Evaluation of an icIEF‐MS system for comparable charge variant analysis of biotherapeutics with rapid peak identification by mass spectrometry

Autor: Xiaoping He, Mariam ElNaggar, Maggie A. Ostrowski, Andras Guttman, Erik Gentalen, Justin Sperry

Publikováno v: ELECTROPHORESIS. 43:1215-1222

Protein therapeutics are usually produced in heterogeneous forms during bioproduction and bioprocessing. Heterogeneity results from post-translational modifications that can yield charge variants and require characterization throughout product develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1d6224074a9931f79121e19e77fa15
https://doi.org/10.1002/elps.202100295

The Effect of Physicochemical Modification on the Function of Antibodies Induced by Anti-Nicotine Vaccine in Mice

Autor: Jennifer M. Thorn, Keshab Bhattacharya, Renata Crutcher, Justin Sperry, Colleen Isele, Barbara Kelly, Libbey Yates, James Zobel, Ningli Zhang, Heather L. Davis, Michael J. McCluskie

Publikováno v: Vaccines, Vol 5, Iss 2, p 11 (2017)

Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assisting smoking cessation is via anti-nicotine vaccines, composed of nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). We have previ

Externí odkaz: https://doaj.org/article/c9bde9921e754ec989c485e11d57098d

Shear Wave Velocity Profiles of Roadway Substructures from Multichannel Analysis of Surface Waves and Waveform Tomography

Autor: Scott J. Wasman, David Horhota, Justin Sperry, Khiem T. Tran, Michael McVay

Publikováno v: Transportation Research Record: Journal of the Transportation Research Board. 2655:36-44

Assessment of roadway subsidence caused by embedded low-velocity anomalies is critical to the health and safety of the traveling public. Surface-based seismic techniques are often used to assess roadways because of data acquisition convenience and la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2a4feb04ed037e0410a03a18fdea3c0
https://doi.org/10.3141/2655-06

Erratum to: Metal-binding properties of human centrin-2 determined by micro-electrospray ionization mass spectrometry and UV spectroscopy

Autor: Justin Sperry, Michael L. Gross

Publikováno v: Journal of the American Society for Mass Spectrometry. 17:1481-1481

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3f04800a76e139fa1c0c094bb98caec
https://doi.org/10.1016/j.jasms.2006.08.006

Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates.

Autor: Procopio-Melino, Renée¹ (AUTHOR), Kotch, Frank W.² (AUTHOR) Frank.W.Kotch@pfizer.com, Prashad, Amar S.^2,3 (AUTHOR), Gomes, Jose M.¹ (AUTHOR) Jose.Gomes@pfizer.com, Wang, Wenge¹ (AUTHOR), Arve, Bo² (AUTHOR), Dawdy, Andrew⁴ (AUTHOR) Andrew.W.Dawdy@pfizer.com, Chen, Lawrence⁵ (AUTHOR), Sperry, Justin⁴ (AUTHOR), Hosselet, Christine⁶ (AUTHOR), He, Tao^7,8 (AUTHOR), Kriz, Ronald⁷ (AUTHOR), Lin, Laura⁷ (AUTHOR), Marquette, Kimberly⁷ (AUTHOR), Tchistiakova, Lioudmila⁷ (AUTHOR), Somers, Will⁷ (AUTHOR), Rouse, Jason C.⁵ (AUTHOR), Zhong, Xiaotian⁷ (AUTHOR) Xiaotian.Zhong@pfizer.com

Publikováno v: Scientific Reports. 5/4/2022, Vol. 12 Issue 1, p1-11. 11p.