly i
Autor:
Jim S. Sexton, Keith Mulder, Peter B. Uthe, Zarmeen T. Taherbhai, Toni Brown, Moses Lee, Justin B. Jones
Publikováno v:
Synthetic Communications. 38:33-44
Four N‐formamido‐containing mono‐and diheterocyclic pyrrole‐ and imidazole‐2‐containing acids 1–4 were synthesized as intermediates for the preparation of polyamide molecules. The N‐formamido‐moiety forces the compounds to bind stro
Autor:
Hilary Mackay, Peter B. Uthe, John A Hartley, Toni Brown, Moses Lee, W. David Wilson, Justin B. Jones, Caroline O'Hare, Binh Nguyen, Kevin N. Blackmon
Publikováno v:
Biochemistry. 46:11661-11670
The polyamide N-formamido imidazole-pyrrole-imidazole (f-ImPyIm) binds with an exceptionally high affinity for its cognate site 5'-ACGCGT-3' as a stacked, staggered, and noncovalent cooperative dimer. Investigations are presented into its sequence sp
Autor:
Zarmeen T. Taherbhai, Justin B. Jones, Michelle Stewart, Caroline O'Hare, David Wilson, Toni Brown, Binh Nguyen, Hilary Mackay, Moses Lee, Jerome Kluza, Lindsay Stallings, John A. Hartley, Mark Turlington, Karen L. Buchmueller, Jim S. Sexton, Arden Sutterfield
Publikováno v:
Bioorganicmedicinal chemistry. 15(1)
Five polyamide derivatives with rationally modified C-terminus moieties were synthesized and their DNA binding specificity and affinity determined. A convergent approach was employed to synthesize polyamides containing an alkylaminopiperazine (4 and
Autor:
Justin B. Jones, Peter B. Uthe, Andrew M. Staples, Karen L. Buchmueller, Suzanna L. Bailey, Mark Turlington, Moses Lee, Kevin N. Blackmon
Publikováno v:
Heterocyclic Communications. 11