Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Justin A. Smolen"'
Autor:
Justin A Smolen, Karen L Wooley
Publikováno v:
PNAS Nexus. 1
Convolutional neural networks (CNNs) and other deep-learning models have proven to be transformative tools for the automated analysis of microscopy images, particularly in the domain of cellular and tissue imaging. These computer-vision models have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0bf1270fb763abbfad62dcc9936a60
https://doi.org/10.1093/pnasnexus/pgac235
https://doi.org/10.1093/pnasnexus/pgac235
Autor:
Fuwu Zhang, Lu Su, Ronan MacLoughlin, Justin A. Smolen, Ryan Clanton, Andrew Sterling Butters, Yue Song, Karen L. Wooley, Yen-Nan Lin, Richen Li, Sarosh Khan, Soleil Hernandez, Gamal Akabani, Jingwei Fan, Hai Wang
Publikováno v:
Journal of the American Chemical Society. 140:1438-1446
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7518fd85923e6cbca10a92818d49d6
https://doi.org/10.1021/jacs.7b11462
https://doi.org/10.1021/jacs.7b11462
Autor:
Karen L. Wooley, Justin A. Smolen, Yue Song, Hai Wang, Lu Su, Yen-Nan Lin, Mei Dong, Richen Li
Publikováno v:
Materials Chemistry Frontiers. 2:2230-2238
The development of next-generation smart nanocarriers that can be tailored for specific applications requires precise control over physiochemical properties, yet modulation of nanostructures solely through synthetic routes is a time-consuming and lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7d8d7221f48fccb7d10ecf66b557be
https://doi.org/10.1039/c8qm00353j
https://doi.org/10.1039/c8qm00353j
Autor:
Guizhi Zhu, Xiaoyuan Chen, Richen Li, Justin A. Smolen, Fuwu Zhang, Lu Su, Shiyi Zhang, Ashlee A. Jahnke, Karen L. Wooley, Sarosh Khan, Mahmoud Elsabahy
Publikováno v:
Nanoscale. 9:15773-15777
Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL-1. The dual-loaded nanoparticles were ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7733e5ee5cc0373196cdf27f1e55a7
https://doi.org/10.1039/c7nr05935c
https://doi.org/10.1039/c7nr05935c
Autor:
Qingquan Chen, S.B. Simbassa, Justin A. Smolen, M.E. Ilanga, Bhagath Chirra, O.O. Ogun, Parth N. Shah, Carolyn L. Cannon, Jasur A. Tagaev
Publikováno v:
A53. CLINICAL STUDIES IN NEONATAL AND PEDIATRIC LUNG DISEASE AND CYSTIC FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc80b40dc6f106f5af87d1dd3053f7e
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1914
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1914
Autor:
Wiley J. Youngs, Karen L. Wooley, Lan Zhou, Carolyn L. Cannon, Justin A. Smolen, Matthew J. Panzner, Kush N. Shah, Jose R. Torrealba, Patrick O. Wagers, Fuwu Zhang, Shiyi Zhang, Parth N. Shah, Jasur A. Tagaev
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
To address the escalating problem of antimicrobial resistance and the dwindling antimicrobial pipeline, we have developed a library of novel aerosolizable silver-based antimicrobials, particularly for the treatment of pulmonary infections. To rapidly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d90fe0101011a59c765a08b038322b
http://europepmc.org/articles/PMC5913254
http://europepmc.org/articles/PMC5913254
Autor:
Henry H. Le, Parth N. Shah, Jasur A. Tagaev, Kimberly R. Marshall-Batty, Qingquan Chen, Carolyn L. Cannon, David E. Greenberg, Vernita Gordon, Justin A. Smolen, Christopher A. Rodesney
Publikováno v:
Antimicrobial Agents and Chemotherapy
Clinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF) patients, an effect that is currently attributed to ibuprofen's anti-inflammatory properties. Yet, a few previous reports demonstrated an antimicrobial activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cc3a191258fddc0e80962d6364ead4
http://europepmc.org/articles/PMC5826130
http://europepmc.org/articles/PMC5826130
Autor:
Carolyn L. Cannon, Karen L. Wooley, Hai Wang, Jeffery E. Raymond, Shiyi Zhang, Richen Li, Fuwu Zhang, Parth N. Shah, Justin A. Smolen, Sangho Cho
Publikováno v:
Nanoscale. 7:2265-2270
In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce82c2599fa116afa8cd8264bab9f821
https://doi.org/10.1039/c4nr07103d
https://doi.org/10.1039/c4nr07103d
Autor:
Justin Alexander Smolen, Kush N. Shah, Rolando J. Ramirez, John J Reho, James H. Holda, Yang H. Yun, Andrew J. Ditto
Publikováno v:
Molecular Pharmaceutics. 10:1836-1844
The concept of gene therapy is promising; however, the perceived risks and side effects associated with this technology have severely dampened the researchers' enthusiasm. Thus, the development of a nonviral gene vector without immunological effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e0ec55f75de544c96579dc15b240cc
https://doi.org/10.1021/mp300623a
https://doi.org/10.1021/mp300623a
Autor:
Jasur A. Tagaev, Parth N. Shah, Jessica Cohen, Matthew J. Panzner, Cátia Ornelas-Megiatto, Carolyn L. Cannon, Jean M. J. Fréchet, Wiley J. Youngs, Brian D. Wright, Justin A. Smolen, Peter Wich
Degradable acetalated dextran (Ac-DEX) nanoparticles were prepared and loaded with a hydrophobic silver carbene complex (SCC) by a single-emulsion process. The resulting particles were characterized for morphology and size distribution using scanning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5626a9a3d4e908346c482d9752b2c6
https://europepmc.org/articles/PMC3579655/
https://europepmc.org/articles/PMC3579655/
