Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Just Genius"'
Autor:
Just Genius, Johanna Geiger, Anna-Lena Dölzer, Jens Benninghoff, Ina Giegling, Annette M Hartmann, Hans-Jürgen Möller, Dan Rujescu
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e59395 (2013)
BACKGROUND: The psychotomimetic effects of N-methyl-D-aspartate (NMDA) receptor antagonists in healthy humans and their tendency to aggravate psychotic symptoms in schizophrenic patients have promoted the notion of altered glutamatergic neurotransmis
Externí odkaz:
https://doaj.org/article/c81513c79c5747049f95c3990728641b
Autor:
Just Genius, Johanna Geiger, Andreas Bender, Hans-Jürgen Möller, Thomas Klopstock, Dan Rujescu
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30554 (2012)
Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a re
Externí odkaz:
https://doaj.org/article/809674e423e84124b737ffd69afd54ed
Autor:
Johan Willem Smit, Peter Basile, Maria Key Prato, Laurent Detalle, François‐Xavier Mathy, Astrid Schmidt, Marianna Lalla, Massimiliano Germani, Coralie Domange, Anja‐Leona Biere, Massimo Bani, Stan Carson, Just Genius
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 37(10)
Parkinson's disease (PD) and its progression are thought to be caused and driven by misfolding of α-synuclein (ASYN). UCB0599 is an oral, small-molecule inhibitor of ASYN misfolding, aimed at slowing disease progression.The aim was to investigate sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0af038c0c9daf39a2c798645ebce9f
https://pubmed.ncbi.nlm.nih.gov/35959805
https://pubmed.ncbi.nlm.nih.gov/35959805
Autor:
Hans-Jürgen Möller, Christoph Mulert, Bettina Konte, Just Genius, Oliver Pogarell, Sabine M. Hölter, Susanne Karch, Stephan Maul, Jochen Graw, Dan Rujescu, Thomas Eggert, Gregor Leicht, Ulrich Hegerl, Annette M. Hartmann, Ina Giegling, Andreas Straube
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry
Transl. Psychiatry 10:113 (2020)
Translational Psychiatry
Transl. Psychiatry 10:113 (2020)
βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens before it was detected in various brain regions of the mouse, including the hippocampus and the cerebral cortex. Mutations in the mouse Crybb2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0728fa3ff8730c0ad7f46c0f6db68a65
http://link.springer.com/article/10.1038/s41398-020-0791-0
http://link.springer.com/article/10.1038/s41398-020-0791-0
Autor:
Hans Klafki, Jonas Schartner, Carsten Kötting, Just Genius, Andreas Nabers, Klaus Gerwert, Henning Hafermann, Julian Ollesch, Jens Wiltfang
Publikováno v:
Analytical chemistry 88(5), 2755-2762 (2016). doi:10.1021/acs.analchem.5b04286
The misfolding of the Amyloid-beta (Aβ) peptide into β-sheet enriched conformations was proposed as an early event in Alzheimer's Disease (AD). Here, the Aβ peptide secondary structure distribution in cerebrospinal fluid (CSF) and blood plasma of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080b066b72e021b2a0e329d7ba8ad280
https://doi.org/10.1021/acs.analchem.5b04286
https://doi.org/10.1021/acs.analchem.5b04286
Autor:
Robert J. Schloesser, Jens Benninghoff, Dan Rujescu, Norbert Scherbaum, Dirk M. Hermann, Amelie T. van der Ven, Nadine Fischer, Julius C. Pape, Just Genius, Jens Wiltfang, Rainald Mößner
An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a097b56b0185f4af9d46bfc56f953b64
https://www.ncbi.nlm.nih.gov/pubmed/28269766
https://www.ncbi.nlm.nih.gov/pubmed/28269766
Autor:
Mahesh N. Samtani, Richard Batrla-Utermann, Leslie Carter, Stephen P. Arneric, Janice Hitchcock, Diane Stephenson, Leslie M. Shaw, Tobias Bittner, Hugo Vanderstichele, Brian A. Willis, Robert A. Dean, Robert M. Umek, Mark Forrest Gordon, Kaj Blennow, Sebastiaan Engelborghs, Laurel A. Beckett, Just Genius, Mary J. Savage, Susan Yule, June Kaplow, Klaus Romero, Richard Meibach, David Raunig, Johan Luthman
Publikováno v:
Journal of Alzheimer's disease
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease
Alzheimer’s disease (AD) drug development is burdened with the current requirement to conduct large, lengthy, and costly trials to overcome uncertainty in patient progression and effect size on treatment outcome measures. There is an urgent need fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abeec27633e0987f7d109b2ebddf8fcb
https://biblio.vub.ac.be/vubir/(f861899c-8529-43eb-ad41-c5d512a1de1e).html
https://biblio.vub.ac.be/vubir/(f861899c-8529-43eb-ad41-c5d512a1de1e).html
Autor:
Dan Rujescu, Tomiki Sumiyoshi, Masayoshi Kurachi, Ichiro Takasaki, Tadasu Matsuoka, Takashi Uehara, Hiroko Itoh, Just Genius
Publikováno v:
Synapse. 68:202-208
Schizophrenia is considered as a "neurodegenerative" and "neurodevelopmental" disorder, the pathophysiology of which may include hypofunction of the N-methyl-D-aspartate receptor (NMDA-R) or subsequent pathways. Accordingly, administration of NMDA-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aff13168da0c9ed82f43d2c048a918b
https://doi.org/10.1002/syn.21734
https://doi.org/10.1002/syn.21734
Autor:
Gereon Poschmann, Jens Wiltfang, Wolfgang Wurst, Katrin Seyfarth, Helmut E. Meyer, D. Besong Agbo, Martin Klingenspor, Just Genius, Hans-Wolfgang Klafki, C. Janßen, Kai Stühler
Publikováno v:
Analytical biochemistry 443(2), 197-204 (2013). doi:10.1016/j.ab.2013.09.013
We report on the development of a novel assay protocol for the separation and detection of charge isoforms of DJ-1 in biological samples by automated capillary isoelectric focusing followed by immunological detection. DJ-1 (PARK7) is considered as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7385d47aa3b3a7dc1bd80bf66560df82
https://doi.org/10.1016/j.ab.2013.09.013
https://doi.org/10.1016/j.ab.2013.09.013
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 262:71-77
In light of the dramatically increasing prevalence of Alzheimer's disease (AD) to be expected in the future, the development of novel therapeutics, improved differential and early diagnostics, and means for the identification of individuals at risk a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474de065cc1f040337e2d7401aa13f04
https://doi.org/10.1007/s00406-012-0362-3
https://doi.org/10.1007/s00406-012-0362-3