Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Justin B Siegel"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012248 (2024)
Protein stability plays a crucial role in a variety of applications, such as food processing, therapeutics, and the identification of pathogenic mutations. Engineering campaigns commonly seek to improve protein stability, and there is a strong intere
Externí odkaz:
https://doaj.org/article/372a48f2af3f427c87d296f3abe4448b
Autor:
Jayce E. Taylor, Dileep Sai Kumar Palur, Angela Zhang, Jake N. Gonzales, Augustine Arredondo, Timothy A. Coulther, Amiruddin Bin Johan Lechner, Elys P. Rodriguez, Oliver Fiehn, John Didzbalis, Justin B. Siegel, Shota Atsumi
Publikováno v:
npj Science of Food, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Due to the rampant rise in obesity and diabetes, consumers are desperately seeking for ways to reduce their sugar intake, but to date there are no options that are both accessible and without sacrifice of palatability. One of the most promis
Externí odkaz:
https://doaj.org/article/190e204543a54d8ebf6cc3d4736209cb
Autor:
Wai Shun Mak, Chloe P. Jones, Kevin E. McBride, Emily A. P. Fritz, Julie Hirsch, J. Bruce German, Justin B. Siegel
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
IntroductionHistorically, prioritizing abundant food production often resulted in overlooking nutrient quality and bioavailability, however, environmental concerns have now propelled sustainable nutrition and health efficacy to the forefront of globa
Externí odkaz:
https://doaj.org/article/8d9e0b28537a4f3c91432f7a8d0603a7
Autor:
Edward King, Sarah Maxel, Yulai Zhang, Karissa C. Kenney, Youtian Cui, Emma Luu, Justin B. Siegel, Gregory A. Weiss, Ray Luo, Han Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Engineering enzymes to accept noncanonical cofactor biomimetics is difficult. Here, the authors establish a self-sufficient growth selection method and demonstrate its application in engineering the Lactobacillus pentosus NADH oxidase to efficiently
Externí odkaz:
https://doaj.org/article/41cd426163c543aaa20d2d073663935b
Autor:
Linyue Zhang, Edward King, William B. Black, Christian M. Heckmann, Allison Wolder, Youtian Cui, Francis Nicklen, Justin B. Siegel, Ray Luo, Caroline E. Paul, Han Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Engineering enzymes to utilize the noncanonical redox cofactors such as nicotinamide mononucleotide (NMN + ) is challenging. Here, the authors report a growth-based selection platform for NMN + -reducing enzyme engineering and show its application in
Externí odkaz:
https://doaj.org/article/75d6e8408c81418bb081b0cb20fbd5ad
Autor:
Julia Koehler Leman, Sergey Lyskov, Steven M. Lewis, Jared Adolf-Bryfogle, Rebecca F. Alford, Kyle Barlow, Ziv Ben-Aharon, Daniel Farrell, Jason Fell, William A. Hansen, Ameya Harmalkar, Jeliazko Jeliazkov, Georg Kuenze, Justyna D. Krys, Ajasja Ljubetič, Amanda L. Loshbaugh, Jack Maguire, Rocco Moretti, Vikram Khipple Mulligan, Morgan L. Nance, Phuong T. Nguyen, Shane Ó Conchúir, Shourya S. Roy Burman, Rituparna Samanta, Shannon T. Smith, Frank Teets, Johanna K. S. Tiemann, Andrew Watkins, Hope Woods, Brahm J. Yachnin, Christopher D. Bahl, Chris Bailey-Kellogg, David Baker, Rhiju Das, Frank DiMaio, Sagar D. Khare, Tanja Kortemme, Jason W. Labonte, Kresten Lindorff-Larsen, Jens Meiler, William Schief, Ora Schueler-Furman, Justin B. Siegel, Amelie Stein, Vladimir Yarov-Yarovoy, Brian Kuhlman, Andrew Leaver-Fay, Dominik Gront, Jeffrey J. Gray, Richard Bonneau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Computational methods are becoming an increasingly important part of biological research. Using the Rosetta framework as an example, the authors demonstrate how community-driven development of computational methods can be done in a reproducible and r
Externí odkaz:
https://doaj.org/article/7ccba8c202cd473d906c246ef7b2eb77
Autor:
Ashley Vater, Ryan Caster, Hugh Haddox, Audrey Olshefsky, Meerit Said, Neil P. King, Justin B. Siegel
Publikováno v:
Frontiers in Education, Vol 7 (2022)
In response to the limited research experiences for young scholars during the COVID-19 pandemic and community interest, we developed the Pre-College Rosetta Internship Opportunity (PCR-IO). The mission of PCR-IO was to offer a program to increase equ
Externí odkaz:
https://doaj.org/article/eda8668fde374c5a86ef078ef61ef58b
Autor:
SeHee Park, Erin E. Doherty, Yixuan Xie, Anil K. Padyana, Fang Fang, Yue Zhang, Agya Karki, Carlito B. Lebrilla, Justin B. Siegel, Peter A. Beal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesi
Externí odkaz:
https://doaj.org/article/2cab59460beb46e3b35941eb8878c251
Autor:
Peishan Huang, Simon K. S. Chu, Henrique N. Frizzo, Morgan P. Connolly, Ryan W. Caster, Justin B. Siegel
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6487-6493 (2020)
Externí odkaz:
https://doaj.org/article/6d14fbe83dc54681a21279f6c29227f5
Publikováno v:
ACS Omega, Vol 4, Iss 27, Pp 22356-22362 (2019)
Externí odkaz:
https://doaj.org/article/b27e91eddb4341b4b895b7d46259f7a1