Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Justin A. Fletcher"'
Autor:
Xiaorong Fu, Justin A. Fletcher, Stanisław Deja, Melissa Inigo-Vollmer, Shawn C. Burgess, Jeffrey D. Browning
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated, and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver (NAFL). Fasting normally relaxes DNL-mediated inhibition of hepati
Externí odkaz:
https://doaj.org/article/759d699f134e4b338a78e82adc8cb48b
Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and RatsSummary
Autor:
Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2-/- mice replicate the human phenotype but were n
Externí odkaz:
https://doaj.org/article/c5db73b318e84203a8ba20887dfcb81f
Autor:
Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice followi
Externí odkaz:
https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
Publikováno v:
FEBS Open Bio, Vol 14, Iss 3, Pp 434-443 (2024)
Type 1 diabetes (T1D) is an autoimmune disease initiated by genetic predisposition and environmental influences, which result in the specific destruction of insulin‐producing pancreatic β‐cells. Currently, there are over 1.6 million cases of T1D
Externí odkaz:
https://doaj.org/article/1211d3c5ecbf4a9fac4cb6421c0b3831
Autor:
Jeremiah W. Sanders, Justin R. Fletcher, Steven J. Frank, Ho-Ling Liu, Jason M. Johnson, Zijian Zhou, Henry Szu-Meng Chen, Aradhana M. Venkatesan, Rajat J. Kudchadker, Mark D. Pagel, Jingfei Ma
Publikováno v:
SoftwareX, Vol 10, Iss , Pp - (2019)
Herein we introduce a deep learning (DL) application engine (DLAE) system concept, present potential uses of it, and describe pathways for its integration in clinical workflows. An open-source software application was developed to provide a code-free
Externí odkaz:
https://doaj.org/article/e6f24710d2ba43f0994a632d08a24f1e
Autor:
Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2-/- mice replicate the human phenotype but were n
Autor:
MELISSA MAE R. INIGO, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, GAURAV SHARMA, STANISLAW DEJA, XIAORONG FU, SHAWN C. BURGESS
Publikováno v:
Diabetes. 71
Redox balance is critical for numerous cellular functions, including substrate oxidation, biosynthesis, and antioxidant defenses. Redox homeostasis is dysregulated in many metabolic diseases, including obesity and Type 2 diabetes. In addition to its
Autor:
STANISLAW DEJA, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, MONIKA N. MIZERSKA, XIAORONG FU, CHAI-WAN KIM, JEFFREY BROWNING, JAMEY YOUNG, JAY D. HORTON, SHAWN C. BURGESS
Publikováno v:
Diabetes. 71
Activation of fatty acid oxidation is a promising therapy for NAFLD. Lowering acetyl-CoA carboxylase (ACC) activity depletes malonyl-CoA, activates CPT1, and increases mitochondrial fatty acid delivery. ACC1/2 liver double KO mice (LDKO) are protecte
Publikováno v:
Algorithms, Technologies, and Applications for Multispectral and Hyperspectral Imaging XXVIII.
Autor:
Arielle Sharp-Tawfik, Justin D. Fletcher, Jennifer Guergues, Catherine Marelia-Bennett, Tiara J. Wolf, Alexis M. Coiner, Y. Clare Zhang, Stanley M. Stevens, Brant R. Burkhardt
Publikováno v:
Molecular and cellular endocrinology. 557
Type 1 diabetes (T1D) is an autoimmune disease initiated by genetic predisposition and environmental influences culminating in the immunologically mediated destruction of pancreatic β-cells with eventual loss of insulin production. Although T1D can