Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Justin A. English"'
Autor:
Andrew J. Tao, Jiewei Jiang, Gillian E. Gadbois, Pavitra Goyal, Bridget T. Boyle, Elizabeth J. Mumby, Samuel A. Myers, Justin G. English, Fleur M. Ferguson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small
Externí odkaz:
https://doaj.org/article/7e60e12c82e148d7ba52ad726511fade
Autor:
Braden S Fallon, Justin G English
Publikováno v:
eLife, Vol 11 (2022)
Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated with many diseases.
Externí odkaz:
https://doaj.org/article/471ffbf071f24931983c2ece63b46626
Autor:
Adam M. Zahm, William S. Owens, Samuel R. Himes, Kathleen E. Rondem, Braden S. Fallon, Alexa N. Gormick, Joshua S. Bloom, Sriram Kosuri, Henry Chan, Justin G. English
Cellular transcription enables cells to adapt to various stimuli and maintain homeostasis. Transcription factors bind to transcription response elements (TREs) in gene promoters, initiating transcription. Synthetic promoters, derived from natural TRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed21810dc85f327bb4adc5de82dc9af5
https://doi.org/10.1101/2023.05.11.539703
https://doi.org/10.1101/2023.05.11.539703
Autor:
Samuel T. Slocum, Yongfeng Liu, Bryan L. Roth, Jian Jin, Brian E. Krumm, Brian J. Bender, Reid H.J. Olsen, Hye Jin Kang, Justin G. English, Isha Singh, Jing Liu, Lily Yeh Jan, Wenlei Ye, Brian K. Shoichet, Xi Ping Huang, Byron W. Hayes, Can Cao, John D. McCorvy, Jonathan F. Fay, Katherine Lansu, Soman N. Abraham, Shicheng Zhang, Chengwei Zhang, Wesley K. Kroeze, Kuglae Kim, He Chen, Ryan H. Gumpper, Jeffrey F. DiBerto, Joel Karpiak
Publikováno v:
Nature
Nature, vol 600, iss 7887
Nature, vol 600, iss 7887
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e74bb609d8bd744fc782cf9ab54a3d
https://doi.org/10.1038/s41586-021-04126-6
https://doi.org/10.1038/s41586-021-04126-6
Autor:
Reid H. J. Olsen, Justin G. English
Publikováno v:
British journal of pharmacologyREFERENCES.
Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157fc5706efabadb7676f62616a997a2
https://pubmed.ncbi.nlm.nih.gov/36166832
https://pubmed.ncbi.nlm.nih.gov/36166832
Autor:
Justin G. English, Toshiyuki Hirabayashi, Jing Liu, Koki Mimura, Masahiko Takada, Jin Nakahara, Tetsuya Suhara, Jian Jin, Naohisa Miyakawa, Bin Ji, Yukiko Hori, Maiko Ono, Manami Takahashi, Yan Xiong, Jeffrey F. DiBerto, Ken-ichi Inoue, Bryan L. Roth, Masafumi Shimojo, Chie Seki, Atsushi Fujimoto, Kei Oyama, Samuel T. Slocum, Yuji Nagai, Xi Ping Huang, Yutaka Tomita, Takafumi Minamimoto, Katsushi Kumata, Makoto Higuchi, Hiroyuki Takuwa, Ming-Rong Zhang, Takuya Urushihata
Publikováno v:
Nature Neuroscience. 23:1157-1167
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with cloza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f969bef8a60a645242632bbca53a4820
https://doi.org/10.1038/s41593-020-0661-3
https://doi.org/10.1038/s41593-020-0661-3
Autor:
Ariana C. Gavin, Reid H.J. Olsen, Tao Che, Justin G. English, Samuel T. Slocum, Ryan T. Strachan, Bryan L. Roth, Jeffrey F. DiBerto, Brian E. Krumm, John D. McCorvy, Alexis M. Glaudin
Publikováno v:
Nature chemical biology
G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the transducerome) to exert their actions. To address this g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe11a535c3f5d1f62296cd9573f815
https://doi.org/10.1038/s41589-020-0535-8
https://doi.org/10.1038/s41589-020-0535-8
Autor:
Els Pardon, Justin G. English, F. Ivy Carroll, Brian E. Krumm, Jeffrey F. DiBerto, Bryan L. Roth, Noah Sciaky, Sheng Wang, Reid H.J. Olsen, Tao Che, Daniel Wacker, Shicheng Zhang, Kuglae Kim, Jan Steyaert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a relative lack of suitable tools. We previously reported two nanobodies (Nb39 and Nb6) that sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664ff244c7e7405559e63bc768c4edf8
http://link.springer.com/article/10.1038/s41467-020-14889-7
http://link.springer.com/article/10.1038/s41467-020-14889-7
Autor:
Mark Eldridge, Brittany Aguilar, Mark G Baxter, James A. Bourne, Verginia C. Cuzon Carlson, Benjamin E. Deverman, Justin G. English, Arnaud Y. Falchier, Andrew S. Fox, Adriana Galvan, Kathleen A. Grant, Ken-ichi Inoue, Jian Jin, Ned H. Kalin, Thomas L Kash, Ludise Malkova, Mike Michaelides, Takafumi Minamimoto, Mineki Oguchi, Jessica Raper, Peter H. Rudebeck, Masamichi Sakagami, William R. Stauffer, Scott M. Sternson, Masahiko Takada, Barry J. Richmond
Molecular tools - such as chemogenetics, optogenetics, and calcium sensors – have been shown in small animals, e.g., mice, zebrafish, and flies, to be powerful tools for studying the mechanisms underlying brain function. The adoption of molecular t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf4857e1bea7332763862496960d364
https://doi.org/10.31219/osf.io/abz3j
https://doi.org/10.31219/osf.io/abz3j