In Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography

Autor: Pasi Virta, Tiina Laitala-Leinonen, Meeri Käkelä, Harri Lönnberg, Anne Roivainen, Matthieu Bourgery, Riikka Siitonen, Heidi Liljenbäck, Päivi Poijärvi-Virta, Jussi Mäkilä, Satish Jadhav, Kiira Rimpilä

Publikováno v: Molecular Pharmaceutics. 13:2588-2595

A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a (68)Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated 2'-O-methyl oligoribo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bdbb8a661266baa4b0c50e788c55e3
https://doi.org/10.1021/acs.molpharmaceut.6b00261

Synthesis of multi-galactose-conjugated 2´-O-methyl oligoribonucleotides and their in vivo imaging with positron emission tomography

Autor: Pasi Virta, Satish Jadhav, Meeri Käkelä, Harri Lönnberg, Heidi Liljenbäck, Päivi Poijärvi-Virta, Jussi Mäkilä, Anne Roivainen, Anu Kiviniemi, Tiina Laitala-Leinonen

Publikováno v: Bioorganic and Medicinal Chemistry. 22(24):6806-6813

68Ga labelled 2′-O-methyl oligoribonucleotides (anti-miR-15b) bearing one, three or seven d -galactopyranoside residues have been prepared and their distribution in healthy rats has been studied by positron emission tomography (PET). To obtain the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afecd3bfc0293e3e7c97579f7eb24a67
https://doi.org/10.1016/j.bmc.2014.10.034

Solid-Supported NOTA and DOTA Chelators Useful for the Synthesis of 3 '-Radiometalated Oligonucleotides

Autor: Harri Lönnberg, Tiina Saanijoki, Tiina Laitala-Leinonen, Anu Kiviniemi, Joonas Mäkelä, Jussi Mäkilä, Pasi Virta, Anne Roivainen, Heidi Liljenbäck, Päivi Poijärvi-Virta

Publikováno v: Bioconjugate Chemistry. 23(9):1981-1988

Esterified precursors of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA; 18) and 1,4,7-triazacyclononane-1,4,7-trisacetic acid (NOTA; 17,19) ligands bearing a dimethoxytritylated hydroxyl side arm were prepared and immobilized via an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f05ad96b46a5aa3edb6216231b1aac6
http://juuli.fi/Record/0248888912

68Ga-DOTA-Siglec-9:A new imaging tool to detect synovitis

Autor: Riikka Siitonen, Meeri Käkelä, Kimmo Jaakkola, Nina Savisto, Helena E. Virtanen, Sirpa Jalkanen, Heidi Liljenbäck, Petteri Lankinen, Jarmo Teuho, Tiina Saanijoki, Anu Autio, Jussi Mäkilä, Anne Roivainen

Publikováno v: Virtanen, H, Autio, A, Siitonen, R, Liljenbäck, H, Saanijoki, T, Lankinen, P, Mäkilä, J, Käkelä, M, Teuho, J, Savisto, N, Jaakkola, K, Jalkanen, S & Roivainen, A 2015, ' 68Ga-DOTA-Siglec-9 : A new imaging tool to detect synovitis ', Arthritis Research and Therapy, vol. 17, 308 . https://doi.org/10.1186/s13075-015-0826-8
Arthritis Research & Therapy

Introduction: Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon inflammation is rapidly translocated from intracellular sources to the endothelial cell surface. We have recently discovered that sialic acid- binding immunoglobuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6f4bbbdc6ab1ac0f90d49b40215173
https://cris.vtt.fi/en/publications/68dffe0f-3005-4e07-8685-0bef16194dd6

Neural Network Combustion Optimisation in Naantali Power Plant

Autor: Juha-Pekka Jalkanen, Jussi Mäkilä

Publikováno v: Artificial Neural Nets and Genetic Algorithms ISBN: 9783211836514

An optimisation system giving advice to the operators is installed to unit 2 of a coal-fired power plant located in the city of Naantali, Finland.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81db13a2ab00e6d62b6c29b858f2ab68
https://doi.org/10.1007/978-3-7091-6230-9_45