Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Justin, P Whalley"'
Autor:
Harindra E. Amarasinghe, Ping Zhang, Justin P. Whalley, Alice Allcock, Gabriele Migliorini, Andrew C. Brown, Giuseppe Scozzafava, Julian C. Knight
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune function which are broadly protective but may be dysregulated in disease. Here, we aimed to advanc
Externí odkaz:
https://doaj.org/article/5ab61c5126b04d9f9db2e20d3b2d1e7a
Autor:
Jia-Yuan Zhang, Justin P. Whalley, Julian C. Knight, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively investigated. However, much less is known about the long-term effects of infection in patients
Externí odkaz:
https://doaj.org/article/bac1a98740f949f6be9c6f638e0ecc48
Autor:
Ping Zhang, Harindra E. Amarasinghe, Justin P. Whalley, Chwen Tay, Hai Fang, Gabriele Migliorini, Andrew C. Brown, Alice Allcock, Giuseppe Scozzafava, Phalguni Rath, Benjamin Davies, Julian C. Knight
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Background Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with
Externí odkaz:
https://doaj.org/article/88adf9a2b9bb401395c455a7e384c0a3
Autor:
Elena Navarro-Guerrero, Chwen Tay, Justin P. Whalley, Sally A. Cowley, Ben Davies, Julian C. Knight, Daniel Ebner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Genome engineering using CRISPR/Cas9 technology enables simple, efficient and precise genomic modifications in human cells. Conventional immortalized cell lines can be easily edited or screened using genome-wide libraries with lentiviral tra
Externí odkaz:
https://doaj.org/article/d5d3e85be29a477a8b861f701127b798
Autor:
Justin P. Whalley, Ivo Buchhalter, Esther Rheinbay, Keiran M. Raine, Miranda D. Stobbe, Kortine Kleinheinz, Johannes Werner, Sergi Beltran, Marta Gut, Daniel Hübschmann, Barbara Hutter, Dimitri Livitz, Marc D. Perry, Mara Rosenberg, Gordon Saksena, Jean-Rémi Trotta, Roland Eils, Daniela S. Gerhard, Peter J. Campbell, Matthias Schlesner, Ivo G. Gut
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Working with cancer genomes from multiple projects can increase investigative power, but quality of sequences can vary. Here, the authors present a framework for comparing whole genome sequencing quality to help researchers guide downstream analyses
Externí odkaz:
https://doaj.org/article/ba676c81737441b295bb24df190a545c
Using de novo assembly to identify structural variation of eight complex immune system gene regions.
Autor:
Jia-Yuan Zhang, Hannah Roberts, David S C Flores, Antony J Cutler, Andrew C Brown, Justin P Whalley, Olga Mielczarek, David Buck, Helen Lockstone, Barbara Xella, Karen Oliver, Craig Corton, Emma Betteridge, Rachael Bashford-Rogers, Julian C Knight, John A Todd, Gavin Band
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009254 (2021)
Driven by the necessity to survive environmental pathogens, the human immune system has evolved exceptional diversity and plasticity, to which several factors contribute including inheritable structural polymorphism of the underlying genes. Character
Externí odkaz:
https://doaj.org/article/bea2427071be4bdeb11fe0c7dccabc1c
Autor:
Miranda D Stobbe, Gian A Thun, Andrea Diéguez-Docampo, Meritxell Oliva, Justin P Whalley, Emanuele Raineri, Ivo G Gut
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007496 (2019)
The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sol
Externí odkaz:
https://doaj.org/article/6eed99736a684118816fba2838116440
Autor:
Hew D Torrance, Ping Zhang, E Rebecca Longbottom, Yuxin Mi, Justin P Whalley, Alice Allcock, Andrew J Kwok, Eddie Cano-Gamez, Cyndi G Geoghegan, Katie L Burnham, David B Antcliffe, Emma E Davenport, Rupert M Pearse, Michael J O’Dwyer, Charles J Hinds, Julian C Knight, Anthony C Gordon
RationaleNosocomial infections are a major healthcare challenge, developing in over 20% of patients aged 45 or over undergoing major-abdominal surgery, with postoperative pneumonia associated with an almost five-fold increase in 30-day mortality.Obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd2e4f71bef884190b5e00574bde0ee
https://doi.org/10.1101/2023.01.25.23284914
https://doi.org/10.1101/2023.01.25.23284914
Autor:
Julian C. Knight, Daniel Ebner, Chwen Tay, Justin P. Whalley, Sally A. Cowley, Elena Navarro-Guerrero, Ben Davies
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Genome engineering using CRISPR/Cas9 technology enables simple, efficient and precise genomic modifications in human cells. Conventional immortalized cell lines can be easily edited or screened using genome-wide libraries with lentiviral transduction
Autor:
Miranda D. Stobbe, Justin P. Whalley, Barbara Hutter, Johannes Werner, Dimitri Livitz, Sergi Beltran, Ivo Gut, Daniela S. Gerhard, Marta Gut, Matthias Schlesner, Daniel Hübschmann, Kortine Kleinheinz, Ivo Buchhalter, Peter J. Campbell, Keiran Raine, Mara Rosenberg, Gordon Saksena, Roland Eils, Esther Rheinbay, Marc D. Perry, Jean-Rémi Trotta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
Bringing together cancer genomes from different projects increases power and allows the investigation of pan-cancer, molecular mechanisms. However, working with whole genomes sequenced over several years in different sequencing centres requires a fra