Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Justin B. Goh"'
Autor:
Charlotte C. Williams, Simon Puttick, Nicholas Lyons, Lesley A. Pearce, Lewis Perrin, Thomas Hodgkinson, Tashbib Khan, Trent P. Munro, Sinead Barry, Michael D. Lee, Timothy E. Adams, C. Blake Gilks, Thomas Kryza, Rohan Lourie, Claire M. Davies, Yaowu He, Madeline Gough, John D. Hooper, Justin B. Goh, Martina L. Jones, Rebecca Rogers, Naven Chetty
Publikováno v:
Molecular pharmaceutics. 18(9)
Optimal cytoreduction for ovarian cancer is often challenging because of aggressive tumor biology and advanced stage. It is a critical issue since the extent of residual disease after surgery is the key predictor of ovarian cancer patient survival. F
Autor:
Ariel Isaacs, Naphak Modhiran, James G. Barnes, Christopher L. D. McMillan, Koert J. Stittelaar, Tram Phan, Patrick C. Reading, Geert van Amerongen, Francesca L Mordant, Stacey T. M. Cheung, Connor Scott, Eve Radunz, Daniel Watterson, Louis Lu, Alberto A. Amarilla, Lukasz Kowalczyk, Mai Tran, Mallory Daleris, David A. Brockman, Marianne Gillard, Sherry J. Morgan, Zheyi Li, Noushin Jaberolansar, Julia Lackenby, Michael S. Avumegah, David Edwards, Kym Hoger, Karen Hughes, Judith A. Scoble, Charani Ranasinghe, Qi Zhou, Danushka K. Wijesundara, Fernando Villalon Letelier, Martina L. Jones, Ben Hughes, Kanta Subbarao, Mylinh La, Keith J. Chappell, Summa Bibby, Peter Tapley, Andrew Young, Cora Lau, Lesley A. Pearce, Tam Pham, Trent P. Munro, Paul R. Young, Alexander A. Khromykh, Justin B. Goh, Kate Guilfoyle
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate vaccines now in clinical evaluation. Here we describe the preclinical development of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f9211287e21428829cd16fc490c77f
https://doi.org/10.21203/rs.3.rs-68892/v1
https://doi.org/10.21203/rs.3.rs-68892/v1
Autor:
Francesca L Mordant, Danushka K. Wijesundara, Keith J. Chappell, Cora Lau, Naphak Modhiran, Kanta Subbarao, Stacey T. M. Cheung, Ariel Isaacs, Charani Ranasinghe, Julia Lackenby, Martina L. Jones, Qi Zhou, Eve Radunz, James G. Barnes, Kate Guilfoyle, Koert J. Stittelaar, Zheyi Li, Peter Tapley, Justin B. Goh, Tram Phan, Karen Hughes, Judith M. A. van den Brand, Noushin Jaberolansar, Benjamin S. Hughes, Sherry J. Morgan, Connor A. P. Scott, Judith A. Scoble, Trent P. Munro, Tam Pham, Patrick C. Reading, Mai H. Tran, Andrew Young, Fernando Villalón-Letelier, Marianne Gillard, Lesley A. Pearce, Michael S. Avumegah, Mylinh La, Summa Bibby, Christopher L. D. McMillan, Daniel Watterson, Lukasz Kowalczyk, Mallory Daleris, Paul R. Young, Louis Lu, Alberto A. Amarilla, Alexander A. Khromykh, David Edwards, Kym Hoger, Geert van Amerongen, David A. Brockman
Publikováno v:
SSRN Electronic Journal.
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace. Here we describe rational antigen design through to manufacturability and vaccine efficacy, of a prefusion-stabili
Autor:
Meng How Tan, Ali Gowher, Justin B. Goh, Harini Srinivasan, Andy Hee-Meng Tan, Hsueh Lee Lim, Christine Lin Chin, Raghuvaran Shanmugam, Terry Nguyen-Khuong, Matthew S F Choo, Wen Qin Tang, Kaiwen Ivy Liu, Say Kong Ng
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Mammalian host cell lines are the preferred expression systems for the manufacture of complex therapeutics and recombinant proteins. However, the most utilized mammalian host systems, namely Chinese hamster ovary (CHO), Sp2/0 and NS0 mouse myeloma ce
Autor:
Say Kong Ng, Justin B. Goh
Publikováno v:
Critical reviews in biotechnology. 38(6)
Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glyca
Autor:
Gregory J. Anderson, V. Nathan Subramaniam, Paul C. Adams, Katrina J. Allen, Grant A. Ramm, Justin B. Goh, Pradyumna D. Phatak, Tin Louie, Cameron J. McDonald, Mary J. Emond, Lawrie W. Powell, Gordon D. McLaren, James C. Barton, Deborah A. Nickerson, Christine E. McLaren, Lyle C. Gurrin
Publikováno v:
McLaren, Christine E; Emond, Mary J; Subramaniam, V. Nathan; Phatak, Pradyumna D; Barton, James C; Adams, Paul C; et al.(2015). Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology, 62(2), 429-439. doi: 10.1002/hep.27711. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/4zz4x6d6
To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or w
Publikováno v:
Scientific Reports
BMP-SMAD signalling plays a crucial role in numerous biological processes including embryonic development and iron homeostasis. Dysregulation of the iron-regulatory hormone hepcidin is associated with many clinical iron-related disorders. We hypothes
Publikováno v:
Cell cycle (Georgetown, Tex.). 9(15)
During mitosis, the Golgi undergoes two sequential fragmentation steps to break from ribbon to individual stacks, then from stacks to vesicles. While the mechanism that regulates the first step has been studied, it remains obscure how the second vesi
Autor:
Christine E. McLaren, Tin Louie, Paul C. Adams, Gordon D. McLaren, Deborah A. Nickerson, Cameron J. McDonald, James C. Barton, Lyle C. Gurrin, Gregory J. Anderson, Mary J. Emond, Pradyumna D. Phatak, Katrina J. Allen, Grant A. Ramm, Lawrie W. Powell, V. Nathan Subramaniam, Justin B. Goh
Publikováno v:
Blood. 124:745-745
Variability in the severity of iron overload among homozygotes for the HFE C282Y polymorphism is one of the major unsolved problems in our understanding of hereditary hemochromatosis (HH). We previously conducted exome sequencing of DNA from 35 HFE C