Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Justin A. MacDonald"'
Autor:
Sara R. Turner, Abdulhameed Al‐Ghabkari, David A. Carlson, Mona Chappellaz, Cindy Sutherland, Timothy A. J. Haystead, William C. Cole, Justin A. MacDonald
Publikováno v:
Experimental Physiology, Vol 108, Iss 7, Pp 986-997 (2023)
Abstract The vascular smooth muscle (VSM) of resistance blood vessels is a target of intrinsic autoregulatory responses to increased intraluminal pressure, the myogenic response. In the brain, the myogenic reactivity of cerebral arteries is critical
Externí odkaz:
https://doaj.org/article/c8e96dfe37be4ac3bc4b558c848ca3ff
Autor:
Yang Yang, Biao Ma, Mahbod Djamshidi, Qingrun Zhang, Anusi Sarkar, Ayan Chanda, Uyen Tran, Jung Soh, Christina Sandall, Huey-Miin Chen, Justin A. MacDonald, Shirin Bonni, Christoph W. Sensen, Jianhua Zheng, Karl Riabowol
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 3, Pp 151341- (2023)
ING1 is a chromatin targeting subunit of the Sin3a histone deacetylase (HDAC) complex that alters chromatin structure to subsequently regulate gene expression. We find that ING1 knockdown increases expression of Twist1, Zeb 1&2, Snai1, Bmi1 and TSHZ1
Externí odkaz:
https://doaj.org/article/1436a51a89e047f3b13b738b31e903d7
Autor:
Huey-Miin Chen, Justin A. MacDonald
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101168- (2022)
Summary: Advances in high-throughput sequencing technologies now yield unprecedented volumes of OMICs data with opportunities to conduct systematic data analyses and derive novel biological insights. Here, we provide protocols to perform differential
Externí odkaz:
https://doaj.org/article/c96d77d988594482b7271778f9fe0953
Autor:
Huey-Miin Chen, Justin A. MacDonald
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102831- (2021)
Summary: Colon adenocarcinoma is a prevalent malignancy with significant mortality. Hence, the identification of molecular biomarkers with prognostic significance is important for improved treatment and patient outcomes. Clinical traits and RNA-Seq o
Externí odkaz:
https://doaj.org/article/0b48a942e2ab4f3cb8f53ba943ecf846
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
Speech comprehension is often thought of as an entirely auditory process, but both normal hearing and hearing-impaired individuals sometimes use visual attention to disambiguate speech, particularly when it is difficult to hear. Many studies have inv
Externí odkaz:
https://doaj.org/article/665bd2e0e2504e8198fa1c2e5159d7fc
Publikováno v:
MethodsX, Vol 5, Iss , Pp 466-474 (2018)
The phosphorylation of myosin regulatory light chain (LC20) at Thr18 and Ser19 is positively correlated with tension development in smooth muscle tissue, and the molar stoichiometry of LC20 phosphorylation is commonly profiled as a measure of smooth
Externí odkaz:
https://doaj.org/article/66011ed48019497e97cf0c78f8c87b72
Autor:
Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Publikováno v:
Molecules, Vol 26, Iss 13, p 3975 (2021)
In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]im
Externí odkaz:
https://doaj.org/article/3c3494cec8624421abf07d12c3ebe214
Autor:
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1525-1536.e7 (2018)
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear. Shiga toxin 2 (Stx2)/LPS complex, from pathogenic enter
Externí odkaz:
https://doaj.org/article/b1fc8d30a7c34e8d876e21e962d781d8
Publikováno v:
Molecules, Vol 25, Iss 19, p 4572 (2020)
The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes nucleotide-dependent activation of the NLR downstream of pathogen- or danger-associated molecular pattern (PAMP or DAMP) recognition, followed by nucleation of hetero-o
Externí odkaz:
https://doaj.org/article/e888ae0f8c2646d08ebffb1a9f941b76
Autor:
Joshua Y. Lee, Simon A. Hirota, Louise E. Glover, Glen D. Armstrong, Paul L. Beck, Justin A. MacDonald
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 2, Pp 417-430 (2013)
Background/Aims: Stabilization of the hypoxia-inducible factor (HIF-1α) is proposed to provide a protective host-response to C. difficile intoxication. Here, we aimed to elucidate whether nitric oxide and/or reactive oxygen species produced during C
Externí odkaz:
https://doaj.org/article/24681ee2f2944602bad318ab2c2da620