Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Jussi Kanto"'
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:91-95
Six healthy volunteers were given in an open study 15 mg of midazolam orally, and a couple of weeks later the same treatment preceded by 400 mg of cimetidine orally. We followed midazolam serum concentrations and the following pharmacodynamic paramet
Publikováno v:
Acta Pharmacologica et Toxicologica. 39:573-576
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:208-212
A simple, specific and sensitive radioimmunoassay is described for atropine (dl-hyoscyamine) and l-hyoscyamine. Antiserum was obtained from rabbits immunized with an immunogen prepared by coupling l-hyoscyamine to human serum albumin. By using 3H-atr
Publikováno v:
Acta Pharmacologica et Toxicologica. 39:477-480
The concentrations of digoxin in maternal and foetal serum and in foetal tissues were measured after two oral doses in 12–16 weeks pregnancies. In maternal serum a digoxin level of 1.3 ng/ml was found, while the foetal serum level was 0.7 ng/ml. Th
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:561-569
Methylergometrine concentrations in human and rabbit plasma were determined by a new radioimmunoassay after a single intravenous injection (0.2 mg in man and 0.05, 0.1 and 0.2 mg/kg in rabbits). Both in man and in the rabbit methylergometrine disappe
Publikováno v:
Acta Pharmacologica et Toxicologica. 41:489-496
The effects of two beta-adrenergic receptor blocking drugs, the non-selective propranolol and the beta1selective metoprolol, were studied on hemodynamics and plasma renin activity (PRA) of healthy volunteers in an ergometric exercise test. Oral doses
Publikováno v:
Acta Pharmacologica et Toxicologica. 36:33-38
Very significantly lower concentrations of diazepam at 15 minutes and 1 hour after 10 mg intravenous diazepam injection were found in chronic alcoholic patients in comparison to healthy controls. Compared to 13 healthy controls a more rapid eliminati
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:130-134
The concentrations of lorazepam and its conjugate were determined in maternal venous serum, in umbilical vein and artery serum, and in amniotic fluid after a single 2 mg intramuscular and 2.5 mg oral maternal administration. During normal delivery (2
Publikováno v:
Acta Pharmacologica et Toxicologica. 41:193-202
The passage of digoxin into the cerebrospinal fluid (CSF) was studied in 8 infants on maintenance therapy with digoxin, 11 adult patients on long-term digoxin therapy, and 15 patients, previously non-digitalized, who were given 0.5 mg digoxin orally
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:541-544