In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood

Autor: Mélanie C. Faure, Rita Khoueiry, Jusal Quanico, Hervé Acloque, Marie-Justine Guerquin, Michael J. Bertoldo, Claire Chevaleyre, Christelle Ramé, Isabelle Fournier, Michel Salzet, Joëlle Dupont, Pascal Froment

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance. Metformin is also used in the treatment of pregnancy disorders such as gestational diabetes. However, the consequences of foetal exposure

Externí odkaz: https://doaj.org/article/561fbbeda8784fa78b19930952249e77

Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer

Autor: Vivian Delcourt, Julien Franck, Eric Leblanc, Fabrice Narducci, Yves-Marie Robin, Jean-Pascal Gimeno, Jusal Quanico, Maxence Wisztorski, Firas Kobeissy, Jean-François Jacques, Xavier Roucou, Michel Salzet, Isabelle Fournier

Publikováno v: EBioMedicine, Vol 21, Iss C, Pp 55-64 (2017)

Background: Recently, it was demonstrated that proteins can be translated from alternative open reading frames (altORFs), increasing the size of the actual proteome. Top-down mass spectrometry-based proteomics allows the identification of intact prot

Externí odkaz: https://doaj.org/article/75a0a91739164e4aac8454c24b6e9f86

Improvement of biomolecular analysis in thin films using

Autor: Konstantin, Moshkunov, Benjamin, Tomasetti, Thomas, Daphnis, Vincent, Delmez, Kevin, Vanvarenberg, Véronique, Préat, Matthias, Lorenz, Jusal, Quanico, Geert, Baggerman, Filip, Lemiere, Christine, Dupont, Arnaud, Delcorte

Publikováno v: The Analyst. 146(21)

Sensitivity to molecular ions remains a limiting factor for high resolution imaging mass spectrometry of organic and biological materials. Here, we investigate a variant of matrix-enhanced secondary ion mass spectrometry in which the transfer of matr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5150239ad5c9ade2e1b1d1333f2bc6f1
https://pubmed.ncbi.nlm.nih.gov/34570146

On-Tissue Spatially-Resolved Glycoproteomics Guided by N-Glycan Imaging Reveal Global Dysregulation of Canine Glioma Glycoproteomic Landscape

Autor: Dominique Tierny, Soulaimane Aboulourad, Stacy A. Malaker, Antonella Raffo Romero, Carolyn R. Bertozzi, Firas Kobeissy, Jusal Quanico, Isabelle Fournier, Michel Salzet

Publikováno v: SSRN Electronic Journal.

We identify N-linked glycoproteins and deduce their spatial localization using spatially-resolved glycoproteomic guided by MALDI mass spectrometry N-glycan imaging on formalin-fixed paraffin embedded (FFPE) canine high-grade glioma tissues. The glyca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0541b943ae178636111df07e3f6c0012
https://doi.org/10.2139/ssrn.3723765

NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis

Autor: Jusal Quanico, Maxence Wisztorski, Eric Leblanc, Isabelle Fournier, Julien Franck, Michel Salzet, Tristan Cardon

Publikováno v: Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2017, 1865 (7), pp.891-900. ⟨10.1016/j.bbapap.2016.11.002⟩

International audience; Mass spectrometry (MS)-based microproteomics on localized regions of tissue sections was achieved by direct coupling of liquid microjunction microextraction with a nanoscale liquid chromatography-tandem MS, resulting in the id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57121922ffd9ef03c2685489c9c46bc
https://doi.org/10.1016/j.bbapap.2016.11.002