Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Justin A, Shyer"'
Autor:
Alessandra Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni, Ryan S. Lane, Amber W. Wang, Justin A. Shyer, Zhe Zhang, Stephanie Mittman, Alan Gutierrez, Jillian L. Astarita, Minh Thai, Jeffrey Hung, Yeqing Angela Yang, Tony Pourmohamad, Patricia Himmels, Marco De Simone, Justin Elstrott, Aude-Hélène Capietto, Rafael Cubas, Zora Modrusan, Wendy Sandoval, James Ziai, Stephen E. Gould, Wenxian Fu, Yulei Wang, James T. Koerber, Shomyseh Sanjabi, Ira Mellman, Shannon J. Turley, Sören Müller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed
Externí odkaz:
https://doaj.org/article/fa5b40b8c1aa4ad3abed292446b9c3af
Autor:
Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai, Vineela Gandham, Matthew B. Buechler, Yeqing Angela Yang, Rachana N. Pradhan, Amber W. Wang, Patricia L. Sanchez, Yan Qu, Beatrice Breart, Cécile Chalouni, Debra Dunlap, James Ziai, Justin Elstrott, Neelie Zacharias, Weiguang Mao, Rebecca K. Rowntree, Jack Sadowsky, Gail D. Lewis, Thomas H. Pillow, Barzin Y. Nabet, Romain Banchereau, Lucinda Tam, Roger Caothien, Natasha Bacarro, Merone Roose-Girma, Zora Modrusan, Sanjeev Mariathasan, Sören Müller, Shannon J. Turley
Publikováno v:
Nature. 611:148-154
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)1–3. However, the molecular sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1180240064ddca96a7dbfb51299c508a
https://doi.org/10.1038/s41586-022-05272-1
https://doi.org/10.1038/s41586-022-05272-1
Autor:
James W. Young, Brian C. Betts, Katharine C. Hsu, Glenn Heller, David J. Chung, Sneh Sharma, Lillian R. Talbot, Erin T. St. Angelo, Justin A. Shyer, Shane A. Curran
Supplemental article file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cca434690cf948ceefe8b327dbb89f
https://doi.org/10.1158/2326-6066.22538822
https://doi.org/10.1158/2326-6066.22538822
Autor:
James W. Young, Brian C. Betts, Katharine C. Hsu, Glenn Heller, David J. Chung, Sneh Sharma, Lillian R. Talbot, Erin T. St. Angelo, Justin A. Shyer, Shane A. Curran
moDC stimulated NK cells retain surface expression of the gamma chain receptor despite the presence of JAK inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da5862ec7bcdea764813cc97e095058
https://doi.org/10.1158/2326-6066.22538825
https://doi.org/10.1158/2326-6066.22538825
Autor:
James W. Young, Brian C. Betts, Katharine C. Hsu, Glenn Heller, David J. Chung, Sneh Sharma, Lillian R. Talbot, Erin T. St. Angelo, Justin A. Shyer, Shane A. Curran
TG101348 and ruxolitinib inhibit JAK2 mediated STAT5 and STAT3 phosphorylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac45a3fd37120fdf4bfb07450ca87f3
https://doi.org/10.1158/2326-6066.22538831.v1
https://doi.org/10.1158/2326-6066.22538831.v1
Autor:
James W. Young, Brian C. Betts, Katharine C. Hsu, Glenn Heller, David J. Chung, Sneh Sharma, Lillian R. Talbot, Erin T. St. Angelo, Justin A. Shyer, Shane A. Curran
Inhibition of JAK1/2 with ruxolitinib reduces NK cell numbers and function among treated patients with myeloproliferative neoplasm (MPN).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad6fd45382878e85b8e86bb1d93b072
https://doi.org/10.1158/2326-6066.22538828.v1
https://doi.org/10.1158/2326-6066.22538828.v1
Autor:
Abhinav Seth, Yoshiyuki Yokokura, Jin-Young Choi, Justin A. Shyer, Aurobind Vidyarthi, Joe Craft
Publikováno v:
Journal of Experimental Medicine. 220
Coordinated gene expression programs enable development and function of T cell subsets. Follicular helper T (Tfh) cells coordinate humoral immune responses by providing selective and instructive cues to germinal center B cells. Here, we show that AP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be82867cb1e7dc6000a6c838c22f7d8
https://doi.org/10.1084/jem.20211110
https://doi.org/10.1084/jem.20211110
Autor:
David J. Chung, Richard D. Carvajal, Michael A. Postow, Sneh Sharma, Katherine B. Pronschinske, Justin A. Shyer, Shahnaz Singh-Kandah, Mark A. Dickson, Sandra P. D'Angelo, Jedd D. Wolchok, James W. Young
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Purpose: We conducted a phase I vaccine trial to determine safety, toxicity, and immunogenicity of autologous Langerhans-type dendritic cells (LCs), electroporated with murine tyrosinase-related peptide-2 (mTRP2) mRNA in patients with resected AJCC s
Externí odkaz:
https://doaj.org/article/3f8a70d8c6f34f29b3bbab139b4f793b
Publikováno v:
Cell Research
Cell Res
Cell Res
The maintenance of organismal homeostasis requires partitioning and transport of biochemical molecules between organ systems, their composite cells, and subcellular organelles. Although transcriptional programming undeniably defines the functional st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20f45f03199c10ee2f92a04b8784ac6
https://doi.org/10.1038/s41422-020-0379-5
https://doi.org/10.1038/s41422-020-0379-5
Autor:
Akshay T, Krishnamurty, Justin A, Shyer, Minh, Thai, Vineela, Gandham, Matthew B, Buechler, Yeqing Angela, Yang, Rachana N, Pradhan, Amber W, Wang, Patricia L, Sanchez, Yan, Qu, Beatrice, Breart, Cécile, Chalouni, Debra, Dunlap, James, Ziai, Justin, Elstrott, Neelie, Zacharias, Weiguang, Mao, Rebecca K, Rowntree, Jack, Sadowsky, Gail D, Lewis, Thomas H, Pillow, Barzin Y, Nabet, Romain, Banchereau, Lucinda, Tam, Roger, Caothien, Natasha, Bacarro, Merone, Roose-Girma, Zora, Modrusan, Sanjeev, Mariathasan, Sören, Müller, Shannon J, Turley
Publikováno v:
Nature. 611(7934)
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59eeda4a38c0af3f0f6cad81ea9ce623
https://pubmed.ncbi.nlm.nih.gov/36171287
https://pubmed.ncbi.nlm.nih.gov/36171287