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pro vyhledávání: '"Justin B. Green"'
Autor:
Cindy Duysburgh, Lisa Miclotte, Justin B. Green, Kevin T. Watts, Maria I. Sardi, Anirikh Chakrabarti, Ehsan Khafipour, Massimo Marzorati
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
The yeast-based postbiotic EpiCor is a well-studied formulation, consisting of a complex mixture of bioactive molecules. In clinical studies, EpiCor postbiotic has been shown to reduce intestinal symptoms in a constipated population and support mucos
Externí odkaz:
https://doaj.org/article/cfb85771312b45e3a17f534874a4f2ce
Publikováno v:
Molecular Cell. 11:1537-1548
The Nanos protein gradient in Drosophila, required for proper abdominal segmentation, is generated in part via translational repression of its mRNA by Smaug. We report here the crystal structure of the Smaug RNA binding domain, which shows no sequenc
Autor:
Justin B. Green, Robin P. Wharton, Aneel K. Aggarwal, Carlos R. Escalante, Thomas A. Edwards, José Trincão
Publikováno v:
Biochemical and Biophysical Research Communications. 297:1085-1088
During Drosophila embryogenesis, Smaug protein represses translation of Nanos through an interaction with a specific element in its 3(')UTR. The repression occurs in the bulk cytoplasm of the embryo; Nanos is, however, successfully translated in the
Autor:
Arbi Khodadadi, Peter Haeberli, Leonid Beigelman, Qiaolian Liu, Anna Marie Pyle, Justin B. Green
Publikováno v:
Journal of Molecular Biology. 267:163-171
The 2′-hydroxyl on a specific bulged adenosine is the nucleophile during the first step of splicing by group II introns. To understand the means by which the ribozyme core recognizes this adenosine, it was mutagenized and effects on catalytic activ
Autor:
Justin B. Green, Anna Marie Pyle
Publikováno v:
Biochemistry. 33(9)
Ribozyme kinetics and binding studies of a two-piece group II intron were used to mechanistically characterize a reaction analogous to the first step of RNA splicing. Domain 5 RNA (D5) catalyzes specific hydrolysis of an RNA substrate (exD123) compos