Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Justin, LaVigne"'
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Gabriella Molnar, Dagmara Tymecka, Aleksandra Misicka, John M. Streicher, Victor J. Hruby, Frank Porreca
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 625 (2021)
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://doaj.org/article/5b6b2c3eba6f414bbf633d9023f2ac2b
Autor:
Erika Liktor-Busa, Tally M. Largent-Milnes, Justin LaVigne, Attila Keresztes, John M. Streicher
Publikováno v:
Pharmacological Reviews. 73:1269-1297
Pain prevalence among adults in the United States has increased 25% over the past two decades, resulting in high health-care costs and impacts to patient quality of life. In the last 30 years, our understanding of pain circuits and (intra)cellular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e84c3f57dfe91e6e8b177899cc71bb9d
https://doi.org/10.1124/pharmrev.120.000046
https://doi.org/10.1124/pharmrev.120.000046
Publikováno v:
Pharmacological Reports. 72:465-471
Opioid agonist activation at the mu opioid receptor (MOR) can lead to a wide variety of physiological responses. Many opioid agonists share the ability to selectively and preferentially activate specific signaling pathways, a term called biased agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8073d68c8f655c5cda7323f373c71f
https://doi.org/10.1007/s43440-020-00061-x
https://doi.org/10.1007/s43440-020-00061-x
Autor:
Jason Scott, Monica Soto-Velasquez, Michael Hayes, Justin Lavigne, Heath Miller, Jatinder Kaur, Karin Ejendal, Val Watts, Daniel Flaherty
Adenylyl cyclase type 1 is an emerging target for the treatment of chronic pain that is downstream on the analgesic pathway from the traditional µ-opioid receptor. AC1 is expressed in the central nervous system and critical for signaling in pain sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82bc4e6f9a788650764bc91f161c0670
https://doi.org/10.26434/chemrxiv-2021-h5hhv
https://doi.org/10.26434/chemrxiv-2021-h5hhv
Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes. However this hypothesis is controversial, with limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::746e4b765841a360aa7b71e2ac062a54
https://doi.org/10.1101/2020.10.22.350868
https://doi.org/10.1101/2020.10.22.350868
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Michael Remesic, John M. Streicher, Zhijun Wu, Gabriella Molnar, Victor J. Hruby, Frank Porreca, Yeon Sun Lee, Justin LaVigne, Aleksandra Misicka, Cyf Ramos-Colon, Dagmara Tymecka
Publikováno v:
Biomedicines, Vol 9, Iss 625, p 625 (2021)
Biomedicines
Volume 9
Issue 6
Biomedicines
Volume 9
Issue 6
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae445dd32e36a3c9bd3630575031e6
https://doi.org/10.3390/biomedicines9060625
https://doi.org/10.3390/biomedicines9060625
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc833378332fb32acab14f42f9a1bc68
https://doi.org/10.1096/fasebj.2020.34.s1.04020
https://doi.org/10.1096/fasebj.2020.34.s1.04020
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829d67365eff25b9133ebcf28c7ffc7c
https://doi.org/10.1096/fasebj.2020.34.s1.04622
https://doi.org/10.1096/fasebj.2020.34.s1.04622
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::701f6bbfaee947821893c3aee5cfa439
https://doi.org/10.1096/fasebj.2018.32.1_supplement.689.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.689.3
Autor:
Edward J. Bilsky, Glenn W. Stevenson, Phillip Atherton, Julio Dutra, Robin Polt, John M. Streicher, Denise Giuvelis, Justin LaVigne, Catherine Dunbar, Amy Luginbuhl, Katherine Cone, Brooke Bell
Publikováno v:
Pharmacology Biochemistry and Behavior. 132:49-55
Previous work in our laboratories provides preclinical evidence that mixed-action delta/mu receptor glycopeptides have equivalent efficacy for treating pain with reduced side effect profiles compared to widely used mu agonist analgesics such as morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62b18d2def449971f24316cd76fa6a9
https://doi.org/10.1016/j.pbb.2015.02.022
https://doi.org/10.1016/j.pbb.2015.02.022